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The automated assembly and extension of dynamic network models using information extracted from literature are challenging due to the amount and inconsistency in published literature. Recently, efforts have been made to automatically and…

Molecular Networks · Quantitative Biology 2021-10-22 Yasmine Ahmed , Adam A Butchy , Khaled Sayed , Cheryl Telmer , Natasa Miskov-Zivanov

We introduce and analyze the problem of the compilation of decision models from a decision-theoretic perspective. The techniques described allow us to evaluate various configurations of compiled knowledge given the nature of evidential…

Artificial Intelligence · Computer Science 2013-04-08 David Heckerman , John S. Breese , Eric J. Horvitz

Computational modeling is crucial for understanding and analyzing complex systems. In biology, model creation is a human dependent task that requires reading hundreds of papers and conducting wet lab experiments, which would take days or…

Quantitative Methods · Quantitative Biology 2021-10-22 Yasmine Ahmed , Natasa Miskov-Zivanov

Biomedical research results are being published at a high rate, and with existing search engines, the vast amount of published work is usually easily accessible. However, reproducing published results, either experimental data or…

Molecular Networks · Quantitative Biology 2017-06-19 Kai-Wen Liang , Qinsi Wang , Cheryl Telmer , Divyaa Ravichandran , Peter Spirtes , Natasa Miskov-Zivanov

Complex systems' modeling and simulation are powerful ways to investigate a multitude of natural phenomena providing extended knowledge on their structure and behavior. However, enhanced modeling and simulation require integration of…

Querying new information from knowledge sources, in general, and published literature, in particular, aims to provide precise and quick answers to questions raised about a system under study. In this paper, we present ACCORDION (Automated…

Molecular Networks · Quantitative Biology 2020-05-13 Yasmine Ahmed , Cheryl Telmer , Natasa Miskov-Zivanov

A main challenge of data-driven sciences is how to make maximal use of the progressively expanding databases of experimental datasets in order to keep research cumulative. We introduce the idea of a modeling-based dataset retrieval engine…

Quantitative Methods · Quantitative Biology 2015-06-19 Ali Faisal , Jaakko Peltonen , Elisabeth Georgii , Johan Rung , Samuel Kaski

In this paper, we present an automatic knowledge base construction system from large scale enterprise documents with minimal efforts of human intervention. In the design and deployment of such a knowledge mining system for enterprise, we…

Computation and Language · Computer Science 2021-06-30 Junyi Chai , Yujie He , Homa Hashemi , Bing Li , Daraksha Parveen , Ranganath Kondapally , Wenjin Xu

Models of complicated systems can be represented in different ways - in scientific papers, they are represented using natural language text as well as equations. But to be of real use, they must also be implemented as software, thus making…

Research in the field of automated vehicles, or more generally cognitive cyber-physical systems that operate in the real world, is leading to increasingly complex systems. Among other things, artificial intelligence enables an…

Software Engineering · Computer Science 2025-02-20 Lars Ullrich , Michael Buchholz , Klaus Dietmayer , Knut Graichen

As computer scientists working in bioinformatics/computational biology, we often face the challenge of coming up with an algorithm to answer a biological question. This occurs in many areas, such as variant calling, alignment, and assembly.…

Data Structures and Algorithms · Computer Science 2018-01-04 Paul Medvedev

This review article discusses some common enhanced sampling methods in relation to the process of self-assembly of biomolecules. An introduction to self-assembly and its challenges is covered followed by a brief overview of the methods and…

Soft Condensed Matter · Physics 2025-03-03 Mason Hooten , Het Patel , Yiwei Shao , Rishabh Kumar Singh , Meenakshi Dutt

Scientific models hold the key to better understanding and predicting the behavior of complex systems. The most comprehensive manifestation of a scientific model, including crucial assumptions and parameters that underpin its usability, is…

Software Engineering · Computer Science 2022-03-01 Varish Mulwad , Andrew Crapo , Vijay S. Kumar , James Jobin , Alfredo Gabaldon , Nurali Virani , Sharad Dixit , Narendra Joshi

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

A food composition knowledge base, which stores the essential phyto-, micro-, and macro-nutrients of foods is useful for both research and industrial applications. Although many existing knowledge bases attempt to curate such information,…

Computation and Language · Computer Science 2023-01-27 Jason Youn , Fangzhou Li , Ilias Tagkopoulos

Causal Models are increasingly suggested as a means to reason about the behavior of cyber-physical systems in socio-technical contexts. They allow us to analyze courses of events and reason about possible alternatives. Until now, however,…

Artificial Intelligence · Computer Science 2019-11-13 Severin Kacianka , Amjad Ibrahim , Alexander Pretschner , Alexander Trende , Andreas Lüdtke

Expert diagnostic support systems have been extensively studied. The practical applications of these systems in real-world scenarios have been somewhat limited due to well-understood shortcomings, such as lack of extensibility. More…

Artificial Intelligence · Computer Science 2018-08-15 Murali Ravuri , Anitha Kannan , Geoffrey J. Tso , Xavier Amatriain

Computer-based modelling and simulation have become useful tools to facilitate humans to understand systems in different domains, such as physics, astrophysics, chemistry, biology, economics, engineering and social science. A complex system…

Artificial Intelligence · Computer Science 2021-02-03 Xing Su , Yan Kong , Weihua Li

Consider making a prediction over new test data without any opportunity to learn from a training set of labelled data - instead given access to a set of expert models and their predictions alongside some limited information about the…

Machine Learning · Computer Science 2022-10-12 Alex J. Chan , Mihaela van der Schaar
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