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The advent of large scale, high-throughput genomic screening has introduced a wide range of tests for diagnostic purposes. Prominent among them are tests using miRNA expression levels. Genomics and proteomics now provide expression levels…

Genomics · Quantitative Biology 2016-11-08 Neerja Garikipati

Optimization plays a central role in modern radiation therapy, where it is used to determine optimal treatment machine parameters in order to deliver precise doses adapted to each patient case. In general, solving the optimization problems…

Optimization and Control · Mathematics 2024-05-07 Felix Liu , Albin Fredriksson , Stefano Markidis

Computational pathology is part of precision oncology medicine. The integration of high-throughput data including genomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics into clinical practice improves cancer treatment…

Image and Video Processing · Electrical Eng. & Systems 2022-06-07 Liangrui Pan , Zhichao Feng , Shaoliang Peng

Purpose: Radio-frequency ablations play an important role in the therapy of malignant liver lesions. The navigation of a needle to the lesion poses a challenge for both the trainees and intervening physicians. Methods: This publication…

Medical Physics · Physics 2019-07-18 Niclas Kath , Heinz Handels , Andre Mastmeyer

External beam X-ray therapy (XRT) and proton therapy (PT) are effective and widely accepted forms of treatment for many types of cancer. However, the procedures require extensive computerized planning. Current planning systems for both XRT…

Graphics · Computer Science 2018-11-30 Felix G. Hamza-Lup , Shane Farrar , Erik Leon

Radiation Treatment Planning (RTP) is the process of planning the appropriate external beam radiotherapy to combat cancer in human patients. RTP is a complex and compute-intensive task, which often takes a long time (several hours) to…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-21 Felix Liu , Niclas Jansson , Artur Podobas , Albin Fredriksson , Stefano Markidis

In the realm of medical science, the pursuit of enhancing treatment efficacy and patient outcomes continues to drive innovation. This study delves into the integration of biomimicry principles within the domain of Radiation Therapy (RT) to…

Neural and Evolutionary Computing · Computer Science 2025-01-07 Keshav Kumar K. , NVSL Narasimham

The Random Phase Approximation (RPA) for correlation energy in the grid-based projector augmented wave (gpaw) code is accelerated by porting to the Graphics Processing Unit (GPU) architecture. The acceleration is achieved by grouping…

Computational Physics · Physics 2013-07-31 Jun Yan , Lin Li , Christopher O'Grady

Advance in medical imaging is an important part in deep learning research. One of the goals of computer vision is development of a holistic, comprehensive model which can identify tumors from histology slides obtained via biopsies. A major…

Image and Video Processing · Electrical Eng. & Systems 2024-12-18 Vidit Gautam

Radiation therapy is an effective and widely accepted form of treatment for many types of cancer that requires extensive computerized planning. Unfortunately, current treatment planning systems have limited or no visual aid that combines…

Graphics · Computer Science 2018-11-30 Felix G. Hamza-Lup , Ivan Sopin , Omar Zeidan

Gene expression can be used to subtype breast cancer with improved prediction of risk of recurrence and treatment responsiveness over that obtained using routine immunohistochemistry (IHC). However, in the clinic, molecular profiling is…

Computer Vision and Pattern Recognition · Computer Science 2023-05-09 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H Graham , Lois Browne , Arcot Sowmya , Erik Meijering

Recent advances in using quantitative ultrasound (QUS) methods have provided a promising framework to non-invasively and inexpensively monitor or predict the effectiveness of therapeutic cancer responses. One of the earliest steps in using…

Computer Vision and Pattern Recognition · Computer Science 2017-01-16 Mehrdad J. Gangeh , Hamid R. Tizhoosh , Kan Wu , Dun Huang , Hadi Tadayyon , Gregory J. Czarnota

Explainable AI (XAI) in medical histopathology is essential for enhancing the interpretability and clinical trustworthiness of deep learning models in cancer diagnosis. However, the black-box nature of these models often limits their…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H. Graham , Lois Browne , Arcot Sowmya , Erik Meijering

In this paper we describe and demonstrate a C++ code written to determine the trajectory of particles traversing oriented single crystals and a CUDA code written to evaluate the radiation spectra from charged particles with arbitrary…

Computational Physics · Physics 2019-10-24 Christian Flohr Nielsen

Objective: Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires the iterative adjustment of model parameters to balance multiple conflicting objectives. Recent advancements in frontier…

Background and Objective: Non-invasively predicting the risk of cancer metastasis before surgery plays an essential role in determining optimal treatment methods for cancer patients (including who can benefit from neoadjuvant chemotherapy).…

Surgical tumor resection aims to remove all cancer cells in the tumor margin and at centimeter-scale depths below the tissue surface. During surgery, microscopic clusters of disease are intraoperatively difficult to visualize and are often…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Rahul Lall , Youngho Seo , Ali M. Niknejad , Mekhail Anwar

Accurate differentiation of brain tumor types on magnetic resonance imaging (MRI) is critical for guiding treatment planning in neuro-oncology. Recent advances in large language models (LLMs) have enabled visual question answering (VQA)…

Computer Vision and Pattern Recognition · Computer Science 2025-08-15 Mojtaba Safari , Shansong Wang , Mingzhe Hu , Zach Eidex , Qiang Li , Xiaofeng Yang

Proton therapy is a cancer treatment technique currently in growth worldwide. It offers advantages with respect to conventional X-ray and $\gamma$-ray radiotherapy, in particular, a better control of the dose deposition allowing to reach a…

This study deliberates on the application of advanced AI techniques for brain tumor classification through MRI, wherein the training includes the present best deep learning models to enhance diagnosis accuracy and the potential of usability…