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Over the past decade, artificially engineered optical materials and nanostructured thin films have revolutionized the area of photonics by employing novel concepts of metamaterials and metasurfaces where spatially varying structures yield…

The design of a radio frequency quadrupole, an important section of all ion accelerators, and the calculation of its beam dynamics properties can be achieved using the existing computational tools. These programs, originally designed in…

X-Ray image enhancement, along with many other medical image processing applications, requires the segmentation of images into bone, soft tissue, and open beam regions. We apply a machine learning approach to this problem, presenting an…

X-ray imaging is the most widely used medical imaging modality. However, in the common practice, inconsistency in the initial presentation of X-ray images is a common complaint by radiologists. Different patient positions, patient habitus…

Previous studies on event-related functional magnetic resonance imaging experimental designs are primarily based on linear models, in which a known shape of the hemodynamic response function (HRF) is assumed. However, the HRF shape is…

Radiation therapy is one of the most common cancer treatments, and dose optimization and targeting of radiation are crucial since both cancerous and healthy cells are affected. Different mathematical and computational approaches have been…

X-ray radiography is the most readily available imaging modality and has a broad range of applications that spans from diagnosis to intra-operative guidance in cardiac, orthopedics, and trauma procedures. Proper interpretation of the hidden…

The aim of this paper is to propose an optimal control optimization algorithm for reconstructing admittivity distributions (i.e., both conductivity and permittivity) from multi-frequency micro-electrical impedance tomography. A convergent…

We demonstrate a strategy for simulating wide-range X-ray scattering patterns, which spans the small- and wide scattering angles as well as the scattering angles typically used for Pair Distribution Function (PDF) analysis. Such simulated…

Fundus imaging is a critical tool in ophthalmology, with different imaging modalities offering unique advantages. For instance, fundus fluorescein angiography (FFA) can accurately identify eye diseases. However, traditional invasive FFA…

This paper introduces a simple formulation for topology optimization problems ensuring manufacturability by machining. The method distinguishes itself from existing methods by using the advection-diffusion equation with Robin boundary…

We propose a data-efficient workflow to optimize the efficiency of a radial turbine design under a strict budget of high-fidelity computational fluid dynamics simulations. Assuming anisotropic parameter impact, we use a maximum-projection…

This paper presents an application of digital Fourier holography for selective imaging of scatterers with different sizes in turbid media such as biological tissues. A combination of Fourier holography and high-resolution digital recording,…

We describe and demonstrate an optimization-based x-ray image reconstruction framework called Adorym. Our framework provides a generic forward model, allowing one code framework to be used for a wide range of imaging methods ranging from…

Implementation of real-time, continuous, and three-dimensional imaging (4D intervention guidance) would be a quantum leap for minimally-invasive medicine. It allows guidance during interventions by assessing the spatial position of…

Following the recent developement of Fourier ptychographic microscopy (FPM) in the visible range by Zheng et al. (2013), we propose an adaptation for hard x-rays. FPM employs ptychographic reconstruction to merge a series of low-resolution,…

This project is aimed at designing the fast forward projection algorithm and also the backprojection algorithm for cone beam CT imaging systems with circular X-ray source trajectory. The principle of the designs is based on utilizing the…

Radiation therapy is a critical component of cancer treatment. However, the delivery of radiation poses inherent challenges, particularly in minimizing radiation exposure to healthy organs surrounding the tumor site. One significant…

This paper presents a power-efficient mask-constrained ultra-wideband (UWB) waveform design with radio channel effects taken into consideration. Based on a finite impulse response (FIR) filter, we develop a convex optimization model with…

Reconstructing high-quality magnetic resonance images (MRI) from undersampled raw data is of great interest from both technical and clinical point of views. To this date, however, it is still a mathematically and computationally challenging…