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Optical phase contains key information for biomedical and astronomical imaging. However, it is often obscured by layers of heterogeneous and scattering media, which render optical phase imaging at different depths an utmost challenge.…

In the study of the brain, there is a hypothesis that sparse coding is realized in information representation of external stimuli, which is experimentally confirmed for visual stimulus recently. However, unlike the specific functional…

Neurons and Cognition · Quantitative Biology 2023-12-15 Yusuke Endo , Koujin Takeda

Raman spectroscopy enables non-destructive, label-free molecular analysis with high specificity, making it a powerful tool for biomedical diagnostics. However, its application to biological tissues is challenged by inherently weak Raman…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Mengkun Chen , Sanidhya D. Tripathi , James W. Tunnell

Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment…

Applications · Statistics 2021-11-03 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

We study, using simulated experiments inspired by thin film magnetic domain patterns, the feasibility of phase retrieval in X-ray diffractive imaging in the presence of intrinsic charge scattering given only photon-shot-noise limited…

Materials Science · Physics 2011-01-25 Ne-Te Duane Loh , Stefan Eisebitt , Samuel Flewett , Veit Elser

Functional Magnetic Resonance Imaging (fMRI) is predominantly harnessed for spatially mapping activation foci along distributed pathways. However, resolving dynamic information on activation sequence remains elusive. Here, we show an…

Medical Physics · Physics 2020-02-04 Rita Gil , Francisca F. Fernandes , Noam Shemesh

Using optical speckle scanning microscopy [1], we demonstrate that clear images of multiple cells can be obtained through biological scattering tissue, with subcellular resolution and good image quality, as long as the size of the imaging…

Optics · Physics 2023-07-19 Xin Yang , Ye Pu , Demetri Psaltis

Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be…

Optics · Physics 2021-07-07 Ivan Vishniakou , Johannes D. Seelig

Random scattering of light in disordered media is an intriguing phenomenon of fundamental relevance to various applications. While techniques such as wavefront shaping and transmission matrix measurements have enabled remarkable progress…

This work is concerned with optical imaging in strongly diffusive environments. We consider a typical setting in optical coherence tomography where a sample is probed by a collection of wavefields produced by a laser and propagating through…

Optics · Physics 2024-12-10 Randy Bartels , Olivier Pinaud , Maxine Varughese

We present Frequency Marching, FM, an algorithm that refines three-dimensional electron density distributions from solution X-ray scattering data in both the small- and wide-angle regimes. This algorithm is based on a series of optimization…

Biological Physics · Physics 2020-12-25 Yen-Lin Chen , Lois Pollack

Image Segmentation is one of the core tasks in Computer Vision and solving it often depends on modeling the image appearance data via the color distributions of each it its constituent regions. Whereas many segmentation algorithms handle…

Computer Vision and Pattern Recognition · Computer Science 2025-02-06 Jeova Farias Sales Rocha Neto

Optical wavefront-shaping has emerged as a powerful tool to manipulate light in strongly scattering media. It enables diffraction-limited focusing and imaging at depths where conventional microscopy techniques fail. However, while most…

Optics · Physics 2014-03-04 T. Chaigne , O. Katz , A. C. Boccara , M. Fink , E. Bossy , S. Gigan

Neuroradiologists and neurosurgeons increasingly opt to use functional magnetic resonance imaging (fMRI) to map functionally relevant brain regions for noninvasive presurgical planning and intraoperative neuronavigation. This application…

Methodology · Statistics 2023-06-07 Andrew S. Whiteman , Andreas J. Bartsch , Jian Kang , Timothy D. Johnson

Three-photon (3P) microscopy is getting traction due to its superior performance in deep tissues. Yet, aberrations and light scattering still pose one of the main limitations in the attainable depth ranges for high-resolution imaging. Here,…

Feature visualization has gained substantial popularity, particularly after the influential work by Olah et al. in 2017, which established it as a crucial tool for explainability. However, its widespread adoption has been limited due to a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-11 Thomas Fel , Thibaut Boissin , Victor Boutin , Agustin Picard , Paul Novello , Julien Colin , Drew Linsley , Tom Rousseau , Rémi Cadène , Lore Goetschalckx , Laurent Gardes , Thomas Serre

Recent progress in generative models has made it easier for a wide audience to edit and create image content, raising concerns about the proliferation of deepfakes, especially in healthcare. Despite the availability of numerous techniques…

Image and Video Processing · Electrical Eng. & Systems 2024-10-22 Fred Grabovski , Lior Yasur , Guy Amit , Yisroel Mirsky

Optical imaging plays a crucial role in advancing science and technology, enabling applications in fields ranging from biomedicine to astronomy. However, imaging through scattering media such as biological tissues, fog, or turbulent…

When light travels through scattering media, speckles (spatially random distribution of fluctuated intensities) are formed due to the interference of light travelling along different optical paths, preventing the perception of structure,…

Optics · Physics 2020-06-15 Honglin Liu , Xin Wang , Puxiang Lai , Zhentao Liu , Jianhong Shi , Shensheng Han

Reliable analysis of intracellular dynamic processes in time-lapse fluorescence microscopy images requires complete and accurate tracking of all small particles in all time frames of the image sequences. A fundamental first step towards…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Yao Yao , Ihor Smal , Ilya Grigoriev , Anna Akhmanova , Erik Meijering