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Background & Aims: Hepatic steatosis is a major cause of chronic liver disease. 2D ultrasound is the most widely used non-invasive tool for screening and monitoring, but associated diagnoses are highly subjective. We developed a scalable…

Image and Video Processing · Electrical Eng. & Systems 2021-10-13 Bowen Li , Dar-In Tai , Ke Yan , Yi-Cheng Chen , Shiu-Feng Huang , Tse-Hwa Hsu , Wan-Ting Yu , Jing Xiao , Le Lu , Adam P. Harrison

We consider the linear discriminant analysis problem in the high-dimensional settings. In this work, we propose PANDA(PivotAl liNear Discriminant Analysis), a tuning-insensitive method in the sense that it requires very little effort to…

Statistics Theory · Mathematics 2023-09-19 Ethan X. Fang , Yajun Mei , Yuyang Shi , Qunzhi Xu , Tuo Zhao

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning…

Machine Learning · Computer Science 2018-12-05 Yilong Yang , Zhuyifan Ye , Yan Su , Qianqian Zhao , Xiaoshan Li , Defang Ouyang

The recent advancement of foundation models (FMs) has brought about a paradigm shift, revolutionizing various sectors worldwide. The popular optimizers used to train these models are stochastic gradient descent-based algorithms, which face…

Machine Learning · Computer Science 2026-01-06 Shenglong Zhou , Ouya Wang , Ziyan Luo , Yongxu Zhu , Geoffrey Ye Li

Motivation: The high dimensionality of genomic data calls for the development of specific classification methodologies, especially to prevent over-optimistic predictions. This challenge can be tackled by compression and variable selection,…

Methodology · Statistics 2021-04-10 G. Durif , L. Modolo , J. Michaelsson , J. E. Mold , S. Lambert-Lacroix , F. Picard

This paper proposes an improved linear discriminant analysis called spectrally-corrected and regularized LDA (SRLDA). This method integrates the design ideas of the sample spectrally-corrected covariance matrix and the regularized…

Machine Learning · Statistics 2024-03-11 Hua Li , Wenya Luo , Zhidong Bai , Huanchao Zhou , Zhangni Pu

Automatic segmentation of medical images with DL algorithms has proven to be highly successful. With most of these algorithms, inter-observer variation is an acknowledged problem, leading to sub-optimal results. This problem is even more…

Computer Vision and Pattern Recognition · Computer Science 2021-02-17 Anjali Balagopal , Howard Morgan , Michael Dohopoloski , Ramsey Timmerman , Jie Shan , Daniel F. Heitjan , Wei Liu , Dan Nguyen , Raquibul Hannan , Aurelie Garant , Neil Desai , Steve Jiang

With recent advancements in the development of artificial intelligence applications using theories and algorithms in machine learning, many accurate models can be created to train and predict on given datasets. With the realization of the…

Machine Learning · Computer Science 2024-03-29 Pei Xi , Lin

Automatic detection of leukemic B-lymphoblast cancer in microscopic images is very challenging due to the complicated nature of histopathological structures. To tackle this issue, an automatic and robust diagnostic system is required for…

Image and Video Processing · Electrical Eng. & Systems 2019-09-27 Sara Hosseinzadeh Kassani , Peyman Hosseinzadeh kassani , Michal J. Wesolowski , Kevin A. Schneider , Ralph Deters

For prostate cancer patients, the Gleason score is one of the most important prognostic factors, potentially determining treatment independent of the stage. However, Gleason scoring is based on subjective microscopic examination of tumor…

Due to cancer's complex nature and variable response to therapy, precision oncology informed by omics sequence analysis has become the current standard of care. However, the amount of data produced for each patients makes it difficult to…

Machine Learning · Computer Science 2023-10-30 Patrick J. Lawrence , Xia Ning

Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each…

Quantitative Methods · Quantitative Biology 2016-12-05 Stefan Bauer , Nicolas Carion , Peter Schüffler , Thomas Fuchs , Peter Wild , Joachim M. Buhmann

In this paper, we propose a deep probabilistic multi-view model that is composed of a linear multi-view layer based on probabilistic canonical correlation analysis (CCA) description in the latent space together with deep generative networks…

Machine Learning · Computer Science 2020-03-10 Mahdi Karami , Dale Schuurmans

Deep learning (DL) has recently drawn much attention in image analysis, natural language process, and high-dimensional medical data analysis. Under the causal direct acyclic graph (DAG) interpretation, the input variables without incoming…

Applications · Statistics 2022-03-22 Jong-Hyeon Jeong , Yichen Jia

Regularized linear discriminant analysis (RLDA) is a widely used tool for classification and dimensionality reduction, but its performance in high-dimensional scenarios is inconsistent. Existing theoretical analyses of RLDA often lack clear…

Machine Learning · Statistics 2025-07-23 Yonghan Zhang , Zhangni Pu , Lu Yan , Jiang Hu

The utilisation of Deep Learning (DL) is advancing into increasingly more sophisticated applications. While it shows great potential to provide transformational capabilities, DL also raises new challenges regarding its reliability in…

Machine Learning · Computer Science 2021-06-03 Xingyu Zhao , Wei Huang , Alec Banks , Victoria Cox , David Flynn , Sven Schewe , Xiaowei Huang

Despite a lack of theoretical understanding, deep neural networks have achieved unparalleled performance in a wide range of applications. On the other hand, shallow representation learning with component analysis is associated with rich…

Machine Learning · Computer Science 2018-03-20 Calvin Murdock , Ming-Fang Chang , Simon Lucey

In the internet era there has been an explosion in the amount of digital text information available, leading to difficulties of scale for traditional inference algorithms for topic models. Recent advances in stochastic variational inference…

Machine Learning · Computer Science 2013-05-14 James Foulds , Levi Boyles , Christopher Dubois , Padhraic Smyth , Max Welling

Functional linear discriminant analysis (FLDA) is a powerful tool that extends LDA-mediated multiclass classification and dimension reduction to univariate time-series functions. However, in the age of large multivariate and incomplete…

Machine Learning · Computer Science 2026-04-23 Rahul Bordoloi , Clémence Réda , Orell Trautmann , Saptarshi Bej , Olaf Wolkenhauer

In recent days, Deep Learning (DL) techniques have become an emerging transformation in the field of machine learning, artificial intelligence, computer vision, and so on. Subsequently, researchers and industries have been highly endorsed…

Image and Video Processing · Electrical Eng. & Systems 2023-11-21 P. Kalaiselvi , S. Anusuya
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