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Staining is essential in cell imaging and medical diagnostics but poses significant challenges, including high cost, time consumption, labor intensity, and irreversible tissue alterations. Recent advances in deep learning have enabled…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Ziwang Xu , Lanqing Guo , Satoshi Tsutsui , Shuyan Zhang , Alex C. Kot , Bihan Wen

Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining…

Using a deep neural network, we demonstrate a digital staining technique, which we term PhaseStain, to transform quantitative phase images (QPI) of labelfree tissue sections into images that are equivalent to brightfield microscopy images…

Image and Video Processing · Electrical Eng. & Systems 2019-02-08 Yair Rivenson , Tairan Liu , Zhensong Wei , Yibo Zhang , Aydogan Ozcan

The application of supervised deep learning methods in digital pathology is limited due to their sensitivity to domain shift. Digital Pathology is an area prone to high variability due to many sources, including the common practice of…

Image and Video Processing · Electrical Eng. & Systems 2020-12-24 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert

One highly promising direction for enabling flexible real-time on-device image editing is utilizing data distillation by leveraging large-scale text-to-image diffusion models to generate paired datasets used for training generative…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Yifan Gong , Zheng Zhan , Qing Jin , Yanyu Li , Yerlan Idelbayev , Xian Liu , Andrey Zharkov , Kfir Aberman , Sergey Tulyakov , Yanzhi Wang , Jian Ren

Generative Adversarial Networks (GANs) rely heavily on large-scale training data for training high-quality image generation models. With limited training data, the GAN discriminator often suffers from severe overfitting which directly leads…

Computer Vision and Pattern Recognition · Computer Science 2023-03-31 Kaiwen Cui , Yingchen Yu , Fangneng Zhan , Shengcai Liao , Shijian Lu1 , Eric Xing

Iterative generative models, such as noise conditional score networks and denoising diffusion probabilistic models, produce high quality samples by gradually denoising an initial noise vector. However, their denoising process has many…

Machine Learning · Computer Science 2021-01-08 Eric Luhman , Troy Luhman

An important part of Digital Pathology is the analysis of multiple digitised whole slide images from differently stained tissue sections. It is common practice to mount consecutive sections containing corresponding microscopic structures on…

Computer Vision and Pattern Recognition · Computer Science 2018-11-06 Thomas Lampert , Odyssée Merveille , Jessica Schmitz , Germain Forestier , Friedrich Feuerhake , Cédric Wemmert

Learning disentangled representation of data without supervision is an important step towards improving the interpretability of generative models. Despite recent advances in disentangled representation learning, existing approaches often…

Computer Vision and Pattern Recognition · Computer Science 2020-01-14 Wonkwang Lee , Donggyun Kim , Seunghoon Hong , Honglak Lee

Training deep neural networks has become increasingly demanding, requiring large datasets and significant computational resources, especially as model complexity advances. Data distillation methods, which aim to improve data efficiency,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Sunwoo Cho , Yejin Jung , Nam Ik Cho , Jae Woong Soh

The rapid growth of digital pathology in recent years has provided an ideal opportunity for the development of artificial intelligence-based tools to improve the accuracy and efficiency of clinical diagnoses. One of the significant…

Image and Video Processing · Electrical Eng. & Systems 2024-03-08 Jack Breen , Kieran Zucker , Katie Allen , Nishant Ravikumar , Nicolas M. Orsi

Image denoising plays a critical role in biomedical and microscopy imaging, especially when acquiring wide-field fluorescence-stained images. This task faces challenges in multiple fronts, including limitations in image acquisition…

Image and Video Processing · Electrical Eng. & Systems 2026-05-26 Qijun Yang , Yating Huang , Lintao Xiang , Hujun Yin

Biological imaging data are often partially confounded or contain unwanted variability. Examples of such phenomena include variable lighting across microscopy image captures, stain intensity variation in histological slides, and batch…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Craig A. Glastonbury , Michael Ferlaino , Christoffer Nellåker , Cecilia M. Lindgren

Improving the aesthetic quality of images is challenging and eager for the public. To address this problem, most existing algorithms are based on supervised learning methods to learn an automatic photo enhancer for paired data, which…

Computer Vision and Pattern Recognition · Computer Science 2021-01-06 Zhangkai Ni , Wenhan Yang , Shiqi Wang , Lin Ma , Sam Kwong

We consider unsupervised cell nuclei segmentation in this paper. Exploiting the recently-proposed unpaired image-to-image translation between cell nuclei images and randomly synthetic masks, existing approaches, e.g., CycleGAN, have…

Image and Video Processing · Electrical Eng. & Systems 2022-03-11 Kai Yao , Kaizhu Huang , Jie Sun , Curran Jude

Supervised deep learning algorithms have enabled significant performance gains in medical image classification tasks. But these methods rely on large labeled datasets that require resource-intensive expert annotation. Semi-supervised…

In recent years, image classification, as a core task in computer vision, relies on high-quality labelled data, which restricts the wide application of deep learning models in practical scenarios. To alleviate the problem of insufficient…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Jiyu Hu , Haijiang Zeng , Zhen Tian

Generative Adversarial Networks (GANs) have become a powerful approach for generative image modeling. However, GANs are notorious for their training instability, especially on large-scale, complex datasets. While the recent work of BigGAN…

Computer Vision and Pattern Recognition · Computer Science 2020-09-30 Ting-Yun Chang , Chi-Jen Lu

Deep learning based pan-sharpening has received significant research interest in recent years. Most of existing methods fall into the supervised learning framework in which they down-sample the multi-spectral (MS) and panchromatic (PAN)…

Computer Vision and Pattern Recognition · Computer Science 2022-06-15 Huanyu Zhou , Qingjie Liu , Dawei Weng , Yunhong Wang

Melanoma is a curable aggressive skin cancer if detected early. Typically, the diagnosis involves initial screening with subsequent biopsy and histopathological examination if necessary. Computer aided diagnosis offers an objective score…

Computer Vision and Pattern Recognition · Computer Science 2018-04-12 Xin Yi , Ekta Walia , Paul Babyn
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