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This work presents the development and evaluation of an NLP-enabled probabilistic classifier designed to estimate the probability of technical and regulatory success (pTRS) for clinical trials in the field of neuroscience. While…

Machine Learning · Computer Science 2025-12-02 Michael R. Doane

Algorithms and technologies are essential tools that pervade all aspects of our daily lives. In the last decades, health care research benefited from new computer-based recruiting methods, the use of federated architectures for data…

Computers and Society · Computer Science 2023-01-26 Chiara Criscuolo , Tommaso Dolci , Mattia Salnitri

Importance: Social determinants of health (SDOH) are known to be associated with increased risk of suicidal behaviors, but few studies utilized SDOH from unstructured electronic health record (EHR) notes. Objective: To investigate…

The identification of key factors such as medications, diseases, and relationships within electronic health records and clinical notes has a wide range of applications in the clinical field. In the N2C2 2022 competitions, various tasks were…

Computation and Language · Computer Science 2023-06-14 Shouvon Sarker , Lijun Qian , Xishuang Dong

With the increasing availability of electronic health records (EHR) linked with biobank data for translational research, a critical step in realizing its potential is to accurately classify phenotypes for patients. Existing approaches to…

Methodology · Statistics 2024-04-02 Molei Liu , Xinyi Wang , Chuan Hong

This study evaluated the effect of BioBERT in medical text processing for the task of medical named entity recognition. Through comparative experiments with models such as BERT, ClinicalBERT, SciBERT, and BlueBERT, the results showed that…

Computation and Language · Computer Science 2024-12-12 Jiacheng Hu , Runyuan Bao , Yang Lin , Hanchao Zhang , Yanlin Xiang

Various deep learning algorithms have been developed to analyze different types of clinical data including clinical text classification and extracting information from 'free text' and so on. However, automate the keyword extraction from the…

Computation and Language · Computer Science 2019-10-25 Matthew Tang , Priyanka Gandhi , Md Ahsanul Kabir , Christopher Zou , Jordyn Blakey , Xiao Luo

The widespread adoption of Electronic Health Records (EHR) has significantly increased the amount of available healthcare data. This has allowed models inspired by Natural Language Processing (NLP) and Computer Vision, which scale…

Supervised Fine-Tuning (SFT) of the language backbone plays a pivotal role in adapting Vision-Language Models (VLMs) to specialized domains such as medical reasoning. However, existing SFT practices often rely on unfiltered textual datasets…

Computation and Language · Computer Science 2026-03-17 Xinlin Zhuang , Feilong Tang , Haolin Yang , Xiwei Liu , Ming Hu , Huifa Li , Haochen Xue , Junjun He , Zongyuan Ge , Yichen Li , Ying Qian , Imran Razzak

ClinicalEncoder26AM is a multilingual Diagnosable ColBERT for clinical and biomedical texts, which aligns at multiple levels its token-level semantic with ClinicalMap25, a clinical latent space inspired by BioLORD-2023 and enriched with…

Computation and Language · Computer Science 2026-05-28 François Remy

Metaheuristic algorithms are optimization methods that are inspired by real phenomena in nature or the behavior of living beings, e.g., animals, to be used for solving complex problems, as in engineering, energy optimization, health care,…

Neural and Evolutionary Computing · Computer Science 2025-06-16 Ardalan H. Awlla , Tarik A. Rashid , Ronak M. Abdullah

Background and Objective: Biomedical Named Entity Recognition (BioNER) is a foundational task in medical informatics, crucial for downstream applications like drug discovery and clinical trial matching. However, adapting general-domain…

Computation and Language · Computer Science 2025-12-30 Jian Chen , Leilei Su , Cong Sun

A great deal of effort has been devoted to discovering a particular genetic disorder, but its classification across a broad spectrum of disorder classes and types remains elusive. Early diagnosis of genetic disorders enables timely…

Artificial Intelligence · Computer Science 2024-12-04 Abu Bakar Siddik , Faisal R. Badal , Afroza Islam

Learning agents can make use of Reinforcement Learning (RL) to decide their actions by using a reward function. However, the learning process is greatly influenced by the elect of values of the hyperparameters used in the learning…

Robotics · Computer Science 2022-11-03 Adarsh Sehgal , Nicholas Ward , Hung La , Sushil Louis

Genetic algorithms are heuristic optimization techniques inspired by Darwinian evolution, which are characterized by successfully finding robust solutions for optimization problems. Here, we propose a subroutine-based quantum genetic…

Quantum Physics · Physics 2024-06-07 Rubén Ibarrondo , Giancarlo Gatti , Mikel Sanz

In observational studies, the causal effect of a treatment may be confounded with variables that are related to both the treatment and the outcome of interest. In order to identify a causal effect, such studies often rely on the…

Methodology · Statistics 2017-10-17 Emma Persson , Jenny Häggström , Ingeborg Waernbaum , Xavier de Luna

Background: Huntington's disease (HD) is a rare, genetically determined brain disorder that limits the life of the patient, although early prognosis of HD can substantially improve the patient's quality of life. Current HD prognosis methods…

Signal Processing · Electrical Eng. & Systems 2023-02-09 Sucheer Maddury

We present a genetic algorithm framework for automatically discovering deep learning optimization algorithms. Our approach encodes optimizers as genomes that specify combinations of primitive update terms (gradient, momentum, RMS…

Neural and Evolutionary Computing · Computer Science 2025-12-16 Mitchell Marfinetz

A key challenge in the application of evolutionary algorithms in practice is the selection of an algorithm instance that best suits the problem at hand. What complicates this decision further is that different algorithms may be best suited…

Neural and Evolutionary Computing · Computer Science 2021-02-15 Furong Ye , Carola Doerr , Thomas Bäck

Understanding how human health changes over time, and why responses to interventions vary between individuals, remains a central challenge in medicine. Here we present HealthFormer, a decoder-only transformer that models the human…

Artificial Intelligence · Computer Science 2026-05-01 Guy Lutsker , Gal Sapir , Jordi Merino , Smadar Shilo , Anastasia Godneva , Eli Meirom , Shie Mannor , Hagai Rossman , Gal Chechik , Eran Segal