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Access to electronic health records (EHRs) for digital health research is often limited by privacy regulations and institutional barriers. Synthetic EHRs have been proposed as a way to enable safe and sovereign data sharing; however,…

Machine Learning · Computer Science 2026-03-10 Guanglin Zhou , Armin Catic , Motahare Shabestari , Matthew Young , Chaiquan Li , Katrina Poppe , Sebastiano Barbieri

In this paper, we propose a diffusion probabilistic model for handwriting generation. Diffusion models are a class of generative models where samples start from Gaussian noise and are gradually denoised to produce output. Our method of…

Machine Learning · Computer Science 2020-11-16 Troy Luhman , Eric Luhman

Data imputation and data generation have important applications for many domains, like healthcare and finance, where incomplete or missing data can hinder accurate analysis and decision-making. Diffusion models have emerged as powerful…

Machine Learning · Computer Science 2025-06-10 Mario Villaizán-Vallelado , Matteo Salvatori , Carlos Segura , Ioannis Arapakis

Accurate pain expression synthesis is essential for improving clinical training and human-robot interaction. Current Robotic Patient Simulators (RPSs) lack realistic pain facial expressions, limiting their effectiveness in medical training.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Quang Tien Dam , Tri Tung Nguyen Nguyen , Yuki Endo , Dinh Tuan Tran , Joo-Ho Lee

The present study introduces an innovative approach to the synthesis of Electroencephalogram (EEG) signals by integrating diffusion models with reinforcement learning. This integration addresses key challenges associated with traditional…

Signal Processing · Electrical Eng. & Systems 2024-10-02 Yang An , Yuhao Tong , Weikai Wang , Steven W. Su

Recent advances in deep generative models have greatly expanded the potential to create realistic synthetic health datasets. These synthetic datasets aim to preserve the characteristics, patterns, and overall scientific conclusions derived…

Machine Learning · Computer Science 2024-07-04 Jennifer A Bartell , Sander Boisen Valentin , Anders Krogh , Henning Langberg , Martin Bøgsted

Preservation of private user data is of paramount importance for high Quality of Experience (QoE) and acceptability, particularly with services treating sensitive data, such as IT-based health services. Whereas anonymization techniques were…

Machine Learning · Computer Science 2024-03-04 Navid Ashrafi , Vera Schmitt , Robert P. Spang , Sebastian Möller , Jan-Niklas Voigt-Antons

Deep learning in cardiac MRI (CMR) is fundamentally constrained by both data scarcity and privacy regulations. This study systematically benchmarks three generative architectures: Denoising Diffusion Probabilistic Models (DDPM), Latent…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Madhura Edirisooriya , Dasuni Kawya , Ishan Kumarasinghe , Isuri Devindi , Mary M. Maleckar , Roshan Ragel , Isuru Nawinne , Vajira Thambawita

The diffusion model has recently emerged as a potent approach in computer vision, demonstrating remarkable performances in the field of generative artificial intelligence. Capable of producing high-quality synthetic images, diffusion models…

Image and Video Processing · Electrical Eng. & Systems 2025-05-14 Abdullah , Tao Huang , Ickjai Lee , Euijoon Ahn

Deep learning models have demonstrated high-quality performance in areas such as image classification and speech processing. However, creating a deep learning model using electronic health record (EHR) data, requires addressing particular…

Machine Learning · Computer Science 2020-03-06 Amirsina Torfi , Edward A. Fox

Denoising diffusion probabilistic models (DDPMs) have achieved impressive performance on various image generation tasks, including image super-resolution. By learning to reverse the process of gradually diffusing the data distribution into…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Kai Zhao , Alex Ling Yu Hung , Kaifeng Pang , Haoxin Zheng , Kyunghyun Sung

The ongoing technological revolution in measurement systems enables the acquisition of high-resolution samples in fields such as engineering, biology, and medicine. However, these observations are often subject to errors from measurement…

Methodology · Statistics 2025-01-03 Mingyang Yi , Marcos Matabuena , Ruoyu Wang

Objective: To enable privacy-preserving learning of high quality generative and discriminative machine learning models from distributed electronic health records. Methods and Results: We describe general and scalable strategy to build…

Cryptography and Security · Computer Science 2018-06-19 Marina Blanton , Ah Reum Kang , Subhadeep Karan , Jaroslaw Zola

Denoising diffusion models are a powerful type of generative models used to capture complex distributions of real-world signals. However, their applicability is limited to scenarios where training samples are readily available, which is not…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Ayush Tewari , Tianwei Yin , George Cazenavette , Semon Rezchikov , Joshua B. Tenenbaum , Frédo Durand , William T. Freeman , Vincent Sitzmann

Advancements in AI for medical imaging offer significant potential. However, their applications are constrained by the limited availability of data and the reluctance of medical centers to share it due to patient privacy concerns.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Marvin Seyfarth , Salman Ul Hassan Dar , Isabelle Ayx , Matthias Alexander Fink , Stefan O. Schoenberg , Hans-Ulrich Kauczor , Sandy Engelhardt

Researchers require timely access to real-world longitudinal electronic health records (EHR) to develop, test, validate, and implement machine learning solutions that improve the quality and efficiency of healthcare. In contrast, health…

Machine Learning · Computer Science 2020-12-21 Siddharth Biswal , Soumya Ghosh , Jon Duke , Bradley Malin , Walter Stewart , Jimeng Sun

Denoising diffusion models, a class of generative models, have garnered immense interest lately in various deep-learning problems. A diffusion probabilistic model defines a forward diffusion stage where the input data is gradually perturbed…

Image and Video Processing · Electrical Eng. & Systems 2023-06-06 Amirhossein Kazerouni , Ehsan Khodapanah Aghdam , Moein Heidari , Reza Azad , Mohsen Fayyaz , Ilker Hacihaliloglu , Dorit Merhof

Currently, medical image domain translation operations show a high demand from researchers and clinicians. Amongst other capabilities, this task allows the generation of new medical images with sufficiently high image quality, making them…

Image and Video Processing · Electrical Eng. & Systems 2024-03-08 Cristiana Tiago , Sten Roar Snare , Jurica Sprem , Kristin McLeod

Electronic Health Record (EHR) data can be represented as discrete counts over a high dimensional set of possible procedures, diagnoses, and medications. Supervised topic models present an attractive option for incorporating EHR data as…

Machine Learning · Computer Science 2019-11-21 Jason Ren , Russell Kunes , Finale Doshi-Velez

Probabilistic denoising diffusion models (DDMs) have set a new standard for 2D image generation. Extending DDMs for 3D content creation is an active field of research. Here, we propose TetraDiffusion, a diffusion model that operates on a…

Computer Vision and Pattern Recognition · Computer Science 2024-08-12 Nikolai Kalischek , Torben Peters , Jan D. Wegner , Konrad Schindler
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