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A multiscale mathematical model is presented to describe the de novo granulation and the evolution of multispecies granular biofilms within a continuous reactor. The granule is modelled as a spherical free boundary domain with radial…

Populations and Evolution · Quantitative Biology 2022-02-02 A. Tenore , F. Russo , M. R. Mattei , B. D'Acunto , G. Collins , L. Frunzo

The dynamics of biofilm lifecycle are deeply influenced by the surrounding environment and the interactions between sessile and planktonic phenotypes. Bacterial biofilms typically develop in three distinct stages: attachment of cells to a…

Analysis of PDEs · Mathematics 2021-07-07 B. D'Acunto , L. Frunzo , V. Luongo , M. R. Mattei , A. Tenore

The work presents the analysis of the free boundary value problem related to the invasion model of new species in biofilm reactors. In the framework of continuum approach to mathematical modelling of biofilm growth, the problem consists of…

Biological Physics · Physics 2021-04-09 Berardino D'Acunto , Luigi Frunzo , Vincenzo Luongo , Maria Rosaria Mattei

A multiscale mathematical model describing the genesis and ecology of algal-bacterial photogranules and the metals biosorption on their solid matrix within a sequencing batch reactor (SBR) is presented. The granular biofilm is modelled as a…

Cell Behavior · Quantitative Biology 2023-01-31 F. Russo , A. Tenore , M. R. Mattei , L. Frunzo

We present the stability analysis of two free boundary problems arising in biofilm modelling. The first, introduced in the 1980s by Wanner and Gujer, is related to the competition between autotrophic and heterotrophic bacteria in a biofilm…

Analysis of PDEs · Mathematics 2025-03-26 Dieudonné Zirhumanana Balike , Maria Rosaria Mattei , Luigi Frunzo

This work presents the existence and uniqueness of solution to a free boundary value problem related to biofilm growth. The problem consists of a system of nonlinear hyperbolic partial differential equations governing the microbial species…

Analysis of PDEs · Mathematics 2025-03-26 Dieudonné Zirhumanana Balike , Luigi Frunzo , Maria Rosaria Mattei , Fabiana Russo

In this paper a reduced one-dimensional moving boundary model is studied that describes the evolution of a biofilm driven by the presence of a reaction limiting substrate. Global well-posedness is established for the resulting parabolic…

Analysis of PDEs · Mathematics 2025-05-30 Patrick Guidotti , Christoph Walker

This work presents a mathematical model which describes both the genesis and growth of oxygenic photogranules (OPGs) and the related treatment process. The photogranule has been modelled as a free boundary domain with radial symmetry, which…

Populations and Evolution · Quantitative Biology 2021-04-27 A. Tenore , M. R. Mattei , L. Frunzo

A mathematical model for emerging contaminants sorption in multispecies biofilms, based on a continuum approach and mass conservation principles is presented. Diffusion of contaminants within the biofilm is described using a…

Cell Behavior · Quantitative Biology 2017-06-15 Luigi Frunzo

In this volume a theory for models of transport in the presence of a free boundary is developed. Macroscopic laws of transport are described by PDEs. When the system is open, there are several mechanisms to couple the system with the…

Probability · Mathematics 2016-07-28 Gioia Carinci , Anna De Masi , Cristian Giardinà , Errico Presutti

We prove an existence result for a free boundary problem inspired by the modelization of accretive growth. The growth process is formulated through a level-set approach, leading to a boundary-value problem for a Hamilton-Jacobi equation…

Analysis of PDEs · Mathematics 2026-02-17 Ulisse Stefanelli

We introduce a free boundary model to example the effect of vesicle transport onto neurite growth. It consists of systems of drift-diffusion equations describing the evolution of the density of antero- and retrograde vesicles in each…

Analysis of PDEs · Mathematics 2025-11-26 Greta Marino , Jan-Frederik Pietschmann , Max Winkler

Two phase solid-fluid mixture models are ubiquitous in biological applications. For instance, models for growth of tissues and biofilms combine time dependent and quasi-stationary boundary value problems set in domains whose boundary moves…

Analysis of PDEs · Mathematics 2024-01-17 Ana Carpio , Gema Duro

We consider a free boundary problem for a system of PDEs, modeling the growth of a biological tissue. A morphogen, controlling volume growth, is produced by specific cells and then diffused and absorbed throughout the domain. The geometric…

Analysis of PDEs · Mathematics 2017-11-22 Alberto Bressan , Marta Lewicka

In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…

Analysis of PDEs · Mathematics 2018-08-24 Rui Li , Bei Hu

In this paper we consider a system of two coupled nonlinear diffusion--reaction partial differential equations (PDEs) which model the growth of biofilm and consumption of the nutrient. At the scale of interest the biofilm density is subject…

Numerical Analysis · Mathematics 2020-01-03 Azhar Alhammali , Malgorzata Peszynska

The dynamical and stationary behaviors of a fourth-order evolution equation with clamped boundary conditions and a singular nonlocal reaction term, which is coupled to an elliptic free boundary problem on a non-smooth domain, are…

Analysis of PDEs · Mathematics 2013-08-29 Philippe Laurencot , Christoph Walker

In this paper, we study a nonlinear free boundary problem modeling the growth of spherically symmetric tumors. The tumor consists of a central necrotic core, an intermediate annual quiescent-cell layer, and an outer proliferating-cell…

Analysis of PDEs · Mathematics 2025-11-04 Junde Wu , Hao Xu , Yuehong Zhuang

Well-posedness of a free boundary problem for electrostatic microelectromechanical systems (MEMS) is investigated when nonlinear bending effects are taken into account. The model describes the evolution of the deflection of an electrically…

Analysis of PDEs · Mathematics 2014-09-26 Philippe Laurencot , Christoph Walker

A variational approach is employed to find stationary solutions to a free boundary problem modeling an idealized electrostatically actuated MEMS device made of an elastic plate coated with a thin dielectric film and suspended above a rigid…

Analysis of PDEs · Mathematics 2014-09-10 Philippe Laurencot , Christoph Walker
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