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Neural networks have recently been established as a viable classification method for imaging mass spectrometry data for tumor typing. For multi-laboratory scenarios however, certain confounding factors may strongly impede their performance.…

Non-mass enhancing lesions (NME) constitute a diagnostic challenge in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of the breast. Computer Aided Diagnosis (CAD) systems provide physicians with advanced tools for analysis,…

Image and Video Processing · Electrical Eng. & Systems 2018-09-27 Ignacio Alvarez Illan , Javier Ramirez , Juan M. Gorriz , Maria Adele Marino , Daly Avendaño , Thomas Helbich , Pascal Baltzer , Katja Pinker , Anke Meyer-Baese

Background: Pancreatic cancer is one of the most aggressive cancers, with poor survival rates. Endoscopic ultrasound (EUS) is a key diagnostic modality, but its effectiveness is constrained by operator subjectivity. This study evaluates a…

Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional…

Computer Vision and Pattern Recognition · Computer Science 2023-06-07 Liisa Petäinen , Juha P. Väyrynen , Pekka Ruusuvuori , Ilkka Pölönen , Sami Äyrämö , Teijo Kuopio

Deep learning is expected to aid pathologists by automating tasks such as tumour segmentation. We aimed to develop one universal tumour segmentation model for histopathological images and examine its performance in different cancer types.…

Imaging in clinical oncology trials provides a wealth of information that contributes to the drug development process, especially in early phase studies. This paper focuses on kinetic modeling in DCE-MRI, inspired by mixed-effects models…

Applications · Statistics 2020-04-22 Volker J. Schmid , Brandon Whitcher , Anwar R. Padhani , N. Jane Taylor , Guang-Zhong Yang

The superior soft tissue differentiation provided by MRI may enable more accurate tumor segmentation compared to CT and PET, potentially enhancing adaptive radiotherapy treatment planning. The Head and Neck Tumor Segmentation for MR-Guided…

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

There exists unexplained diverse variation within the predefined colon cancer stages using only features either from genomics or histopathological whole slide images as prognostic factors. Unraveling this variation will bring about improved…

Quantitative Methods · Quantitative Biology 2022-12-15 Olalekan Ogundipe , Zeyneb Kurt , Wai Lok Woo

In this paper, we describe a dataset relating to cellular and physical conditions of patients who are operated upon to remove colorectal tumours. This data provides a unique insight into immunological status at the point of tumour removal,…

Machine Learning · Computer Science 2013-07-08 Chris Roadknight , Uwe Aickelin , Alex Ladas , Daniele Soria , John Scholefield , Lindy Durrant

Automated brain tumour segmentation has the potential of making a massive improvement in disease diagnosis, surgery, monitoring and surveillance. However, this task is extremely challenging. Here, we describe our automated segmentation…

Image and Video Processing · Electrical Eng. & Systems 2020-05-13 Indrajit Mazumdar

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays an important role in breast cancer screening, tumor assessment, and treatment planning and monitoring. The dynamic changes in contrast in different tissues help to…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Rui Wang , Yuexi Du , John Lewin , R. Todd Constable , Nicha C. Dvornek

Accurate classification of brain tumors from magnetic resonance imaging (MRI) plays a critical role in early diagnosis and effective treatment planning. In this study, we propose a deep learning framework based on Vision Transformers (ViT)…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Faisal Ahmed

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for breast cancer diagnosis due to its ability to characterize tissue through contrast agent kinetics. However, traditional DCE-MRI protocols require multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Ruben D. Fonnegra , Maria Liliana Hernández , Juan C. Caicedo , Gloria M. Díaz

The Dice score is widely used for binary segmentation due to its robustness to class imbalance. Soft generalisations of the Dice score allow it to be used as a loss function for training convolutional neural networks (CNN). Although CNNs…

Computer Vision and Pattern Recognition · Computer Science 2018-02-27 Lucas Fidon , Wenqi Li , Luis C. Garcia-Peraza-Herrera , Jinendra Ekanayake , Neil Kitchen , Sebastien Ourselin , Tom Vercauteren

Objective: To develop an automatic image normalization algorithm for intensity correction of images from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) acquired by different MRI scanners with various imaging…

Computer Vision and Pattern Recognition · Computer Science 2018-07-09 Jun Zhang , Ashirbani Saha , Brian J. Soher , Maciej A. Mazurowski

With a high rate of morbidity and mortality, colorectal cancer (CRC) ranks third in mortality among cancers. By analyzing the texture properties of images and quantifying the heterogeneity of tumors, radiomics and radiogenomics are…

Medical Physics · Physics 2024-06-25 Parsa Karami , Reza Elahi

Background. A large number of algorithms is being developed to reconstruct evolutionary models of individual tumours from genome sequencing data. Most methods can analyze multiple samples collected either through bulk multi-region…

Genomics · Quantitative Biology 2019-03-26 Daniele Ramazzotti , Alex Graudenzi , Luca De Sano , Marco Antoniotti , Giulio Caravagna

Cancer is one of the leading causes of death worldwide, and head and neck (H&N) cancer is amongst the most prevalent types. Positron emission tomography and computed tomography are used to detect, segment and quantify the tumor region.…

Image and Video Processing · Electrical Eng. & Systems 2022-05-13 Ikboljon Sobirov , Otabek Nazarov , Hussain Alasmawi , Mohammad Yaqub