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Bacteria often form surface-bound communities, embedded in a self-produced extracellular matrix, called biofilms. Quantitative studies of their growth have typically focused on unconfined expansion above solid or semi-solid surfaces,…
In this paper, a free boundary problem modelling the growth of tumor is considered. The model includes two reaction-diffusion equations modelling the diffusion of nutrient and drug in the tumor and three hyperbolic equations describing the…
We consider a parabolic non-local free boundary problem that has been derived as a limit of a bulk-surface reaction-diffusion system which models cell polarization. In previous papers, we have established well-posedness of this problem and…
The dynamics of a free boundary problem for electrostatically actuated microelectromechanical systems (MEMS) is investigated. The model couples the electric potential to the deformation of the membrane, the deflection of the membrane being…
In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…
In this paper we present an individual-based mechanical model that describes the dynamics of two contiguous cell populations with different proliferative and mechanical characteristics. An off-lattice modelling approach is considered…
The problem of stabilization of a system of coupled PDEs of the forth-order by means of boundary control is investigated. The considered setup arises from the classical Euler-Bernoulli beam model, and constitutes a generalization of…
We investigate the global existence of weak solutions to a free boundary problem governing the evolution of finitely extensible bead-spring chains in dilute polymers. The free boundary in the present context is defined with regard to a…
We study a class of lubrication-type equations modeling the spread of thin poroelastic biofilms at air/agar interfaces. Starting from a biofilm slab model, we perform a formal multi-scale asymptotic expansion to derive a reduced nonlinear…
Theoretical understanding of evolutionary dynamics in spatially structured populations often relies on non-spatial models. Biofilms are among such populations where a more accurate understanding is of theoretical interest and can reveal new…
A class of diffusion driven Free Boundary Problems is considered which is characterized by the initial onset of a phase and by an explicit kinematic condition for the evolution of the free boundary. By a domain fixing change of variables it…
We study a free boundary problem modelling the growth of non-necrotic tumors with fluid-like tissues. The fluid velocity satisfies Stokes equations with a source determined by the proliferation rate of tumor cells which depends on the…
We capture optimal decay for the Mullins-Sekerka evolution, a nonlocal, parabolic free boundary problem from materials science. Our main result establishes convergence of BV solutions to the planar profile in the physically relevant case of…
We consider a velocity field with linear viscous interactions defined on a one dimensional lattice. Brownian baths with different parameters can be coupled to the boundary sites and to the bulk sites, determining different kinds of…
We investigate a mathematical model for a bacterial population in a continuously stirred tank reactor with wall attachment. The model couples a free-boundary value problem for substrate diffusion in the one-dimensional biofilm with a system…
Electrostatic forces play many important roles in molecular biology, but are hard to model due to the complicated interactions between biomolecules and the surrounding solvent, a fluid composed of water and dissolved ions. Continuum model…
This paper is concerned with a nonlinear free boundary problem modeling the growth of spherically symmetric tumors with angiogenesis, set with a Robin boundary condition. In which, both nonnecrotic tumors and necrotic tumors are taken into…
In this paper, we study a free boundary problem for a class of parabolic-elliptic type chemotaxis model in high dimensional symmetry domain \Omega. By using the contraction mapping principle and operator semigroup approach, we establish the…
A free boundary problem for the dynamics of a glasslike binary fluid naturally leads to a singular perturbation problem for a strongly degenerate parabolic partial differential equation in 1D. We present a conjecture for an asymptotic…
At the continuous level, we consider two types of tumor growth models: the cell density model, which is based on the fluid mechanical construction, is more favorable for scientific interpretation and numerical simulations; and the free…