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In this paper, we study the generative models of sequential discrete data. To tackle the exposure bias problem inherent in maximum likelihood estimation (MLE), generative adversarial networks (GANs) are introduced to penalize the…

Machine Learning · Computer Science 2019-05-14 Sidi Lu , Lantao Yu , Siyuan Feng , Yaoming Zhu , Weinan Zhang , Yong Yu

We consider the problem of modeling the effects of perturbations like gene knockouts on measurements such as single-cell RNA counts. Given data for some perturbations, we aim to predict the distribution of measurements for new combinations…

Directed evolution is a molecular biology technique that is transforming protein engineering by creating proteins with desirable properties and functions. However, it is experimentally impossible to perform the deep mutational scanning of…

Biomolecules · Quantitative Biology 2023-06-09 Yuchi Qiu , Guo-Wei Wei

Deep sequence models have achieved notable success in time-series analysis, such as interpolation and forecasting. Recent advances move beyond discrete-time architectures like Recurrent Neural Networks (RNNs) toward continuous-time…

Machine Learning · Computer Science 2025-08-05 Haoran Li , Muhao Guo , Yang Weng , Hanghang Tong

The simplest way to obtain continuous interpolation between two points in high dimensional space is to draw a line between them. While previous works focused on the general connectivity between model parameters, we explored linear…

Computation and Language · Computer Science 2022-11-23 Mark Rofin , Nikita Balagansky , Daniil Gavrilov

Counterfactual explanations (CEs) are a practical tool for demonstrating why machine learning classifiers make particular decisions. For CEs to be useful, it is important that they are easy for users to interpret. Existing methods for…

Machine Learning · Computer Science 2021-03-17 Lisa Schut , Oscar Key , Rory McGrath , Luca Costabello , Bogdan Sacaleanu , Medb Corcoran , Yarin Gal

Instances generation is crucial for linear programming algorithms, which is necessary either to find the optimal pivot rules by training learning method or to evaluate and verify corresponding algorithms. This study proposes a general…

Optimization and Control · Mathematics 2022-11-22 Anqi Li , Congying Han , Tiande Guo

The premise of identifiable and causal representation learning is to improve the current representation learning paradigm in terms of generalizability or robustness. Despite recent progress in questions of identifiability, more theoretical…

Machine Learning · Computer Science 2024-03-06 Sorawit Saengkyongam , Elan Rosenfeld , Pradeep Ravikumar , Niklas Pfister , Jonas Peters

\noindent Hyper-parameter selection is a central practical problem in modern machine learning, governing regularization strength, model capacity, and robustness choices. Cross-validation is often computationally prohibitive at scale, while…

Machine Learning · Statistics 2025-12-24 Hedibert Lopes , Nick Polson , Vadim Sokolov

Gene expression analysis aims at identifying the genes able to accurately predict biological parameters like, for example, disease subtyping or progression. While accurate prediction can be achieved by means of many different techniques,…

Methodology · Statistics 2008-09-11 Christine De Mol , Sofia Mosci , Magali Traskine , Alessandro Verri

Iterative feature space optimization involves systematically evaluating and adjusting the feature space to improve downstream task performance. However, existing works suffer from three key limitations:1) overlooking differences among data…

Machine Learning · Computer Science 2026-05-26 Yanping Wu , Yanyong Huang , Zhengzhang Chen , Zijun Yao , Yanjie Fu , Kunpeng Liu , Xiao Luo , Dongjie Wang

A well-trained Convolutional Neural Network can easily be pruned without significant loss of performance. This is because of unnecessary overlap in the features captured by the network's filters. Innovations in network architecture such as…

Computer Vision and Pattern Recognition · Computer Science 2019-02-26 Aaditya Prakash , James Storer , Dinei Florencio , Cha Zhang

Generative models that satisfy hard constraints are critical in many scientific and engineering applications, where physical laws or system requirements must be strictly respected. Many existing constrained generative models, especially…

Machine Learning · Computer Science 2025-03-05 Chaoran Cheng , Boran Han , Danielle C. Maddix , Abdul Fatir Ansari , Andrew Stuart , Michael W. Mahoney , Yuyang Wang

Recent advancements in cognitive computing, with the integration of deep learning techniques, have facilitated the development of intelligent cognitive systems (ICS). This is particularly beneficial in the context of rail defect detection,…

Computer Vision and Pattern Recognition · Computer Science 2024-01-02 Rahatara Ferdousi , Chunsheng Yang , M. Anwar Hossain , Fedwa Laamarti , M. Shamim Hossain , Abdulmotaleb El Saddik

Generative Adversarial Networks (GANs) have seen steep ascension to the peak of ML research zeitgeist in recent years. Mostly catalyzed by its success in the domain of image generation, the technique has seen wide range of adoption in a…

Machine Learning · Statistics 2018-05-09 Aparna Balagopalan , Satya Gorti , Mathieu Ravaut , Raeid Saqur

Discrete audio tokens derived from self-supervised learning models have gained widespread usage in speech generation. However, current practice of directly utilizing audio tokens poses challenges for sequence modeling due to the length of…

Sound · Computer Science 2024-01-17 Feiyu Shen , Yiwei Guo , Chenpeng Du , Xie Chen , Kai Yu

A deep generative model such as a GAN learns to model a rich set of semantic and physical rules about the target distribution, but up to now, it has been obscure how such rules are encoded in the network, or how a rule could be changed. In…

Computer Vision and Pattern Recognition · Computer Science 2020-07-31 David Bau , Steven Liu , Tongzhou Wang , Jun-Yan Zhu , Antonio Torralba

Speech-to-text (S2T) generation systems frequently face challenges in low-resource scenarios, primarily due to the lack of extensive labeled datasets. One emerging solution is constructing virtual training samples by interpolating inputs…

Computation and Language · Computer Science 2024-06-25 Chen Xu , Jie Wang , Xiaoqian Liu , Qianqian Dong , Chunliang Zhang , Tong Xiao , Jingbo Zhu , Dapeng Man , Wu Yang

We study unsupervised learning by developing introspective generative modeling (IGM) that attains a generator using progressively learned deep convolutional neural networks. The generator is itself a discriminator, capable of introspection:…

Computer Vision and Pattern Recognition · Computer Science 2017-04-26 Justin Lazarow , Long Jin , Zhuowen Tu

Class-incremental learning (CIL) is a particularly challenging variant of continual learning, where the goal is to learn to discriminate between all classes presented in an incremental fashion. Existing approaches often suffer from…

Machine Learning · Computer Science 2024-03-12 Michał Zając , Tinne Tuytelaars , Gido M. van de Ven
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