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This has much in common with traditional work in statistics and machine learning. However, there are important new issues which arise because of the sheer size of the data. One of the important problem in data mining is the…

Databases · Computer Science 2009-11-05 Kanak Saxena , D. S Rajpoot

Convolutional Neural Networks (CNN) have gained great success in many artificial intelligence tasks. However, finding a good set of hyperparameters for a CNN remains a challenging task. It usually takes an expert with deep knowledge, and…

Neural and Evolutionary Computing · Computer Science 2020-06-25 Xueli Xiao , Ming Yan , Sunitha Basodi , Chunyan Ji , Yi Pan

The past decade has witnessed many great successes of machine learning (ML) and deep learning (DL) applications in agricultural systems, including weed control, plant disease diagnosis, agricultural robotics, and precision livestock…

Computer Vision and Pattern Recognition · Computer Science 2023-05-25 Jiajia Li , Dong Chen , Xinda Qi , Zhaojian Li , Yanbo Huang , Daniel Morris , Xiaobo Tan

In biomedical research, validation of a new scientific discovery is tied to the reproducibility of its experimental results. However, in genomics, the definition and implementation of reproducibility still remain imprecise. Here, we argue…

A central problem in comparative genomics consists in computing a (dis-)similarity measure between two genomes, e.g. in order to construct a phylogeny. All the existing measures are defined on genomes without duplicates. However, we know…

Quantitative Methods · Quantitative Biology 2008-12-18 Sébastien Angibaud , Guillaume Fertin , Irena Rusu , Annelyse Thevenin , Stéphane Vialette

Metagenomics characterizes the taxonomic diversity of microbial communities by sequencing DNA directly from an environmental sample. One of the main challenges in metagenomics data analysis is the binning step, where each sequenced read is…

Quantitative Methods · Quantitative Biology 2015-05-27 Kévin Vervier , Pierre Mahé , Maud Tournoud , Jean-Baptiste Veyrieras , Jean-Philippe Vert

In this paper we consider some of the issues of working with big data and big spatial data and highlight the need for an open and critical framework. We focus on a set of challenges underlying the collection and analysis of big data. In…

Computers and Society · Computer Science 2020-08-12 Chris Brunsdon , Alexis Comber

The fall of prices of the high-throughput genome sequencing changes the landscape of modern genomics. A number of large scale projects aimed at sequencing many human genomes are in progress. Genome sequencing also becomes an important aid…

Data Structures and Algorithms · Computer Science 2017-03-03 Sebastian Deorowicz , Agnieszka Danek , Marcin Niemiec

Current techniques in sequencing a genome allow a service provider (e.g. a sequencing company) to have full access to the genome information, and thus the privacy of individuals regarding their lifetime secret is violated. In this paper, we…

Genomics · Quantitative Biology 2018-11-28 Ali Gholami , Mohammad Ali Maddah-Ali , Seyed Abolfazl Motahari

Crops, fisheries and livestock form the backbone of global food production, essential to feed the ever-growing global population. However, these sectors face considerable challenges, including climate variability, resource limitations, and…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Umair Nawaz , Muhammad Zaigham Zaheer , Ufaq Khan , Fahad Shahbaz Khan , Hisham Cholakkal , Salman Khan , Rao Muhammad Anwer

In Search Based Software Engineering, Genetic Programming has been used for bug fixing, performance improvement and parallelisation of programs through the modification of source code. Where an evolutionary computation algorithm, such as…

Neural and Evolutionary Computing · Computer Science 2012-11-22 Brendan Cody-Kenny , Stephen Barrett

Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including…

Cryptography and Security · Computer Science 2015-06-18 Muhammad Naveed , Erman Ayday , Ellen W. Clayton , Jacques Fellay , Carl A. Gunter , Jean-Pierre Hubaux , Bradley A. Malin , XiaoFeng Wang

The design of novel protein sequences with targeted functionalities underpins a central theme in protein engineering, impacting diverse fields such as drug discovery and enzymatic engineering. However, navigating this vast combinatorial…

Biomolecules · Quantitative Biology 2024-02-19 Yiheng Zhu , Zitai Kong , Jialu Wu , Weize Liu , Yuqiang Han , Mingze Yin , Hongxia Xu , Chang-Yu Hsieh , Tingjun Hou

GitHub Copilot, an extension for the Visual Studio Code development environment powered by the large-scale language model Codex, makes automatic program synthesis available for software developers. This model has been extensively studied in…

Software Engineering · Computer Science 2021-11-16 Dominik Sobania , Martin Briesch , Franz Rothlauf

The reliance of organisations on computer networks is enabled by network programmability, which is typically achieved through Service Function Chaining. These chains virtualise network functions, link them, and programmatically embed them…

Neural and Evolutionary Computing · Computer Science 2025-12-11 Theviyanthan Krishnamohan , Lauritz Thamsen , Paul Harvey

Predicting the secondary structure of RNA is a core challenge in computational biology, essential for understanding molecular function and designing novel therapeutics. The field has evolved from foundational but accuracy-limited…

Biomolecules · Quantitative Biology 2026-05-20 Giuseppe Sacco , Giovanni Bussi , Guido Sanguinetti

De novo assembly is the process of reconstructing the genome sequence of an organism from sequencing reads. Genome sequences are essential to biology, and assembly has been a central problem in bioinformatics for four decades. Until…

Genomics · Quantitative Biology 2023-08-16 Heng Li , Richard Durbin

While artificial intelligence (AI) has become widespread, many commercial AI systems are not yet accessible to individual researchers nor the general public due to the deep knowledge of the systems required to use them. We believe that AI…

We study possible applications of artificial neural networks to examine the string landscape. Since the field of application is rather versatile, we propose to dynamically evolve these networks via genetic algorithms. This means that we…

High Energy Physics - Theory · Physics 2017-09-13 Fabian Ruehle

Optimizing a neural network's performance is a tedious and time taking process, this iterative process does not have any defined solution which can work for all the problems. Optimization can be roughly categorized into - Architecture and…

Machine Learning · Computer Science 2019-12-16 Siddhartha Dhar Choudhury , Shashank Pandey , Kunal Mehrotra