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This study employs micro-computed tomography (micro-CT) to unravel the geometrical intricacies of the rat urinary bladder wall during various states of ex-vivo filling, contrasting markedly with the commonly held idealizations of uniform…

Medical Physics · Physics 2024-06-03 Fatemeh Azari , Anne M. Robertson , Lori A. Birder

We develop a general analytical and numerical framework for estimating intra- and extra-neurite water fractions and diffusion coefficients, as well as neurite orientational dispersion, in each imaging voxel. By employing a set of rotational…

Biological Physics · Physics 2018-04-10 Dmitry S. Novikov , Jelle Veraart , Ileana O. Jelescu , Els Fieremans

Accurate analysis and modeling of renal functions require a precise segmentation of the renal blood vessels. Micro-CT scans provide image data at higher resolutions, making more small vessels near the renal cortex visible. Although…

Image and Video Processing · Electrical Eng. & Systems 2023-05-29 Peidi Xu , Olga Sosnovtseva , Charlotte Mehlin Sørensen , Kenny Erleben , Sune Darkner

The renal vasculature, acting as a resource distribution network, plays an important role in both the physiology and pathophysiology of the kidney. However, no imaging techniques allow an assessment of the structure and function of the…

Computational Engineering, Finance, and Science · Computer Science 2023-05-11 Peidi Xu , Niels-Henrik Holstein-Rathlou , Stinne Byrholdt Søgaard , Carsten Gundlach , Charlotte Mehlin Sørensen , Kenny Erleben , Olga Sosnovtseva , Sune Darkner

Modelling ultrasound speckle has generated considerable interest for its ability to characterize tissue properties. As speckle is dependent on the underlying tissue architecture, modelling it may aid in tasks like segmentation or disease…

Image and Video Processing · Electrical Eng. & Systems 2022-06-15 Rohit Singla , Ricky Hu , Cailin Ringstrom , Victoria Lessoway , Janice Reid , Christopher Nguan , Robert Rohling

Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…

Quantitative Methods · Quantitative Biology 2020-02-21 Megan J. Chambers , Mitchel J. Colebank , M Umar Qureshi , Rachel Clipp , Mette S. Olufsen

Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made subject-specific modelling of the cardiovascular system a…

Quantitative Methods · Quantitative Biology 2021-01-18 Mitchel J. Colebank , L. Mihaela Paun , M. Umar Qureshi , Naomi Chesler , Dirk Husmeier , Mette S. Olufsen , Laura Ellwein Fix

Kidney branching morphogenesis has been studied extensively, but the mechanism that defines the branch points is still elusive. Here we obtained a 2D movie of kidney branching morphogenesis in culture to test different models of branching…

Tissues and Organs · Quantitative Biology 2013-07-02 Srivathsan Adivarahan , Denis Menshykau , Odysse Michos , Dagmar Iber

Branching in vascular networks and in overall organismic form is one of the most common and ancient features of multicellular plants, fungi, and animals. By combining machine-learning techniques with new theory that relates vascular form to…

The diffusion of minimally invasive, endovascular interventions motivates the development of visualization methods for complex vascular networks. We propose a planar representation of blood vessel trees which preserves the properties that…

Image and Video Processing · Electrical Eng. & Systems 2025-10-23 Guillaume Houry , Tom Boeken , Stéphanie Allassonnière , Jean Feydy

Purpose: To develop a radiomics filtering technique for characterizing spatial-encoded regional pulmonary ventilation information on lung CT. Methods: The lung volume was segmented on 46 CT images, and a 3D sliding window kernel was…

Medical Physics · Physics 2023-01-11 Zhenyu Yang , Kyle J Lafata , Xinru Chen , James Bowsher , Yushi Chang , Chunhao Wang , Fang-Fang Yin

We present a pulmonary vessel segmentation algorithm, which is fast, fully automatic and robust. It uses a coarse segmentation of the airway tree and a left and right lung labeled volume to restrict a vessel enhancement filter, based on an…

Computer Vision and Pattern Recognition · Computer Science 2013-04-29 M. Helmberger , M. Urschler , M. Pienn , Z. Balint , A. Olschewski , H. Bischof

Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microcapillaries. Microvascular bifurcations have a significant influence on the distribution of the blood cells and blood flow behavior. This paper…

Biological Physics · Physics 2016-02-24 Tong Wang , Uwitije Rongin , Zhongwen Xing

We investigate the margination of microparticles/platelets in blood flow through complex geometries typical for in vivo vessel networks: a vessel confluence and a bifurcation. Using 3D Lattice-Boltzmann simulations, we confirm that behind…

Biological Physics · Physics 2018-08-15 C. Bächer , A. Kihm , L. Schrack , L. Kaestner , M. W. Laschke , C. Wagner , S. Gekle

Accurate segmentation of cerebral vasculature and a quantitative assessment of cerebrovascular morphology is critical to various diagnostic and therapeutic purposes and is pertinent to studying brain health and disease. However, this is…

Quantitative Methods · Quantitative Biology 2020-02-27 Aditi Deshpande , Nima Jamilpour , Bin Jiang , Chelsea Kidwell , Max Wintermark , Kaveh Laksari

Vascular remodelling is inherent to the pathogenesis of many diseases including cancer, neurodegeneration, fibrosis, hypertension, and diabetes. In this paper, a new susceptibility-contrast based MRI approach is established to analyse…

Microvessels -blood vessels with diameter less than 200 microns- form large, intricate networks organized into arterioles, capillaries and venules. In these networks, the distribution of flow and pressure drop is a highly interlaced…

Tissues and Organs · Quantitative Biology 2017-08-02 Paola Causin , Francesca Malgaroli

The inherent characteristics of lung tissues, which are independent of breathing manoeuvre, may provide fundamental information on lung function. This paper attempted to study function-correlated lung textures and their spatial distribution…

Medical Physics · Physics 2024-03-28 Yu-Hua Huang , Xinzhi Teng , Jiang Zhang , Zhi Chen , Zongrui Ma , Ge Ren , Feng-Ming , Kong , Jing Cai

Scientists have long sought to understand how vascular networks supply blood and oxygen to cells throughout the body. Recent work focuses on principles that constrain how vessel size changes through branching generations from the aorta to…

Tissues and Organs · Quantitative Biology 2015-09-10 Mitchell G Newberry , Daniel B Ennis , Van M Savage

Sarcoidosis is a rare, multi-systemic, inflammatory disease, primarily affecting the lungs. High-resolution computed tomography (CT) scans are used to clinically characterize pulmonary sarcoidosis. In the medical imaging field, there is…

Medical Physics · Physics 2018-06-28 Sarah M. Ryan , Tasha Fingerlin , Nabeel Hamzeh , Lisa Maier , Nichole Carlson
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