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Parkinson's disease (PD), a degenerative disorder of the central nervous system, is commonly diagnosed using functional medical imaging techniques such as single-photon emission computed tomography (SPECT). In this study, we utilized two…

Machine Learning · Computer Science 2025-01-22 Guan-Hua Huang , Wan-Chen Lai , Tai-Been Chen , Chien-Chin Hsu , Huei-Yung Chen , Yi-Chen Wu , Li-Ren Yeh

The existing computational models used to estimate motion sickness are incapable of describing the fact that the predictability of motion patterns affects motion sickness. Therefore, the present study proposes a computational model to…

Quantitative Methods · Quantitative Biology 2021-01-18 Takahiro Wada

Current diagnosis and prognosis for Parkinson's disease (PD) face formidable challenges due to the heterogeneous nature of the disease course, including that (i) the impairment severity varies hugely between patients, (ii) whether a symptom…

Applications · Statistics 2024-10-03 Kai Kang , Yuqi Gu

Parkinson's disease is a neuro-degenerative disorder affecting tens of millions of people worldwide. Lately, there has been considerable interest in systems for at-home monitoring of patients, using wearable devices which contain inertial…

Applications · Statistics 2017-02-08 Avishai Wagner , Naama Fixler , Yehezkel S. Resheff

Tremor is a key diagnostic feature of Parkinson's Disease (PD), Essential Tremor (ET), and other central nervous system (CNS) disorders. Clinicians or trained raters assess tremor severity with TETRAS scores by observing patients. Lacking…

Computer Vision and Pattern Recognition · Computer Science 2021-05-05 Li Zhang , Vijay Yadav , Vidya Koesmahargyo , Anzar Abbas , Isaac Galatzer-Levy

Parkinson's Disease PD is a progressive neurodegenerative disorder that affects motor and cognitive functions with early diagnosis being critical for effective clinical intervention Electroencephalography EEG offers a noninvasive and…

In this paper, we study a novel problem: "automatic prescription recommendation for PD patients." To realize this goal, we first build a dataset by collecting 1) symptoms of PD patients, and 2) their prescription drug provided by…

Machine Learning · Computer Science 2020-08-03 Yinghuan Shi , Wanqi Yang , Kim-Han Thung , Hao Wang , Yang Gao , Yang Pan , Li Zhang , Dinggang Shen

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that…

Machine Learning · Computer Science 2020-05-08 Anirudh Som , Narayanan Krishnamurthi , Matthew Buman , Pavan Turaga

A particular challenge for disease progression modeling is the heterogeneity of a disease and its manifestations in the patients. Existing approaches often assume the presence of a single disease progression characteristics which is…

Machine Learning · Computer Science 2022-07-26 Taha Ceritli , Andrew P. Creagh , David A. Clifton

Parkinson's disease ranks as the second most prevalent neurodegenerative disorder globally. This research aims to develop a system leveraging Mixed Reality capabilities for tracking and assessing eye movements. In this paper, we present a…

Human-Computer Interaction · Computer Science 2024-06-04 Mateusz Daniol , Daria Hemmerling , Jakub Sikora , Pawel Jemiolo , Marek Wodzinski , Magdalena Wojcik-Pedziwiatr

Speech impairments in Parkinson's disease (PD) provide significant early indicators for diagnosis. While models for speech-based PD detection have shown strong performance, their interpretability remains underexplored. This study…

Sound · Computer Science 2024-11-14 Eleonora Mancini , Francesco Paissan , Paolo Torroni , Mirco Ravanelli , Cem Subakan

Parkinson's Disease (PD) affects over 10 million people globally, with speech impairments often preceding motor symptoms by years, making speech a valuable modality for early, non-invasive detection. While recent deep-learning models…

Sound · Computer Science 2025-08-29 Terry Yi Zhong , Cristian Tejedor-Garcia , Martha Larson , Bastiaan R. Bloem

Parkinson's disease (PD) shows heterogeneous, evolving brain-morphometry patterns. Modeling these longitudinal trajectories enables mechanistic insight, treatment development, and individualized 'digital-twin' forecasting. However, existing…

Machine Learning · Computer Science 2025-11-10 Xiaoda Wang , Yuji Zhao , Kaiqiao Han , Xiao Luo , Sanne van Rooij , Jennifer Stevens , Lifang He , Liang Zhan , Yizhou Sun , Wei Wang , Carl Yang

Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical,…

Image and Video Processing · Electrical Eng. & Systems 2019-09-11 Justin Quan , Lin Xu , Rene Xu , Tyrael Tong , Jean Su

Freezing of gait (FoG) is a common gait disability in Parkinson's disease, that usually appears in its advanced stage. Freeze episodes are associated with falls, injuries, and psychological consequences, negatively affecting the patients'…

Signal Processing · Electrical Eng. & Systems 2019-09-10 Spyroula Masiala , Willem Huijbers , Martin Atzmueller

Parkinson's disease (PD) is a neuro-degenerative disorder that affects movement, speech, and coordination. Timely diagnosis and treatment can improve the quality of life for PD patients. However, access to clinical diagnosis is limited in…

Computer Vision and Pattern Recognition · Computer Science 2024-02-19 Md. Zarif Ul Alam , Md Saiful Islam , Ehsan Hoque , M Saifur Rahman

Falls are common in people with Parkinson's disease (PD) and have detrimental effects which can lower the quality of life. While studies have been conducted to learn about falling in general, factors distinguishing injurious from…

Applications · Statistics 2019-10-08 Sarini Abdullah , James McGree , Nicole White , Kerrie Mengersen , Graham Kerr

Parkinson's disease (PD) is the second most frequent neurodegenerative disease with prevalence among general population reaching 0.1-1 %, and an annual incidence between 1.3-2.0/10000 inhabitants. The mean age at diagnosis of PD is 55 and…

A widely used test for the diagnosis of Parkinson's disease (PD) and Essential tremor (ET) is hand-drawn shapes,where the analysis is observationally performed by the examining neurologist. This method is subjective and is prone to bias…

Computer Vision and Pattern Recognition · Computer Science 2020-06-23 Nabeel Seedat , Vered Aharonson , Ilana Schlesinger

Decoding motor performance from brain signals offers promising avenues for adaptive deep brain stimulation (aDBS) for Parkinson's disease (PD). In a two-center cohort of 19 PD patients executing a drawing task, we decoded motor performance…