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Rapid transduction of sensory stimulation to action is essential for an animal to survive. To this end, most animals use the sub-second excitable and multistable dynamics of a neuromuscular system. Here, studying an animal without neurons…

Biological Physics · Physics 2021-07-08 Matthew S. Bull , Laurel A. Kroo , Manu Prakash

A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps reveal the brain's underlying computations. We investigate how the nematode C. elegans responds to…

Neurons and Cognition · Quantitative Biology 2020-08-18 Mochi Liu , Anuj K Sharma , Joshua W Shaevitz , Andrew M Leifer

Convergence extension, the simultaneous elongation of tissue along one axis while narrowing along a perpendicular axis, occurs during embryonic development. A fundamental process that contributes to shaping the organism, it happens in many…

Soft Condensed Matter · Physics 2023-03-06 Aondoyima Ioratim-Uba , Tanniemola B. Liverpool , Silke Henkes

Eukaryotic cells perform chemotaxis by determining the direction of chemical gradients based on stochastic sensing of concentrations at the cell surface. To examine the efficiency of this process, previous studies have investigated the…

Cell Behavior · Quantitative Biology 2025-02-06 Kento Nakamura , Tetsuya J. Kobayashi

The rheological response under simple shear of an active suspension of Escherichia coli is determined in a large range of shear rates and concentrations. The effective viscosity and the time scales characterizing the bacterial organization…

Existing extremum-seeking control (ESC) approaches typically rely on applying repeated perturbations to input parameters and performing measurements of the corresponding performance output. The required separation between the different…

Systems and Control · Electrical Eng. & Systems 2025-10-06 Wouter Weekers , Alessandro Saccon , Nathan van de Wouw

Particle-in-cell codes are now standard tools for studying ultra-intense laser-plasma interactions. Motivated by direct laser acceleration of electrons in sub-critical plasmas, we examine temporal resolution requirements that must be…

Habituation - a phenomenon in which a dynamical system exhibits a diminishing response to repeated stimulations that eventually recovers when the stimulus is withheld - is universally observed in living systems from animals to unicellular…

Adaptation and Self-Organizing Systems · Physics 2024-07-26 Matthew Smart , Stanislav Y. Shvartsman , Martin Mönnigmann

The classical macroscopic chemotaxis equations have previously been derived from an individual-based description of the tactic response of cells that use a "run-and-tumble" strategy in response to environmental cues. Here we derive…

Cell Behavior · Quantitative Biology 2007-05-23 Radek Erban , Hans G. Othmer

The interactions between diffusing molecules and membrane-bound receptors drive numerous cellular processes. In this work, we develop a spatial model of molecular interactions with membrane receptors by homogenizing the cell membrane and…

Quantitative Methods · Quantitative Biology 2025-01-24 Anil Cengiz , Sean D Lawley

When two stimuli are present in the receptive field of a V4 neuron, the firing rate response is between the weakest and strongest response elicited by each of the stimuli alone (Reynolds et al, 1999, Journal of Neuroscience 19:1736-1753).…

Neurons and Cognition · Quantitative Biology 2007-05-23 Paul H. Tiesinga

We present simulations of evacuation processes using a recently introduced cellular automaton model for pedestrian dynamics. This model applies a bionics approach to describe the interaction between the pedestrians using ideas from…

Statistical Mechanics · Physics 2015-06-24 Ansgar Kirchner , Andreas Schadschneider

Many biological systems can sense periodical variations in a stimulus input and produce well-timed, anticipatory responses after the input is removed. Such systems show memory effects for retaining timing information in the stimulus and…

Neurons and Cognition · Quantitative Biology 2015-09-09 Ying-Jen Yang , Chun-Chung Chen , Pik-Yin Lai , C. K. Chan

Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor…

Cell Behavior · Quantitative Biology 2012-05-09 Koichiro Uriu , Saul Ares , Andrew C. Oates , Luis G. Morelli

Consolidation of synaptic changes in response to neural activity is thought to be fundamental for memory maintenance over a timescale of hours. In experiments, synaptic consolidation can be induced by repeatedly stimulating presynaptic…

Neurons and Cognition · Quantitative Biology 2019-11-14 Chiara Gastaldi , Samuel P. Muscinelli , Wulfram Gerstner

Using Monte Carlo methods, the short-time dynamic scaling behaviour of two-dimensional critical XY systems is investigated. Our results for the XY model show that there exists universal scaling behaviour already in the short-time regime,…

Statistical Mechanics · Physics 2016-08-31 H. J. Luo , M. Schulz , L. Schuelke , S. Trimper , B. Zheng

This paper deals with temporal enzyme distribution in the activation of biochemical pathways. Pathway activation arises when production of a certain biomolecule is required due to changing environmental conditions. Under the premise that…

Quantitative Methods · Quantitative Biology 2008-01-17 Diego Oyarzún , Brian Ingalls , Richard Middleton , Dimitrios Kalamatianos

For group-living animals, reaching consensus to stay cohesive is crucial for their fitness, particularly when collective motion starts and stops. Understanding the decision-making at individual and collective levels upon sudden disturbances…

Biological Physics · Physics 2017-02-08 Sylvain Toulet , Jacques Gautrais , Richard Bon , Fernando Peruani

We experimentally show that the neuron functions as a precise time-integrator, where the accumulated changes in neuronal response latencies, under complex and random stimulation patterns, are solely a function of a global quantity, the…

Neurons and Cognition · Quantitative Biology 2014-04-23 Roni Vardi , Hagar Marmari , Ido Kanter

We systematically investigate the underlying relations among different levels of approximation for simulating electronic de-excitations, with a focus on modeling X-ray emission spectroscopy (XES). Using Fermi's golden rule and explicit…

Materials Science · Physics 2022-08-31 Subhayan Roychoudhury , Leonardo A. Cunha , Martin Head-Gordon , David Prendergast