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RNA-seq has rapidly become the de facto technique to measure gene expression. However, the time required for analysis has not kept up with the pace of data generation. Here we introduce Sailfish, a novel computational method for quantifying…

Genomics · Quantitative Biology 2014-04-25 Rob Patro , Stephen M. Mount , Carl Kingsford

Transformers have been seldom employed in point cloud roof plane instance segmentation, which is the focus of this study, and existing superpoint Transformers suffer from limited performance due to the use of low-quality superpoints. To…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Cheng Zeng , Xiatian Qi , Chi Chen , Kai Sun , Wangle Zhang , Yuxuan Liu , Yan Meng , Bisheng Yang

Shortcuts, spurious rules that perform well during training but fail to generalize, present a major challenge to the reliability of deep networks (Geirhos et al., 2020). However, the impact of shortcuts on feature representations remains…

Machine Learning · Computer Science 2025-11-06 Nikita Tsoy , Nikola Konstantinov

Feature shifts between data sources are present in many applications involving healthcare, biomedical, socioeconomic, financial, survey, and multi-sensor data, among others, where unharmonized heterogeneous data sources, noisy data…

Machine Learning · Computer Science 2025-06-12 Míriam Barrabés , Daniel Mas Montserrat , Kapal Dev , Alexander G. Ioannidis

Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tissues and staining conditions. To address…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kazuya Nishimura , Ryoma Bise , Haruka Hirose , Yasuhiro Kojima

Medical image classification has developed rapidly under the impetus of the convolutional neural network (CNN). Due to the fixed size of the receptive field of the convolution kernel, it is difficult to capture the global features of…

Image and Video Processing · Electrical Eng. & Systems 2022-09-22 Xiangzuo Huo , Gang Sun , Shengwei Tian , Yan Wang , Long Yu , Jun Long , Wendong Zhang , Aolun Li

Identifying disease-indicative genes is critical for deciphering disease mechanisms and has attracted significant interest in biomedical research. Spatial transcriptomics offers unprecedented insights for the detection of disease-specific…

Methodology · Statistics 2024-09-05 Qicheng Zhao , Qihuang Zhang

Feature encoding is essential for point cloud analysis. In this paper, we propose a novel point convolution operator named Shell Point Convolution (SPConv) for shape encoding and local context learning. Specifically, SPConv splits 3D…

Computer Vision and Pattern Recognition · Computer Science 2021-09-27 Yuyan Li , Chuanmao Fan , Xu Wang , Ye Duan

High-resolution spatial transcriptomics platforms, such as Xenium, generate single-cell images that capture both molecular and spatial context, but their extremely high dimensionality poses major challenges for representation learning and…

In recent years, several works have adopted the convolutional neural network (CNN) to diagnose the avascular necrosis of the femoral head (AVNFH) based on X-ray images or magnetic resonance imaging (MRI). However, due to the tissue overlap,…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Lingfeng Li , Huaiwei Cong , Gangming Zhao , Junran Peng , Zheng Zhang , Jinpeng Li

Multi-instance learning is common for computer vision tasks, especially in biomedical image processing. Traditional methods for multi-instance learning focus on designing feature aggregation methods and multi-instance classifiers, where the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-18 Yanlun Tu , Houchao Lei , Wei Long , Yang Yang

Point cloud analysis is still a challenging task due to the disorder and sparsity of samplings of their geometric structures from 3D sensors. In this paper, we introduce the homotopy equivalence relation (HER) to make the neural networks…

Computer Vision and Pattern Recognition · Computer Science 2021-04-07 Linchao He , Mengting Luo , Dejun Zhang , Xiao Yang , Hu Chen , Yi Zhang

The study of biomolecular folding has been greatly advanced by single-molecule force spectroscopy (SMFS), which enables the observation of the dynamics of individual molecules. However, extracting quantitative models of fundamental…

Chemical Physics · Physics 2026-04-30 Lars Dingeldein , Aaron Lyons , Pilar Cossio , Michael Woodside , Roberto Covino

We propose a new framework that formulates point cloud registration as a denoising diffusion process from noisy transformation to object transformation. During training stage, object transformation diffuses from ground-truth transformation…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Yue Wu , Yongzhe Yuan , Xiaolong Fan , Xiaoshui Huang , Maoguo Gong , Qiguang Miao

FISH is a fast and simple ideal magneto-hydrodynamics code that scales to ~10 000 processes for a Cartesian computational domain of ~1000^3 cells. The simplicity of FISH has been achieved by the rigorous application of the operator…

Instrumentation and Methods for Astrophysics · Physics 2011-08-11 R. Kaeppeli , S. C. Whitehouse , S. Scheidegger , U. -L. Pen , M. Liebendoerfer

We present a novel deep learning framework for flow field predictions in irregular domains when the solution is a function of the geometry of either the domain or objects inside the domain. Grid vertices in a computational fluid dynamics…

Machine Learning · Computer Science 2021-09-20 Ali Kashefi , Davis Rempe , Leonidas J. Guibas

Understanding the implication of point cloud is still challenging to achieve the goal of classification or segmentation due to the irregular and sparse structure of point cloud. As we have known, PointNet architecture as a ground-breaking…

Computer Vision and Pattern Recognition · Computer Science 2020-09-29 Xi-An Li , Lei Zhang , Li-Yan Wang , Jian Lu

Fluorescence microscopy is essential in biological and medical research, providing critical insights into cellular structures. However, limited by optical diffraction and background noise, a substantial amount of hidden information is still…

Biological Physics · Physics 2026-04-14 Xiaofeng Zhang , Yongsheng Huang , Jielong Yang , Zhili Wang , Si Chen , Linbo Liu , Xin Ge

Localization in topological maps is essential for image-based navigation using an RGB camera. Localization using only one camera can be challenging in medium-to-large-sized environments because similar-looking images are often observed…

Robotics · Computer Science 2022-04-29 Takahiro Niwa , Shun Taguchi , Noriaki Hirose

Spiking Neural Networks (SNNs) offer an attractive and energy-efficient alternative to conventional Artificial Neural Networks (ANNs) due to their sparse binary activation. When SNN meets Transformer, it shows great potential in 2D image…

Machine Learning · Computer Science 2025-02-27 Peixi Wu , Bosong Chai , Hebei Li , Menghua Zheng , Yansong Peng , Zeyu Wang , Xuan Nie , Yueyi Zhang , Xiaoyan Sun