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Neural methods of molecule property prediction require efficient encoding of structure and property relationship to be accurate. Recent work using graph algorithms shows limited generalization in the latent molecule encoding space. We build…

Quantitative Methods · Quantitative Biology 2020-11-26 Prateeth Nayak , Andrew Silberfarb , Ran Chen , Tulay Muezzinoglu , John Byrnes

In this paper, we evaluate the capability of transformer-based language models in making inferences over uncertain text that includes uncertain rules of reasoning. We cover both Pre-trained Language Models (PLMs) and generative Large…

Computation and Language · Computer Science 2024-02-12 Aliakbar Nafar , Kristen Brent Venable , Parisa Kordjamshidi

High-throughput toxicity testing offers a fast and cost-effective way to test large amounts of compounds. A key component for such systems is the automated evaluation via machine learning models. In this paper, we address critical…

Computer Vision and Pattern Recognition · Computer Science 2025-10-10 Thomas Lautenschlager , Nils Friederich , Angelo Jovin Yamachui Sitcheu , Katja Nau , Gaëlle Hayot , Thomas Dickmeis , Ralf Mikut

Machine learning models are poised to make a transformative impact on chemical sciences by dramatically accelerating computational algorithms and amplifying insights available from computational chemistry methods. However, achieving this…

In this thesis, we develop various techniques for working with sets in machine learning. Each input or output is not an image or a sequence, but a set: an unordered collection of multiple objects, each object described by a feature vector.…

Machine Learning · Computer Science 2021-03-09 Yan Zhang

Transferring knowledge from one neural network to another has been shown to be helpful for learning tasks with few training examples. Prevailing fine-tuning methods could potentially contaminate pre-trained features by comparably high…

Machine Learning · Computer Science 2019-07-15 Farshid Varno , Behrouz Haji Soleimani , Marzie Saghayi , Lisa Di Jorio , Stan Matwin

Despite recent advances of data acquisition and algorithms development, machine learning (ML) faces tremendous challenges to being adopted in practical catalyst design, largely due to its limited generalizability and poor explainability.…

Chemical Physics · Physics 2021-11-17 Shih-Han Wang , Hemanth Somarajan Pillai , Siwen Wang , Luke E. K. Achenie , Hongliang Xin

Reaction prediction remains one of the major challenges for organic chemistry, and is a pre-requisite for efficient synthetic planning. It is desirable to develop algorithms that, like humans, "learn" from being exposed to examples of the…

Chemical Physics · Physics 2017-06-01 Jennifer N. Wei , David Duvenaud , Alán Aspuru-Guzik

Improving neural machine translation (NMT) systems with prompting has achieved significant progress in recent years. In this work, we focus on how to integrate multi-knowledge, multiple types of knowledge, into NMT models to enhance the…

Computation and Language · Computer Science 2023-12-11 Ke Wang , Jun Xie , Yuqi Zhang , Yu Zhao

We propose a novel method for hierarchical entity classification that embraces ontological structure at both training and during prediction. At training, our novel multi-level learning-to-rank loss compares positive types against negative…

Computation and Language · Computer Science 2020-04-07 Tongfei Chen , Yunmo Chen , Benjamin Van Durme

In this paper we present a technique to train neural network models on small amounts of data. Current methods for training neural networks on small amounts of rich data typically rely on strategies such as fine-tuning a pre-trained neural…

Machine Learning · Computer Science 2016-11-08 Ark Anderson , Kyle Shaffer , Artem Yankov , Court D. Corley , Nathan O. Hodas

The last decade has seen huge progress in the development of advanced machine learning models; however, those models are powerless unless human users can interpret them. Here we show how the mind's construction of concepts and meaning can…

Machine Learning · Statistics 2016-07-04 Nick Condry

Ontology alignment, a critical process in the Semantic Web for detecting relationships between different ontologies, has traditionally focused on identifying so-called "simple" 1-to-1 relationships through class labels and properties…

Artificial Intelligence · Computer Science 2024-07-24 Reihaneh Amini , Sanaz Saki Norouzi , Pascal Hitzler , Reza Amini

While deep learning has achieved great success in many fields, one common criticism about deep learning is its lack of interpretability. In most cases, the hidden units in a deep neural network do not have a clear semantic meaning or…

Genomics · Quantitative Biology 2019-06-04 Tianle Ma , Aidong Zhang

Pre-trained models are nowadays a fundamental component of machine learning research. In continual learning, they are commonly used to initialize the model before training on the stream of non-stationary data. However, pre-training is…

Machine Learning · Computer Science 2022-05-20 Andrea Cossu , Tinne Tuytelaars , Antonio Carta , Lucia Passaro , Vincenzo Lomonaco , Davide Bacciu

Recently supervised machine learning has been ascending in providing new predictive approaches for chemical, biological and materials sciences applications. In this Perspective we focus on the interplay of machine learning algorithm with…

While deeper and wider neural networks are actively pushing the performance limits of various computer vision and machine learning tasks, they often require large sets of labeled data for effective training and suffer from extremely high…

Computer Vision and Pattern Recognition · Computer Science 2017-10-27 Zhi Zhang , Guanghan Ning , Zhihai He

We investigate the capacity of transformers to learn algorithms involving their context while solely being trained using next token prediction. We set up Markov chains with random transition matrices and we train transformers to predict the…

Machine Learning · Computer Science 2025-08-07 Simon Lepage , Jeremie Mary , David Picard

Finding the main product of a chemical reaction is one of the important problems of organic chemistry. This paper describes a method of applying a neural machine translation model to the prediction of organic chemical reactions. In order to…

Machine Learning · Computer Science 2017-01-02 Juno Nam , Jurae Kim

The task here is to predict the toxicological activity of chemical compounds based on the Tox21 dataset, a benchmark in computational toxicology. After a domain-specific overview of chemical toxicity, we discuss current computational…

Machine Learning · Computer Science 2025-10-28 Eduard Popescu , Adrian Groza , Andreea Cernat
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