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Parameter identification for mechanistic Ordinary Differential Equation (ODE) models underpins prediction and control in several applications, yet remains a manual and labor-intensive process: datasets are noisy and partial, models can be…

Computational Engineering, Finance, and Science · Computer Science 2025-09-16 Saakaar Bhatnagar

Automated Alzheimer's Disease (AD) screening has predominantly followed the inductive paradigm of pattern recognition, which directly maps the input signal to the outcome label. This paradigm sacrifices construct validity of clinical…

Multiagent Systems · Computer Science 2026-03-19 Jiawen Kang , Kun Li , Dongrui Han , Jinchao Li , Junan Li , Lingwei Meng , Xixin Wu , Helen Meng

We introduce DynAMO, a reinforcement learning paradigm for Dynamic Anticipatory Mesh Optimization. Adaptive mesh refinement is an effective tool for optimizing computational cost and solution accuracy in numerical methods for partial…

Numerical Analysis · Mathematics 2024-03-12 Tarik Dzanic , Ketan Mittal , Dohyun Kim , Jiachen Yang , Socratis Petrides , Brendan Keith , Robert Anderson

Metaheuristic algorithms, widely used for solving complex non-convex and non-differentiable optimization problems, often lack a solid mathematical foundation. In this review, we explore how concepts and methods from kinetic theory can offer…

Optimization and Control · Mathematics 2024-10-15 Giacomo Borghi , Michael Herty , Lorenzo Pareschi

Ensuring the reliability of autonomous driving perception systems requires extensive environment-based testing, yet real-world execution is often impractical. Synthetic datasets have therefore emerged as a promising alternative, offering…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Dingyi Yao , Xinyao Han , Ruibo Ming , Zhihang Song , Lihui Peng , Jianming Hu , Danya Yao , Yi Zhang

The rapid progress in machine learning models has significantly boosted the potential for real-world applications such as autonomous vehicles, disease diagnoses, and recognition of emergencies. The performance of many machine learning…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Sergei Voronin , Abubakar Siddique , Muhammad Iqbal

We investigate the potential of numerical algorithms to decipher the kinetic parameters involved in multi-step chemical reactions. To this end we study a dimerization kinetics of protein as a model system. We follow the dimerization…

Biological Physics · Physics 2014-12-24 Srijeeta Talukder , Shrabani Sen , Ralf Metzler , Suman K Banik , Pinaki Chaudhury

Self-driving laboratories (SDLs) have shown promise to accelerate materials discovery by integrating machine learning with automated experimental platforms. However, errors in the capture of input parameters may corrupt the features used to…

Machine Learning · Computer Science 2026-02-03 Qiuyu Shi , Kangming Li , Yao Fehlis , Runze Zhang , Daniel Persaud , Robert Black , Jason Hattrick-Simpers

Coarse-grained modeling in molecular simulations serves not only to extend accessible time and length scales beyond atomistic limits, but also to reduce high-dimensional chemical data to low-dimensional representations that expose the…

Chemical Physics · Physics 2026-05-19 Michael N. Sakano , Alejandro Strachan

Given the remarkable performance of Large Language Models (LLMs), an important question arises: Can LLMs conduct human-like scientific research and discover new knowledge, and act as an AI scientist? Scientific discovery is an iterative…

Machine Learning · Computer Science 2025-02-24 Tingting Chen , Srinivas Anumasa , Beibei Lin , Vedant Shah , Anirudh Goyal , Dianbo Liu

Automating the development of machine learning algorithms has the potential to unlock new breakthroughs. However, our ability to improve and evaluate algorithm discovery systems has thus far been limited by existing task suites. They suffer…

Accelerated discovery in materials science demands autonomous systems capable of dynamically formulating and solving design problems. In this work, we introduce a novel framework that leverages Bayesian optimization over a problem…

Systems and Control · Electrical Eng. & Systems 2025-02-11 Danial Khatamsaz , Joseph Wagner , Brent Vela , Raymundo Arroyave , Douglas L. Allaire

The identification of dynamic parameters in mechanical systems is important for improving model-based control as well as for performing realistic dynamic simulations. Generally, when identification techniques are applied only a subset of…

Robotics · Computer Science 2026-03-17 Miguel Díaz-Rodríguez , Vicente Mata , Angel Valera , Alvaro Page

Large Language Models (LLMs) suffer from a critical limitation: their knowledge is static and quickly becomes outdated. Retraining these massive models is computationally prohibitive, while existing knowledge editing techniques can be slow…

Computation and Language · Computer Science 2025-12-30 Kabir Khan , Priya Sharma , Arjun Mehta , Neha Gupta , Ravi Narayanan

Advances in generative artificial intelligence are transforming how metal-organic frameworks (MOFs) are designed and discovered. This Perspective introduces the shift from laborious enumeration of MOF candidates to generative approaches…

A common issue when analyzing real-world complex systems is that the interactions between the elements often change over time: this makes it difficult to find optimal models that describe this evolution and that can be estimated from data,…

Statistical Finance · Quantitative Finance 2021-08-04 Carlo Campajola , Domenico Di Gangi , Fabrizio Lillo , Daniele Tantari

Machine learning (ML) has been playing important roles in drug discovery in the past years by providing (pre-)screening tools for prioritising chemical compounds to pass through wet lab experiments. One of the main ML tasks in drug…

Biomolecules · Quantitative Biology 2025-02-25 Alex G. C. de Sá , David B. Ascher

Automatic heuristic design (AHD) has emerged as a promising paradigm for solving NP-hard combinatorial optimization problems (COPs). Recent works show that large language models (LLMs), when integrated into well-designed frameworks (i.e.,…

Artificial Intelligence · Computer Science 2026-05-12 Haoze Lv , Ning Lu , Ziang Zhou , Shengcai Liu

We introduce an autonomous multiagent framework for mechanistic interpretability that automates both explaining and finding internal features in large language models. The system runs two coupled loops: (1) explanation refinement, where an…

Computation and Language · Computer Science 2026-05-05 Arnau Marin-Llobet , Javier Ferrando

The design of alloys is a multi-scale problem that requires a holistic approach that involves retrieving relevant knowledge, applying advanced computational methods, conducting experimental validations, and analyzing the results, a process…

Artificial Intelligence · Computer Science 2024-07-16 Alireza Ghafarollahi , Markus J. Buehler
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