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Accurate identification of breast masses is crucial in diagnosing breast cancer; however, it can be challenging due to their small size and being camouflaged in surrounding normal glands. Worse still, it is also expensive in clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Xinyu Xiong , Churan Wang , Wenxue Li , Guanbin Li

Annotating cancerous regions in whole-slide images (WSIs) of pathology samples plays a critical role in clinical diagnosis, biomedical research, and machine learning algorithms development. However, generating exhaustive and accurate…

Computer Vision and Pattern Recognition · Computer Science 2022-06-09 Zhenzhen Wang , Carla Saoud , Sintawat Wangsiricharoen , Aaron W. James , Aleksander S. Popel , Jeremias Sulam

Segmentation of tumors in brain MRI images is a challenging task, where most recent methods demand large volumes of data with pixel-level annotations, which are generally costly to obtain. In contrast, image-level annotations, where only…

Image and Video Processing · Electrical Eng. & Systems 2019-11-07 Sergey Pavlov , Alexey Artemov , Maksim Sharaev , Alexander Bernstein , Evgeny Burnaev

Whole slide images (WSIs) pose unique challenges when training deep learning models. They are very large which makes it necessary to break each image down into smaller patches for analysis, image features have to be extracted at multiple…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Ozan Ciga , Tony Xu , Sharon Nofech-Mozes , Shawna Noy , Fang-I Lu , Anne L. Martel

The absence of adequately sufficient expert-level tumor annotations hinders the effectiveness of supervised learning based opportunistic cancer screening on medical imaging. Clinical reports (that are rich in descriptive textual details)…

Computer Vision and Pattern Recognition · Computer Science 2024-05-24 Guangyu Guo , Jiawen Yao , Yingda Xia , Tony C. W. Mok , Zhilin Zheng , Junwei Han , Le Lu , Dingwen Zhang , Jian Zhou , Ling Zhang

Pathologic analysis of surgical excision specimens for breast carcinoma is important to evaluate the completeness of surgical excision and has implications for future treatment. This analysis is performed manually by pathologists reviewing…

Image and Video Processing · Electrical Eng. & Systems 2021-01-22 David Joon Ho , Dig V. K. Yarlagadda , Timothy M. D'Alfonso , Matthew G. Hanna , Anne Grabenstetter , Peter Ntiamoah , Edi Brogi , Lee K. Tan , Thomas J. Fuchs

Deep learning has been widely used to analyze digitized hematoxylin and eosin (H&E)-stained histopathology whole slide images. Automated cancer segmentation using deep learning can be used to diagnose malignancy and to find novel…

Image and Video Processing · Electrical Eng. & Systems 2022-03-30 David Joon Ho , M. Herman Chui , Chad M. Vanderbilt , Jiwon Jung , Mark E. Robson , Chan-Sik Park , Jin Roh , Thomas J. Fuchs

Cancer is a complex disease that provides various types of information depending on the scale of observation. While most tumor diagnostics are performed by observing histopathological slides, radiology images should yield additional…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Marvin Lerousseau , Eric Deutsh , Nikos Paragios

Digitization of histopathology slides has led to several advances, from easy data sharing and collaborations to the development of digital diagnostic tools. Deep learning (DL) methods for classification and detection have shown great…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Apostolia Tsirikoglou , Karin Stacke , Gabriel Eilertsen , Martin Lindvall , Jonas Unger

Reliable classification of benign and malignant lesions in breast ultrasound images can provide an effective and relatively low cost method for early diagnosis of breast cancer. The accuracy of the diagnosis is however highly dependent on…

Image and Video Processing · Electrical Eng. & Systems 2021-02-24 Elham Yousef Kalaf , Ata Jodeiri , Seyed Kamaledin Setarehdan , Ng Wei Lin , Kartini Binti Rahman , Nur Aishah Taib , Sarinder Kaur Dhillon

Image segmentation is a fundamental problem in biomedical image analysis. Recent advances in deep learning have achieved promising results on many biomedical image segmentation benchmarks. However, due to large variations in biomedical…

Computer Vision and Pattern Recognition · Computer Science 2017-06-16 Lin Yang , Yizhe Zhang , Jianxu Chen , Siyuan Zhang , Danny Z. Chen

Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Pawel Mlynarski , Hervé Delingette , Antonio Criminisi , Nicholas Ayache

Accurate cancer diagnosis remains a critical challenge in digital pathology, largely due to the gigapixel size and complex spatial relationships present in whole slide images. Traditional multiple instance learning (MIL) methods often…

Computer Vision and Pattern Recognition · Computer Science 2024-04-18 Kechun Liu , Wenjun Wu , Joann G. Elmore , Linda G. Shapiro

For brain tumour segmentation, deep learning models can achieve human expert-level performance given a large amount of data and pixel-level annotations. However, the expensive exercise of obtaining pixel-level annotations for large amounts…

Computer Vision and Pattern Recognition · Computer Science 2023-10-11 Xiao Liu , Antanas Kascenas , Hannah Watson , Sotirios A. Tsaftaris , Alison Q. O'Neil

This paper deals with the multiple annotation problem in medical application of cancer detection in digital images. The main assumption is that though images are labeled by many experts, the number of images read by the same expert is not…

Computer Vision and Pattern Recognition · Computer Science 2014-12-10 Inna Stainvas , Alexandra Manevitch , Isaac Leichter

Breast cancer remains a global challenge, causing over 1 million deaths globally in 2018. To achieve earlier breast cancer detection, screening x-ray mammography is recommended by health organizations worldwide and has been estimated to…

Often in medical imaging, it is prohibitively challenging to produce enough boundary annotations to train deep neural networks for accurate tumor segmentation. We propose the use of weak labels about whether an image presents tumor or…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Eugene Vorontsov , Pavlo Molchanov , Christopher Beckham , Jan Kautz , Samuel Kadoury

Certain cancer types, notably pancreatic cancer, are difficult to detect at an early stage, motivating robust biomarker-based screening. Liquid biopsies enable non-invasive monitoring of circulating biomarkers, but typical machine learning…

Machine Learning · Computer Science 2025-11-21 Chongmin Lee , Jihie Kim

The fine-grained annotations in whole slide images (WSIs) show the boundaries of various pathological regions. However, generating such detailed annotation is often costly, whereas the coarse annotations are relatively simpler to produce.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Bingjian Yao , Weiping Lin , Yan He , Zheng Wang , Liangsheng Wang

The scarcity of labeled data is a major bottleneck for developing accurate and robust deep learning-based models for histopathology applications. The problem is notably prominent for the task of metastasis detection in lymph nodes, due to…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Apostolia Tsirikoglou , Karin Stacke , Gabriel Eilertsen , Jonas Unger