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Segmentation tasks in medical imaging are inherently ambiguous: the boundary of a target structure is oftentimes unclear due to image quality and biological factors. As such, predicted segmentations from deep learning algorithms are…

Image and Video Processing · Electrical Eng. & Systems 2019-11-18 Katharina Hoebel , Ken Chang , Jay Patel , Praveer Singh , Jayashree Kalpathy-Cramer

One of the common issues in clinical decision-making is the presence of uncertainty, which often arises due to ambiguity in radiology reports, which often reflect genuine diagnostic uncertainty or limitations of automated label extraction…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Antik Aich Roy , Ujjwal Bhattacharya

Safe artificial intelligence for perception tasks remains a major challenge, partly due to the lack of data with high-quality labels. Annotations themselves are subject to aleatoric and epistemic uncertainty, which is typically ignored…

Machine Learning · Computer Science 2026-02-05 Jonathan Klees , Tobias Riedlinger , Peter Stehr , Bennet Böddecker , Daniel Kondermann , Matthias Rottmann

Cephalometric tracing method is usually used in orthodontic diagnosis and treatment planning. In this paper, we propose a deep learning based framework to automatically detect anatomical landmarks in cephalometric X-ray images. We train the…

Image and Video Processing · Electrical Eng. & Systems 2020-09-30 Zhusi Zhong , Jie Li , Zhenxi Zhang , Zhicheng Jiao , Xinbo Gao

A population quantity of interest in statistical shape analysis is the location of landmarks, which are points that aid in reconstructing and representing shapes of objects. We provide an automated, model-based approach to inferring…

Applications · Statistics 2017-10-16 Justin Strait , Oksana Chkrebtii , Sebastian Kurtek

Markerless biomechanics increasingly relies on 3D skeletal keypoints extracted from video, yet downstream biomechanical mappings typically treat these estimates as deterministic, providing no principled mechanism for frame-wise quality…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Cesare Davide Pace , Alessandro Marco De Nunzio , Claudio De Stefano , Francesco Fontanella , Mario Molinara

Landmark detection is a critical component of the image processing pipeline for automated aortic size measurements. Given that the thoracic aorta has a relatively conserved topology across the population and that a human annotator with…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Zhangxing Bian , Jiayang Zhong , Yanglong Lu , Charles R. Hatt , Nicholas S. Burris

The accurate estimation of predictive uncertainty carries importance in medical scenarios such as lung node segmentation. Unfortunately, most existing works on predictive uncertainty do not return calibrated uncertainty estimates, which…

Machine Learning · Computer Science 2022-05-31 Shi Hu , Daniel Worrall , Stefan Knegt , Bas Veeling , Henkjan Huisman , Max Welling

Segmentation of curvilinear structures such as vasculature and road networks is challenging due to relatively weak signals and complex geometry/topology. To facilitate and accelerate large scale annotation, one has to adopt semi-automatic…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Saumya Gupta , Yikai Zhang , Xiaoling Hu , Prateek Prasanna , Chao Chen

Reliable uncertainty quantification is crucial for trustworthy decision-making and the deployment of AI models in medical imaging. While prior work has explored the ability of neural networks to quantify predictive, epistemic, and aleatoric…

Machine Learning · Statistics 2025-08-07 Simon Baur , Wojciech Samek , Jackie Ma

Echocardiography plays a fundamental role in the extraction of important clinical parameters (e.g. left ventricular volume and ejection fraction) required to determine the presence and severity of heart-related conditions. When deploying…

Computer Vision and Pattern Recognition · Computer Science 2025-02-19 Thierry Judge , Olivier Bernard , Woo-Jin Cho Kim , Alberto Gomez , Arian Beqiri , Agisilaos Chartsias , Pierre-Marc Jodoin

In this paper we describe a probabilistic method for estimating the position of an object along with its covariance matrix using neural networks. Our method is designed to be robust to outliers, have bounded gradients with respect to the…

Computer Vision and Pattern Recognition · Computer Science 2021-11-22 David Mohlin , Gerald Bianchi , Josephine Sullivan

Modern face alignment methods have become quite accurate at predicting the locations of facial landmarks, but they do not typically estimate the uncertainty of their predicted locations nor predict whether landmarks are visible. In this…

Computer Vision and Pattern Recognition · Computer Science 2020-04-08 Abhinav Kumar , Tim K. Marks , Wenxuan Mou , Ye Wang , Michael Jones , Anoop Cherian , Toshiaki Koike-Akino , Xiaoming Liu , Chen Feng

The accurate localization of facial landmarks is at the core of face analysis tasks, such as face recognition and facial expression analysis, to name a few. In this work, we propose a novel localization approach based on a deep learning…

Computer Vision and Pattern Recognition · Computer Science 2021-07-21 Shahar Mahpod , Rig Das , Emanuele Maiorana , Yosi Keller , Patrizio Campisi

Automated detection of anatomical landmarks plays a crucial role in many diagnostic and surgical applications. Progresses in deep learning (DL) methods have resulted in significant performance enhancement in tasks related to anatomical…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Soorena Salari , Hassan Rivaz , Yiming Xiao

Accurate image registration is essential in many medical imaging applications, yet most deep registration networks provide little indication of when or where their predictions are unreliable. Existing uncertainty estimation approaches, such…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Lin Tian , Xiaoling Hu , Juan Eugenio Iglesias

Surface normal estimation from a single image is an important task in 3D scene understanding. In this paper, we address two limitations shared by the existing methods: the inability to estimate the aleatoric uncertainty and lack of detail…

Computer Vision and Pattern Recognition · Computer Science 2021-09-22 Gwangbin Bae , Ignas Budvytis , Roberto Cipolla

Radiologists possess diverse training and clinical experiences, leading to variations in the segmentation annotations of lung nodules and resulting in segmentation uncertainty.Conventional methods typically select a single annotation as the…

Image and Video Processing · Electrical Eng. & Systems 2023-09-12 Han Yang , Qiuli Wang , Yue Zhang , Zhulin An , Chen Liu , Xiaohong Zhang , S. Kevin Zhou

With the increasing availability of new image registration approaches, an unbiased evaluation is becoming more needed so that clinicians can choose the most suitable approaches for their applications. Current evaluations typically use…

Computer Vision and Pattern Recognition · Computer Science 2020-03-24 Jie Luo , Guangshen Ma , Sarah Frisken , Parikshit Juvekar , Nazim Haouchine , Zhe Xu , Yiming Xiao , Alexandra Golby , Patrick Codd , Masashi Sugiyama , William Wells

We study a challenging problem of unsupervised discovery of object landmarks. Many recent methods rely on bottlenecks to generate 2D Gaussian heatmaps however, these are limited in generating informed heatmaps while training, presumably due…

Computer Vision and Pattern Recognition · Computer Science 2023-09-20 Mamona Awan , Muhammad Haris Khan , Sanoojan Baliah , Muhammad Ahmad Waseem , Salman Khan , Fahad Shahbaz Khan , Arif Mahmood