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Dynamic optimisation occurs in a variety of real-world problems. To tackle these problems, evolutionary algorithms have been extensively used due to their effectiveness and minimum design effort. However, for dynamic problems, extra…

Neural and Evolutionary Computing · Computer Science 2020-08-11 Maryam Hasani Shoreh , Renato Hermoza Aragonés , Frank Neumann

We introduce highly optimized tolerance (HOT), a mechanism that connects evolving structure and power laws in interconnected systems. HOT systems arise, e.g., in biology and engineering, where design and evolution create complex systems…

Condensed Matter · Physics 2009-10-31 J. M. Carlson , John Doyle

Biological systems perform complex multi-step processes in a reproducible way despite underlying stochasticity. The standard explanation is micromanagement by molecular machinery that recognizes and corrects specific errors. Here we study…

Populations and Evolution · Quantitative Biology 2026-05-14 Riccardo Ravasio , Kabir Husain , Constantine G. Evans , Rob Phillips , Marco Ribezzi-Crivellari , Jack W. Szostak , Arvind Murugan

The co-evolution of network topology and dynamics is studied in an evolutionary Boolean network model that is a simple model of gene regulatory network. We find that a critical state emerges spontaneously resulting from interplay between…

Statistical Mechanics · Physics 2007-05-23 Min Liu , Kevin E. Bassler

The search for universal laws that help establish a relationship between dynamics and computation is driven by recent expansionist initiatives in biologically inspired computing. A general setting to understand both such dynamics and…

Machine Learning · Computer Science 2020-09-17 G Manjunath

Error correction is essential for modern computing systems, enabling information to be processed accurately even in the presence of noise. Here, we demonstrate a new approach which exploits an error correcting phase that emerges in a system…

Molecular recognition, which is essential in processing information in biological systems, takes place in a crowded noisy biochemical environment and requires the recognition of a specific target within a background of various similar…

Biomolecules · Quantitative Biology 2010-07-27 Yonatan Savir , Tsvi Tlusty

The phenomena of stochasticity in biochemical processes have been intriguing life scientists for the past few decades. We now know that living cells take advantage of stochasticity in some cases and counteract stochastic effects in others.…

Quantitative Methods · Quantitative Biology 2011-06-09 Michal Komorowski , Jacek Miekisz , Michael P. H. Stumpf

The dynamics of an ensemble of bistable elements with global time-delayed coupling under the influence of noise is studied analytically and numerically. Depending on the noise level the system undergoes ordering transitions and demonstrates…

Statistical Mechanics · Physics 2009-11-10 D. Huber , L. S. Tsimring

Cooperation is a persistent behavioral pattern of entities pooling and sharing resources. Its ubiquity in nature poses a conundrum. Whenever two entities cooperate, one must willingly relinquish something of value to the other. Why is this…

Adaptation and Self-Organizing Systems · Physics 2022-05-24 Ole Peters , Alexander Adamou

We observe that multi-body interactions, unlike two-body interactions, can implement any unitary operation on an encoded system in such a way that the evolution is uninterrupted by noise that the encoding is designed to protect against.…

Quantum Physics · Physics 2015-06-11 Os Vy , Xiaoting Wang , Kurt Jacobs

The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the…

Molecular Networks · Quantitative Biology 2008-05-28 Stefan Braunewell , Stefan Bornholdt

Stochastic fluctuations of molecular abundances are a ubiquitous feature of cellular processes and lead to significant cell-to-cell variability. Recent theoretical work established lower bounds for stochastic fluctuations in cells for broad…

Molecular Networks · Quantitative Biology 2025-05-06 Brayden Kell , Andreas Hilfinger

We investigate the evolution of populations of random Boolean networks under selection for robustness of the dynamics with respect to the perturbation of the state of a node. The fitness landscape contains a huge plateau of maximum fitness…

Populations and Evolution · Quantitative Biology 2009-11-13 Tamara Mihaljev , Barbara Drossel

Noise is ubiquitous in quantum systems and is a major obstacle for the advancement of quantum information science. Noise-robust quantum control achieves high-fidelity operations by engineering the evolution path so that first-order noise…

Quantum Physics · Physics 2025-10-09 Junkai Zeng , Xiu-Hao Deng

Protein evolution underpins life, and understanding its behavior as a system is of great importance. However, our current models of protein evolution are arguably too simplistic to allow quantitative interpretation and prediction of…

Recently, computational modelling became a very important research tool that enables us to study problems that for decades evaded scientific analysis. Evolutionary systems are certainly examples of such problems: they are composed of many…

Populations and Evolution · Quantitative Biology 2009-07-04 Adam Lipowski , Dorota Lipowska

The processes and mechanisms underlying the origin and maintenance of biological diversity have long been of central importance in ecology and evolution. The competitive exclusion principle states that the number of coexisting species is…

Populations and Evolution · Quantitative Biology 2020-12-02 Michael Doebeli , Eduardo Cancino Jaque , Iaroslav Ispolatov

Positive feedback and cooperativity in the regulation of gene expression are generally considered to be necessary for obtaining bistable expression states. Recently, a novel mechanism of bistability termed emergent bistability has been…

Quantitative Methods · Quantitative Biology 2012-10-22 Sayantari Ghosh , Subhasis Banerjee , Indrani Bose

Microbial populations in the natural environment are likely to experience growth conditions very different from those of a typical laboratory xperiment. In particular, removal rates of biomass and substrate are unlikely to be balanced under…

Populations and Evolution · Quantitative Biology 2015-05-18 Bhavin S. Khatri , Andrew Free , Rosalind J. Allen