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The paper deals with modeling the liver perfusion intended to improve quantitative analysis of the tissue scans provided by the contrast-enhanced computed tomography (CT). For this purpose, we developed a model of dynamic transport of the…

Computational Engineering, Finance, and Science · Computer Science 2018-08-01 Eduard Rohan , Vladimír Lukeš , Alena Jonášová

The UK Biobank is collecting extensive data on health-related characteristics of over half a million volunteers. The biological samples of blood and urine can provide valuable insight on kidney function, with important links to…

Image and Video Processing · Electrical Eng. & Systems 2020-06-15 Taro Langner , Andreas Östling , Lukas Maldonis , Albin Karlsson , Daniel Olmo , Dag Lindgren , Andreas Wallin , Lowe Lundin , Robin Strand , Håkan Ahlström , Joel Kullberg

Computational anatomy allows the quantitative analysis of organs in medical images. However, most analysis is constrained to the millimeter scale because of the limited resolution of clinical computed tomography (CT). X-ray microtomography…

Computer Vision and Pattern Recognition · Computer Science 2017-02-28 Holger R. Roth , Kai Nagara , Hirohisa Oda , Masahiro Oda , Tomoshi Sugiyama , Shota Nakamura , Kensaku Mori

We present a new method for modeling tissue perfusion on the capillary scale. The microvasculature is represented by a network of one-dimensional vessel segments embedded in the extra-vascular space. Vascular and extra-vascular space…

Computational Physics · Physics 2020-03-23 Timo Koch , Martin Schneider , Rainer Helmig , Patrick Jenny

Morphological features of small vessels provide invaluable information regarding underlying tissue, especially in cancerous tumors. This paper introduces methods for obtaining quantitative morphological features from microvasculature images…

Medical Physics · Physics 2018-12-11 Siavash Ghavami , Mahdi Bayat , Mostafa Fatemi , Azra Alizad

We present a fully automated method for top-down segmentation of the pulmonary arterial tree in low-dose thoracic CT images. The main basal pulmonary arteries are identified near the lung hilum by searching for candidate vessels adjacent to…

Computer Vision and Pattern Recognition · Computer Science 2011-06-28 Jeremiah Wala , Sergei Fotin , Jaesung Lee , Artit Jirapatnakul , Alberto Biancardi , Anthony Reeves

The analysis of biological networks encompasses a wide variety of fields from genomic research of protein-protein interaction networks, to the physiological study of biologically optimized tree-like vascular networks. It is certain that…

Tissues and Organs · Quantitative Biology 2023-01-19 Timothy L. Kline

Segmentation of the bronchovascular bundle within the lung parenchyma is a key step for the proper analysis and planning of many pulmonary diseases. It might also be considered the preprocessing step when the goal is to segment the nodules…

Segmentation of the coronary artery is an important task for the quantitative analysis of coronary computed tomography angiography (CCTA) images and is being stimulated by the field of deep learning. However, the complex structures with…

Image and Video Processing · Electrical Eng. & Systems 2023-05-09 Xiaoyu Yang , Lijian Xu , Simon Yu , Qing Xia , Hongsheng Li , Shaoting Zhang

Application of machine learning techniques enables segmentation of functional tissue units in histology whole-slide images (WSIs). We built a pipeline to apply previously validated segmentation models of kidney structures and extract…

In the context of numerical simulations of the vascular system, local geometric uncertainties have not yet been examined in sufficient detail due to model complexity and the associated large numerical effort. Such uncertainties are related…

The aortic vessel tree is composed of the aorta and its branching arteries, and plays a key role in supplying the whole body with blood. Aortic diseases, like aneurysms or dissections, can lead to an aortic rupture, whose treatment with…

Image and Video Processing · Electrical Eng. & Systems 2023-04-04 Yuan Jin , Antonio Pepe , Jianning Li , Christina Gsaxner , Fen-hua Zhao , Kelsey L. Pomykala , Jens Kleesiek , Alejandro F. Frangi , Jan Egger

Branching architecture characterizes numerous systems, ranging from synthetic (hyper)branched polymers and biomolecules such as lignin, amylopectin, and nucleic acids to tracheal and neuronal networks. Its ubiquity reflects the many…

Soft Condensed Matter · Physics 2025-06-18 Domen Vaupotič , Jules Morand , Luca Tubiana , Anže Božič

Atherosclerotic lesions within carotid and cerebral vessels are likely to influence hemodynamics and manifest into vascular pathologies, including Alzheimers Disease and ischemic stroke. Hemodynamics are influenced by changes in luminal…

Tissues and Organs · Quantitative Biology 2023-03-24 Jennifer Buoncore , Alexis Sobecki , Brian Lee Beatty

The construction of three-dimensional multi-modal tissue maps provides an opportunity to spur interdisciplinary innovations across temporal and spatial scales through information integration. While the preponderance of effort is allocated…

Biological tissue consists of various molecules. Instead of focusing on a particular molecule, we consider the Shannon entropy which is calculated from the abundance of different molecules at each spot in the tissue. The spatial…

Biological Physics · Physics 2023-12-12 Lili Xu , Chi Zhang , Soho Oyama , Manabu Machida , Tomoaki Kahyo , Mitsutoshi Setou

Segmentation of medical images is a challenging task owing to their complexity. A standard segmentation problem within Magnetic Resonance Imaging (MRI) is the task of labeling voxels according to their tissue type. Image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2013-04-02 G. Geethu Lakshmi

Recent advancements in Artificial Intelligence (AI) have significantly influenced the field of Cardiovascular Disease (CVD) analysis, particularly in image-based diagnostics. Our paper presents an extensive review of AI applications in…

Image and Video Processing · Electrical Eng. & Systems 2025-12-12 Xin Wang , Mingcheng Hu , Connie W. Tsao , Hongtu Zhu

Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies…

We propose a novel approach to generate samples from the conditional distribution of patient-specific cardiovascular models given a clinically aquired image volume. A convolutional neural network architecture with dropout layers is first…

Quantitative Methods · Quantitative Biology 2021-09-01 Gabriel Maher , Casey Fleeter , Daniele Schiavazzi , Alison Marsden