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Iterative Learning Control (ILC) schemes can guarantee properties such as asymptotic stability and monotonic error convergence, but do not, in general, ensure adherence to output constraints. The topic of this paper is the design of a…

Systems and Control · Electrical Eng. & Systems 2021-08-12 Michael Meindl , Fabio Molinari , Jörg Raisch , Thomas Seel

The rapid progress in generative models has resulted in impressive leaps in generation quality, blurring the lines between synthetic and real data. Web-scale datasets are now prone to the inevitable contamination by synthetic data, directly…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Damien Ferbach , Quentin Bertrand , Avishek Joey Bose , Gauthier Gidel

We explore the methodology and theory of reward-directed generation via conditional diffusion models. Directed generation aims to generate samples with desired properties as measured by a reward function, which has broad applications in…

Machine Learning · Computer Science 2023-07-17 Hui Yuan , Kaixuan Huang , Chengzhuo Ni , Minshuo Chen , Mengdi Wang

Generative models lack rigorous statistical guarantees for their outputs and are therefore unreliable in safety-critical applications. In this work, we propose Sequential Conformal Prediction for Generative Models (SCOPE-Gen), a sequential…

Machine Learning · Computer Science 2025-02-18 Klaus-Rudolf Kladny , Bernhard Schölkopf , Michael Muehlebach

Prior work on controllable text generation usually assumes that the controlled attribute can take on one of a small set of values known a priori. In this work, we propose a novel task, where the syntax of a generated sentence is controlled…

Computation and Language · Computer Science 2019-06-04 Mingda Chen , Qingming Tang , Sam Wiseman , Kevin Gimpel

Clinical trials face mounting challenges: fragmented patient populations, slow enrollment, and unsustainable costs, particularly for late phase trials in oncology and rare diseases. While external control arms built from real-world data…

Machine Learning · Computer Science 2025-11-21 Perrine Chassat , Van Tuan Nguyen , Lucas Ducrot , Emilie Lanoy , Agathe Guilloux

Directed evolution is an iterative laboratory process of designing proteins with improved function by iteratively synthesizing new protein variants and evaluating their desired property with expensive and time-consuming biochemical…

Machine Learning · Computer Science 2025-09-08 Matouš Soldát , Jiří Kléma

Conditional generation models for longitudinal sequences can produce new or modified trajectories given a conditioning input. However, they often lack control over when the condition should take effect (timing) and which variables it should…

Machine Learning · Computer Science 2026-03-10 Michelle M. Li , Kevin Li , Yasha Ektefaie , Ying Jin , Yepeng Huang , Shvat Messica , Tianxi Cai , Marinka Zitnik

Recent generative adversarial networks (GANs) are able to generate impressive photo-realistic images. However, controllable generation with GANs remains a challenging research problem. Achieving controllable generation requires semantically…

Machine Learning · Computer Science 2021-05-04 Grigorios G Chrysos , Jean Kossaifi , Zhiding Yu , Anima Anandkumar

We propose an alternative generator architecture for generative adversarial networks, borrowing from style transfer literature. The new architecture leads to an automatically learned, unsupervised separation of high-level attributes (e.g.,…

Neural and Evolutionary Computing · Computer Science 2019-04-01 Tero Karras , Samuli Laine , Timo Aila

To solve Math Word Problems, human students leverage diverse reasoning logic that reaches different possible equation solutions. However, the mainstream sequence-to-sequence approach of automatic solvers aims to decode a fixed solution…

Computation and Language · Computer Science 2022-12-01 Yibin Shen , Qianying Liu , Zhuoyuan Mao , Zhen Wan , Fei Cheng , Sadao Kurohashi

The in silico design of peptides and proteins as binders is useful for diagnosis and therapeutics due to their low adverse effects and major specificity. To select the most promising candidates, a key matter is to understand their…

Biomolecules · Quantitative Biology 2021-02-03 Rodrigo Ochoa , Miguel A. Soler , Alessandro Laio , Pilar Cossio

Training supervised deep neural networks that perform defect detection and segmentation requires large-scale fully-annotated datasets, which can be hard or even impossible to obtain in industrial environments. Generative AI offers…

Computer Vision and Pattern Recognition · Computer Science 2024-01-09 Gabriele Valvano , Antonino Agostino , Giovanni De Magistris , Antonino Graziano , Giacomo Veneri

Large language models often struggle with length generalization and solving complex problem instances beyond their training distribution. We present a self-improvement approach where models iteratively generate and learn from their own…

Machine Learning · Computer Science 2025-02-14 Nayoung Lee , Ziyang Cai , Avi Schwarzschild , Kangwook Lee , Dimitris Papailiopoulos

Several image pattern recognition tasks rely on superpixel generation as a fundamental step. Image analysis based on superpixels facilitates domain-specific applications, also speeding up the overall processing time of the task. Recent…

Computer Vision and Pattern Recognition · Computer Science 2018-02-19 Marcelo Santos , Luciano Oliveira

In this paper, we investigate a novel artificial intelligence generation task termed Generated Contents Enrichment (GCE). Conventional AI content generation produces visually realistic content by implicitly enriching the given textual…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Mahdi Naseri , Jiayan Qiu , Zhou Wang

This paper presents an intracellular feedback control strategy, to regulate the gene expression process dynamics. For this purpose, two types of genetic circuits are designed in order to compare concentrations of the input transcription…

Systems and Control · Computer Science 2016-06-15 Jafar Kazemi , Sadjad Ozgoli

Distributional regression aims to estimate the full conditional distribution of a target variable, given covariates. Popular methods include linear and tree-ensemble based quantile regression. We propose a neural network-based…

Methodology · Statistics 2024-07-08 Xinwei Shen , Nicolai Meinshausen

We consider controllable DNA sequence design, where sequences are generated by conditioning on specific biological properties. While language models (LMs) such as GPT and BERT have achieved remarkable success in natural language generation,…

Machine Learning · Computer Science 2025-12-10 Xingyu Su , Xiner Li , Yuchao Lin , Ziqian Xie , Degui Zhi , Shuiwang Ji

Conditional discrete generative models struggle to faithfully compose multiple input conditions. To address this, we derive a theoretically-grounded formulation for composing discrete probabilistic generative processes, with masked…

Machine Learning · Computer Science 2026-04-08 Jamie Stirling , Noura Al-Moubayed , Chris G. Willcocks , Hubert P. H. Shum