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Recently, it has been shown that the transition rates of the illness-death model (IDM) for chronic conditions are related to the percentages of people in the states by a three-dimensional system of differential equations [Bri24]. The aim of…

Applications · Statistics 2025-02-05 Ralph Brinks

This paper descibes a new method for deriving incidence rates of a chronic disease from prevalence data. It is based on a new ordinary differential equation, which relates the change in the age-specific prevalence to the agespecific…

Quantitative Methods · Quantitative Biology 2011-12-14 Ralph Brinks

We use the illness-death model (IDM) for chronic conditions to derive a new analytical relation between the transition rates between the states of the IDM. The transition rates are the incidence rate (i) and the mortality rates of people…

Methodology · Statistics 2024-02-23 Maryam Saem , Ralph Brinks

Recently, we have shown that the age-specific prevalence of a disease can be related to the transition rates in the illness-death model via a partial differential equation (PDE). In case of a chronic disease, we show that the PDE can be…

Populations and Evolution · Quantitative Biology 2017-12-29 Ralph Brinks

In this work we examine the properties of a recently described ordinary differential equation that relates the age-specific prevalence of a chronic disease with the incidence and mortalities of the diseased and healthy persons. The equation…

Quantitative Methods · Quantitative Biology 2012-08-28 Ralph Brinks

This article describes a method to estimate the mortality rate ratio R from current status data with duration in a chronic condition in case the general mortality of the overall population is known. Apart from the general mortality, the…

Methodology · Statistics 2022-10-21 Ralph Brinks

This paper describes types of errors arising in a recently proposed method of incidence estimation from prevalence data. The errors are illustrated by a simulation study about a hypothetical irreversible disease. In addition, a way of…

Populations and Evolution · Quantitative Biology 2014-10-06 Ralph Brinks

This paper generalizes a previously published differential equation that describes the relation between the age-specific incidence, remission, and mortality of a disease with its prevalence. The underlying model is a simple compartment…

Populations and Evolution · Quantitative Biology 2012-09-07 Ralph Brinks

This paper descibes a new method of calculating the mean duration and mean age of onset of a chronic disease from incidence and mortality rates. It is based on an ordinary differential equation resulting from a simple compartment model.…

Quantitative Methods · Quantitative Biology 2011-12-30 Ralph Brinks

Aggregated health data such as claims data from health insurances become more and more available for research purposes. Estimates of excess mortality from prevalence and incidence of a chronic condition have only been possible for ages 50…

Populations and Evolution · Quantitative Biology 2019-08-13 Ralph Brinks

We study the relation between the age-specific prevalence, incidence and mortality in an illness-death model consisting of the three states Healthy, Ill, Dead. The dependency on three different time scales (age, calendar time, disease…

Populations and Evolution · Quantitative Biology 2016-06-28 Ralph Brinks

There have been significant efforts devoted to solving the longevity risk given that a continuous growth in population ageing has become a severe issue for many developed countries over the past few decades. The Cairns-Blake-Dowd (CBD)…

Applications · Statistics 2024-12-30 Ka Kin Lam , Bo Wang

A widely-used model for determining the long-term health impacts of public health interventions, often called a "multistate lifetable", requires estimates of incidence, case fatality, and sometimes also remission rates, for multiple…

Applications · Statistics 2023-03-23 Christopher Jackson , Belen Zapata-Diomedi , James Woodcock

Understanding age-group dynamics of infectious diseases is a fundamental issue for both scientific study and policymaking. Age-structure epidemic models were developed in order to study and improve our understanding of these dynamics. By…

Populations and Evolution · Quantitative Biology 2019-11-22 Rami Yaari , Amit Huppert , Itai Dattner

\noindent The modal age at death is an increasingly used measure for understanding longevity and mortality patterns. However, existing estimation methods focus on point estimates, overlooking the inherent variability and uncertainty in…

Applications · Statistics 2025-10-07 Silvio C. Patricio , Paola Vazquez-Castillo

New methods and theory have recently been developed to nonparametrically estimate cumulative incidence functions for competing risks survival data subject to current status censoring. In particular, the limiting distribution of the…

Methodology · Statistics 2012-01-12 Marloes H. Maathuis , Michael G. Hudgens

A MCMC approach is used to estimate the age-specific mortality rate ratio for German men and women with RA. For constructing priors, we calculate a range of admissible values from prevalence and incidence data based on about 60 million…

Other Quantitative Biology · Quantitative Biology 2023-02-24 Ralph Brinks

The aim of this article is relating the chemical master equation (CME) to the illness-death model for chronic diseases. We show that a recently developed differential equation for the prevalence directly follows from the CME. As an…

Biological Physics · Physics 2024-04-12 Ralph Brinks

For many diseases, logistic and other constraints often render large incidence studies difficult, if not impossible, to carry out. This becomes a drawback, particularly when a new incidence study is needed each time the disease incidence…

Methodology · Statistics 2008-08-11 Vittorio Addona , Masoud Asgharian , David B. Wolfson

Stochastic compartmental models are important tools for understanding the course of infectious diseases epidemics in populations and in prospective evaluation of intervention policies. However, calculating the likelihood for discretely…

Computation · Statistics 2018-07-26 Lam Si Tung Ho , Forrest W. Crawford , Marc A. Suchard
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