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Medical images are generally labeled by multiple experts before the final ground-truth labels are determined. Consensus or disagreement among experts regarding individual images reflects the gradeability and difficulty levels of the image.…
Purpose: To evaluate nerve fiber layer (NFL) reflectance for glaucoma diagnosis. Methods: Participants were imaged with 4.5X4.5-mm volumetric disc scans using spectral-domain optical coherence tomography (OCT). The normalized NFL…
The ratio of the average tangential shear signal of different weak lensing source populations around the same lens galaxies, also known as a shear ratio, provides an important test of lensing systematics and a potential source of…
We introduce a new methodology 'charcoal' for estimating the location of sparse changes in high-dimensional linear regression coefficients, without assuming that those coefficients are individually sparse. The procedure works by…
Anomaly detection and localization in medical imaging remain critical challenges in healthcare. This paper introduces Spatial-MSMA (Multiscale Score Matching Analysis), a novel unsupervised method for anomaly localization in volumetric…
Inspired by foveal vision, hard attention models promise interpretability and parameter economy. However, existing models like the Recurrent Model of Visual Attention (RAM) and Deep Recurrent Attention Model (DRAM) failed to model the…
Glaucoma is the leading cause of preventable, irreversible blindness world-wide. The disease can remain asymptomatic until severe, and an estimated 50%-90% of people with glaucoma remain undiagnosed. Glaucoma screening is recommended for…
Demographic studies of cosmic populations must contend with measurement errors and selection effects. We survey some of the key ideas astronomers have developed to deal with these complications, in the context of galaxy surveys and the…
One of the important parameters for the assessment of glaucoma is optic nerve head (ONH) evaluation, which usually involves depth estimation and subsequent optic disc and cup boundary extraction. Depth is usually obtained explicitly from…
Astronomical instruments generally possess spatially variant point-spread functions, which determine the amount by which an image pixel is blurred as a function of position. Several techniques have been devised to handle this variability in…
Purpose: The optic nerve head (ONH) undergoes complex and deep 3D morphological changes during the development and progression of glaucoma. Optical coherence tomography (OCT) is the current gold standard to visualize and quantify these…
Latent space models (LSMs) are often used to analyze dynamic (time-varying) networks that evolve in continuous time. Existing approaches to Bayesian inference for these models rely on Markov chain Monte Carlo algorithms, which cannot handle…
Statistical shape modeling (SSM) directly from 3D medical images is an underutilized tool for detecting pathology, diagnosing disease, and conducting population-level morphology analysis. Deep learning frameworks have increased the…
Tear film rupture on the corneal surface plays a critical role in ocular health and visual comfort. Conventional theoretical approaches often idealize the cornea as a perfectly smooth surface, ignoring the surface roughness that are…
Discriminating between Parkinson's Disease (PD) and Progressive Supranuclear Palsy (PSP) is difficult due to overlapping symptoms, especially early on. Saccades (rapid conjugate eye movements between fixation points) are affected by both…
In this paper we propose a novel method for the segmentation of longitudinal brain MRI scans of patients suffering from Multiple Sclerosis. The method builds upon an existing cross-sectional method for simultaneous whole-brain and lesion…
Childhood myopia constitutes a significant global health concern. It exhibits an escalating prevalence and has the potential to evolve into severe, irreversible conditions that detrimentally impact familial well-being and create substantial…
Several methods have been proposed in the spatial statistics literature for the analysis of big data sets in continuous domains. However, new methods for analyzing high-dimensional areal data are still scarce. Here, we propose a scalable…
Stroke is a major public health problem, affecting millions worldwide. Deep learning has recently demonstrated promise for enhancing the diagnosis and risk prediction of stroke. However, existing methods rely on costly medical imaging…
It is important to characterize the temporal trajectories of disease-related biomarkers in order to monitor progression and identify potential points of intervention. This is especially important for neurodegenerative diseases, as…