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Correlative light-electron microscopy (CLEM) unifies the versatility of light microscopy (LM) with the high resolution of electron microscopy (EM), allowing one to zoom into the complex organization of cells. Most CLEM techniques use…

Far-field super-resolution fluorescence microscopy has been rapidly developed for applications ranging from cell biology to nanomaterials. However, it remains a significant challenge to achieve super-resolution imaging at depth in opaque…

Optics · Physics 2024-05-01 Tengfei Wu , YoonSeok Baek , Fei Xia , Sylvain Gigan , Hilton B. de Aguiar

Transmission electron microscopy is an excellent experimental tool to study the interaction of free electrons with nanoscale light fields. However, up to now, applying electron microscopy to quantum optical investigations was hampered by…

Infrared spectroscopy is the technique of choice for chemical identification of biomolecules through their vibrational fingerprints. However, infrared light interacts poorly with nanometric size molecules. Here, we exploit the unique…

State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this…

The Rayleigh diffraction limit imposes a fundamental restriction on the resolution of direct imaging systems, hindering the identification of incoherent optical sources, such as celestial bodies in astronomy and fluorophores in bioimaging.…

Quantum Physics · Physics 2025-12-12 Danilo Triggiani , Cosmo Lupo

Resolving fine details of astronomical objects provides critical insights into their underlying physical processes. This drives in part the desire to construct ever-larger telescopes and interferometer arrays and to observe at shorter…

Lensless X-ray imaging provides element-specific nanoscale insights into thick samples beyond the reach of conventional light and electron microscopy. Coherent diffraction imaging (CDI) methods, such as ptychographic tomography, can recover…

High-index dielectrics can confine light into nano-scale leading to enhanced nonlinear response. However, increased momentum in these media can deteriorate the overlap between different harmonics which hinders efficient nonlinear…

We show theoretically that coherent light can be completely absorbed in a two-dimensional or three-dimensional metallic nanostructure by matching the frequency and field pattern of an incident wave to that of a localized surface plasmon…

Optics · Physics 2015-05-30 Heeso Noh , Yidong Chong , A. Douglas Stone , Hui Cao

We present a method for training multi-label, massively multi-class image classification models, that is faster and more accurate than supervision via a sigmoid cross-entropy loss (logistic regression). Our method consists in embedding…

Computer Vision and Pattern Recognition · Computer Science 2016-07-20 François Chollet

Automatic prediction of fluorescently labeled organelles from label-free transmitted light input images is an important, yet difficult task. The traditional way to obtain fluorescence images is related to performing biochemical labeling…

Image and Video Processing · Electrical Eng. & Systems 2024-06-04 Marek Wodzinski , Henning Müller

In recent years, a great deal of emphasis has been placed on achieving the diffraction limit with large aperture telescopes. For a well matched focal-plane instrument, the diffraction limit provides the highest possible angular resolution…

Astrophysics · Physics 2009-11-11 J. Bland-Hawthorn , A. Horton

Image recognition techniques heavily rely on abundant labeled data, particularly in medical contexts. Addressing the challenges associated with obtaining labeled data has led to the prominence of self-supervised learning and semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Hao Feng , Yuanzhe Jia , Ruijia Xu , Mukesh Prasad , Ali Anaissi , Ali Braytee

The differentiation between pathological subtypes of non-small cell lung cancer (NSCLC) is an essential step in guiding treatment options and prognosis. However, current clinical practice relies on multi-step staining and labelling…

Quantitative Methods · Quantitative Biology 2026-03-10 Zhenya Zang , David A Dorward , Katherine E Quiohilag , Andrew DJ Wood , James R Hopgood , Ahsan R Akram , Qiang Wang

This paper proposes a non-computational method of counteracting the effect of image degradation introduced by the diffraction phenomenon in lensless microscopy. All the optical images (whether focused by lenses or not) are diffraction…

Optics · Physics 2021-04-08 Sanjeev Kumar , Manjunatha Mahadevappa , Pranab Kumar Dutta

Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies…

Silicon has long been the foundational semiconductor material for a broad range of electronic devices, owing to its numerous advantages: wide natural availability, ease of synthesis in both crystalline and amorphous forms, and relatively…

Materials Science · Physics 2025-06-24 Arturo Ramírez-Porras

Hydrogen detection is of great importance in chemical and energy industries. Optical fiber hydrogen sensors show flexibility and compactness and have the potential for distributed analysis. However, traditional fiber sensors encounter a…

Optics · Physics 2019-05-16 F. Yang , Y. Zhao , Y. Qi , Y. Z. Tan , H. L. Ho , W. Jin

In this paper, we delve into semi-supervised object detection where unlabeled images are leveraged to break through the upper bound of fully-supervised object detection models. Previous semi-supervised methods based on pseudo labels are…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Zhenyu Wang , Yali Li , Ye Guo , Lu Fang , Shengjin Wang
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