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Deep learning models have become the dominant method for medical image segmentation. However, they often struggle to be generalisable to unknown tasks involving new anatomical structures, labels, or shapes. In these cases, the model needs…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Jing Xu

Foundation models (FMs) have transformed computational pathology by providing powerful, general-purpose feature extractors. However, adapting and benchmarking individual FMs for specific diagnostic tasks is often time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Peiran Quan , Zifan Gu , Zhuo Zhao , Qin Zhou , Donghan M. Yang , Ruichen Rong , Yang Xie , Guanghua Xiao

Pathological images play an essential role in cancer prognosis, while survival analysis, which integrates computational techniques, can predict critical clinical events such as patient mortality or disease recurrence from whole-slide images…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Guo Tang , Songhan Jiang , Jinpeng Lu , Linghan Cai , Yongbing Zhang

Whole slide image (WSI) has been widely used to assist automated diagnosis under the deep learning fields. However, most previous works only discuss the SINGLE task setting which is not aligned with real clinical setting, where pathologists…

Computer Vision and Pattern Recognition · Computer Science 2023-03-31 Weiqin Zhao , Shujun Wang , Maximus Yeung , Tianye Niu , Lequan Yu

Multiple Instance Learning (MIL) has emerged as the best solution for Whole Slide Image (WSI) classification. It consists of dividing each slide into patches, which are treated as a bag of instances labeled with a global label. MIL includes…

Computer Vision and Pattern Recognition · Computer Science 2025-05-05 Ali Mammadov , Loic Le Folgoc , Julien Adam , Anne Buronfosse , Gilles Hayem , Guillaume Hocquet , Pietro Gori

Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Foundation models have recently achieved impressive success in computational pathology, demonstrating strong generalization across diverse histopathology tasks. However, existing models overlook the heterogeneous and non-uniform…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Di Zhang , Zhangpeng Gong , Xiaobo Pang , Jiashuai Liu , Junbo Lu , Hao Cui , Jiusong Ge , Zhi Zeng , Kai Yi , Yinghua Li , Si Liu , Tingsong Yu , Haoran Wang , Mireia Crispin-Ortuzar , Weimiao Yu , Chen Li , Zeyu Gao

GPU technology has been improving at an expedited pace in terms of size and performance, empowering HPC and AI/ML researchers to advance the scientific discovery process. However, this also leads to inefficient resource usage, as most GPU…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-10-10 Baolin Li , Tirthak Patel , Siddarth Samsi , Vijay Gadepally , Devesh Tiwari

Regions of Interest (ROI) contain morphological features in pathology whole slide images (WSI) are delimited with polygons[1]. These polygons are often represented in either a textual notation (with the array of edges) or in a binary mask…

Graphics · Computer Science 2020-05-15 Erich Bremer , Jonas Almeida , Joel Saltz

In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Magdalini Paschali , Muhammad Ferjad Naeem , Walter Simson , Katja Steiger , Martin Mollenhauer , Nassir Navab

Segmenting histology images into diagnostically relevant regions is imperative to support timely and reliable decisions by pathologists. To this end, computer-aided techniques have been proposed to delineate relevant regions in scanned…

The richness in the content of various information networks such as social networks and communication networks provides the unprecedented potential for learning high-quality expressive representations without external supervision. This…

Machine Learning · Computer Science 2020-02-06 Zhen Peng , Wenbing Huang , Minnan Luo , Qinghua Zheng , Yu Rong , Tingyang Xu , Junzhou Huang

Whole slide image (WSI) classification is a critical task in computational pathology, requiring the processing of gigapixel-sized images, which is challenging for current deep-learning methods. Current state of the art methods are based on…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Jingwei Zhang , Saarthak Kapse , Ke Ma , Prateek Prasanna , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Effectively modeling multimodal spatial omics data is critical for understanding tissue complexity and underlying biological mechanisms. While spatial transcriptomics, proteomics, and epigenomics capture molecular features, they lack…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Yongjun Xiao , Dian Meng , Xinlei Huang , Yanran Liu , Shiwei Ruan , Ziyue Qiao , Xubin Zheng

In recent years, deep learning has successfully been applied to automate a wide variety of tasks in diagnostic histopathology. However, fast and reliable localization of small-scale regions-of-interest (ROI) has remained a key challenge, as…

Image and Video Processing · Electrical Eng. & Systems 2022-01-06 Jon Braatz , Pranav Rajpurkar , Stephanie Zhang , Andrew Y. Ng , Jeanne Shen

Accurate segmentation of cell nuclei in histopathology images is essential for numerous biomedical research and clinical applications. However, existing cell nucleus segmentation methods only consider a single dataset (i.e., primary…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Jiahe Qian , Yaoyu Fang , Jinkui Hao , Bo Zhou

Whole-slide images (WSIs) are fundamental for computational pathology, where accurate lesion segmentation is critical for clinical decision making. Existing methods partition WSIs into discrete patches, disrupting spatial continuity and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Yunheng Wu , Wenqi Huang , Liangyi Wang , Masahiro Oda , Yuichiro Hayashi , Daniel Rueckert , Kensaku Mori

Graph signal processing (GSP) has become an important tool in image processing because of its ability to reveal underlying data structures. Many real-life multimedia datasets, however, exhibit heterogeneous structures across frames.…

Signal Processing · Electrical Eng. & Systems 2022-04-20 Songyang Zhang , Qinwen Deng , Zhi Ding

Deep learning is a powerful tool for whole slide image (WSI) analysis. Typically, when performing supervised deep learning, a WSI is divided into small patches, trained and the outcomes are aggregated to estimate disease grade. However,…

Computer Vision and Pattern Recognition · Computer Science 2022-05-20 Yi Zheng , Rushin H. Gindra , Emily J. Green , Eric J. Burks , Margrit Betke , Jennifer E. Beane , Vijaya B. Kolachalama

Multiple instance learning (MIL) has been extensively applied to whole slide histopathology image (WSI) analysis. The existing aggregation strategy in MIL, which primarily relies on the first-order distance (e.g., mean difference) between…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Yihang Chen , Tsai Hor Chan , Guosheng Yin , Yuming Jiang , Lequan Yu
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