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We present a novel method for predicting binary phase diagrams through the automatic construction of a minimal basis set of representative templates. The core assumption is that any materials space can be divided into a small number of…

Materials Science · Physics 2024-10-03 Caja Annweiler , Simone Di Cataldo , Maurits W. Haverkort , Lilia Boeri

Proteins are complex biomolecules that perform a variety of crucial functions within living organisms. Designing and generating novel proteins can pave the way for many future synthetic biology applications, including drug discovery.…

Biological sequence design (DNA, RNA, or peptides) with desired functional properties has applications in discovering novel nanomaterials, biosensors, antimicrobial drugs, and beyond. One common challenge is the ability to optimize complex…

Quantitative Methods · Quantitative Biology 2025-12-17 Elham Sadeghi , Xianqi Deng , I-Hsin Lin , Stacy M. Copp , Petko Bogdanov

Variational Quantum Circuits (VQC) lie at the forefront of quantum machine learning research. Still, the use of quantum networks for real data processing remains challenging as the number of available qubits cannot accommodate a large…

Quantum Physics · Physics 2024-09-06 G. Maragkopoulos , A. Mandilara , A. Tsili , D. Syvridis

Generative autoencoders offer a promising approach for controllable text generation by leveraging their latent sentence representations. However, current models struggle to maintain coherent latent spaces required to perform meaningful text…

Machine Learning · Computer Science 2020-07-08 Tianxiao Shen , Jonas Mueller , Regina Barzilay , Tommi Jaakkola

Machine learning models can assist with metamaterials design by approximating computationally expensive simulators or solving inverse design problems. However, past work has usually relied on black box deep neural networks, whose reasoning…

Machine Learning · Computer Science 2022-10-04 Zhi Chen , Alexander Ogren , Chiara Daraio , L. Catherine Brinson , Cynthia Rudin

Autoencoders are a widespread tool in machine learning to transform high-dimensional data into a lowerdimensional representation which still exhibits the essential characteristics of the input. The encoder provides an embedding from the…

Machine Learning · Computer Science 2021-04-28 Juliane Braunsmann , Marko Rajković , Martin Rumpf , Benedikt Wirth

Discovering novel stable molecules without training data remains a grand scientific challenge. Current molecular generative models are trained on large, pre-curated datasets, which introduce biases and limit exploration of novel chemistry.…

Machine Learning · Computer Science 2026-05-28 Bjarke Hastrup , Francois Cornet , Tejs Vegge , Arghya Bhowmik

Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the contents of cellular tomograms are often complex, making it difficult to…

Quantitative Methods · Quantitative Biology 2017-12-29 Xiangrui Zeng , Miguel Ricardo Leung , Tzviya Zeev-Ben-Mordehai , Min Xu

Given the complex geometry of white matter streamlines, Autoencoders have been proposed as a dimension-reduction tool to simplify the analysis streamlines in a low-dimensional latent spaces. However, despite these recent successes, the…

Machine Learning · Statistics 2023-11-21 Andrew Lizarraga , Brandon Taraku , Edouardo Honig , Ying Nian Wu , Shantanu H. Joshi

We propose a multi-layer variational autoencoder method, we call HR-VQVAE, that learns hierarchical discrete representations of the data. By utilizing a novel objective function, each layer in HR-VQVAE learns a discrete representation of…

Computer Vision and Pattern Recognition · Computer Science 2022-08-10 Mohammad Adiban , Kalin Stefanov , Sabato Marco Siniscalchi , Giampiero Salvi

Drug discovery projects entail cycles of design, synthesis, and testing that yield a series of chemically related small molecules whose properties, such as binding affinity to a given target protein, are progressively tailored to a…

Machine Learning · Computer Science 2020-02-10 Paul Maragakis , Hunter Nisonoff , Brian Cole , David E. Shaw

Representation learning for high-dimensional, complex physical systems aims to identify a low-dimensional intrinsic latent space, which is crucial for reduced-order modeling and modal analysis. To overcome the well-known Kolmogorov barrier,…

Machine Learning · Computer Science 2025-11-07 Nithin Somasekharan , Shaowu Pan

We present a method to increase the resolution of measurements of a physical system and subsequently predict its time evolution using thermodynamics-aware neural networks. Our method uses adversarial autoencoders, which reduce the…

Computational Physics · Physics 2024-07-24 Carlos Bermejo-Barbanoj , Beatriz Moya , Alberto Badías , Francisco Chinesta , Elías Cueto

Two-dimensional materials with flat electronic bands are promising for realizing exotic quantum phenomena such as unconventional superconductivity and nontrivial topology, but exploring their vast chemical space remains challenging. Here,…

Mesoscale and Nanoscale Physics · Physics 2025-02-24 Henry Kelbrick Pentz , Thomas Warford , Ivan Timokhin , Qian Yang , Anupam Bhattacharya , Artem Mishchenko

Current 3D-aware pretraining methods for embodied perception and manipulation are largely built on differentiable rendering frameworks, producing either fully implicit neural fields or fully explicit geometric primitives. Implicit…

The article explores an encoding and structural information processing approach using sparse bit vectors and fixed-length linear vectors. The following are presented: a discrete method of speculative stochastic dimensionality reduction of…

Machine Learning · Computer Science 2025-08-05 Dmitriy Kashitsyn , Dmitriy Shabanov

Autoencoders represent an effective approach for computing the underlying factors characterizing datasets of different types. The latent representation of autoencoders have been studied in the context of enabling interpolation between data…

Machine Learning · Computer Science 2020-10-23 Alon Oring , Zohar Yakhini , Yacov Hel-Or

Machine learning based methods have shown potential for optimizing existing molecules with more desirable properties, a critical step towards accelerating new chemical discovery. Here we propose QMO, a generic query-based molecule…

Machine Learning · Computer Science 2022-04-21 Samuel Hoffman , Vijil Chenthamarakshan , Kahini Wadhawan , Pin-Yu Chen , Payel Das

High-energy large-scale particle colliders produce data at high speed in the order of 1 terabytes per second in nuclear physics and petabytes per second in high-energy physics. Developing real-time data compression algorithms to reduce such…

Machine Learning · Statistics 2023-10-25 Yi Huang , Yihui Ren , Shinjae Yoo , Jin Huang
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