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We present a new instance segmentation approach tailored to biological images, where instances may correspond to individual cells, organisms or plant parts. Unlike instance segmentation for user photographs or road scenes, in biological…

Computer Vision and Pattern Recognition · Computer Science 2020-04-24 Victor Kulikov , Victor Lempitsky

To address the issues of MixUp and its variants (e.g., Manifold MixUp) in image classification tasks-namely, their neglect of mixing within the same class (intra-class mixup) and their inadequacy in enhancing intra-class cohesion through…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Ye Xu , Ya Gao , Xiaorong Qiu , Yang Chen , Ying Ji

Oculomics - the concept of predicting systemic diseases, such as cardiovascular disease and dementia, through retinal imaging - has advanced rapidly due to the data efficiency of transformer-based foundation models like RETFound.…

Machine Learning · Computer Science 2026-01-29 Hyunmin Kim , Yukun Zhou , Rahul A. Jonas , Lie Ju , Sunjin Hwang , Pearse A. Keane , Siegfried K. Wagner

Due to the high cost of annotation or the rarity of some diseases, medical image segmentation is often limited by data scarcity and the resulting overfitting problem. Self-supervised learning and semi-supervised learning can mitigate the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Danyang Sun , Fadi Dornaika , Nagore Barrena

This paper proposes a simple yet effective interpolation-based data augmentation approach termed DoubleMix, to improve the robustness of models in text classification. DoubleMix first leverages a couple of simple augmentation operations to…

Computation and Language · Computer Science 2022-09-13 Hui Chen , Wei Han , Diyi Yang , Soujanya Poria

An automated segmentation and classification of nuclei is an essential task in digital pathology. The current deep learning-based approaches require a vast amount of annotated datasets by pathologists. However, the existing datasets are…

Image and Video Processing · Electrical Eng. & Systems 2022-10-25 Tan Nhu Nhat Doan , Kyungeun Kim , Boram Song , Jin Tae Kwak

Digital pathology has revolutionized the field by enabling the digitization of tissue samples into whole slide images (WSIs). However, the high resolution and large size of WSIs present significant challenges when it comes to applying Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Ali Mammadov , Loïc Le Folgoc , Guillaume Hocquet , Pietro Gori

Multiple Instance Learning (MIL) is widely used in analyzing histopathological Whole Slide Images (WSIs). However, existing MIL methods do not explicitly model the data distribution, and instead they only learn a bag-level or instance-level…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Linhao Qu , Xiaoyuan Luo , Shaolei Liu , Manning Wang , Zhijian Song

Deep learning-based models, when trained in a fully-supervised manner, can be effective in performing complex image analysis tasks, although contingent upon the availability of large labeled datasets. Especially in the medical imaging…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Ayaan Haque , Abdullah-Al-Zubaer Imran , Adam Wang , Demetri Terzopoulos

Building a virtual cell capable of accurately simulating cellular behaviors in silico has long been a dream in computational biology. We introduce CellFlux, an image-generative model that simulates cellular morphology changes induced by…

Multiple instance learning is an ideal mode of analysis for histopathology data, where vast whole slide images are typically annotated with a single global label. In such cases, a whole slide image is modelled as a collection of tissue…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Leo Fillioux , Joseph Boyd , Maria Vakalopoulou , Paul-Henry Cournède , Stergios Christodoulidis

We propose a general framework for a collaborative machine learning system to assist bioscience researchers with the task of labeling specific cell identities from microscopic still or video imaging. The distinguishing features of this…

Quantitative Methods · Quantitative Biology 2019-03-25 Greg Bubnis , Steven Ban , Matthew D. DiFranco , Saul Kato

Learning medical visual representations from image-report pairs through joint learning has garnered increasing research attention due to its potential to alleviate the data scarcity problem in the medical domain. The primary challenges stem…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Jun Wang , Lixing Zhu , Xiaohan Yu , Abhir Bhalerao , Yulan He

Data mixing augmentation has proved effective in training deep models. Recent methods mix labels mainly based on the mixture proportion of image pixels. As the main discriminative information of a fine-grained image usually resides in…

Computer Vision and Pattern Recognition · Computer Science 2020-12-10 Shaoli Huang , Xinchao Wang , Dacheng Tao

Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is a common solution for working with high resolution…

Malignant lymphoma subtype classification directly impacts treatment strategies and patient outcomes, necessitating classification models that achieve both high accuracy and sufficient explainability. This study proposes a novel explainable…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Daiki Nishiyama , Hiroaki Miyoshi , Noriaki Hashimoto , Koichi Ohshima , Hidekata Hontani , Ichiro Takeuchi , Jun Sakuma

Data augmentation for domain-specific image classification tasks often struggles to simultaneously address diversity, faithfulness, and label clarity of generated data, leading to suboptimal performance in downstream tasks. While existing…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Yixuan Dong , Fang-Yi Su , Jung-Hsien Chiang

For classifying digital whole slide images in the absence of pixel level annotation, typically multiple instance learning methods are applied. Due to the generic applicability, such methods are currently of very high interest in the…

Interpolation-based Data Augmentation (DA) methods (Mixup) linearly interpolate the inputs and labels of two or more training examples. Mixup has more recently been adapted to the field of Natural Language Processing (NLP), mainly for…

Computation and Language · Computer Science 2023-11-17 Yuxin Pei , Pushkar Bhuse , Zhengzhong Liu , Eric Xing

Data augmentation is a key technique for improving the robustness of image classification models. However, many recent approaches rely on diffusion-based synthesis or complex feature mixing strategies, which introduce substantial…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Yuto Matsuo , Yoshihiro Fukuhara , Yuki M. Asano , Rintaro Yanagi , Hirokatsu Kataoka , Akio Nakamura