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Since early 2020, the world has been dealing with a raging pandemic outbreak: COVID-19. A year later, vaccines have become accessible, but in limited quantities, so that governments needed to devise a strategy to decide which part of the…

Populations and Evolution · Quantitative Biology 2022-04-13 Sander Tonkens , Paul de Klaver , Mauro Salazar

Finding optimal policies to reduce the morbidity and mortality of the ongoing pandemic is a top public health priority. Using a compartmental model with age structure and vaccination status, we examined the effect of age specific scheduling…

Populations and Evolution · Quantitative Biology 2012-02-29 Diána Knipl , Gergely Röst

How to strategically allocate the available vaccines is a crucial issue for pandemic control. In this work, we propose a mathematical framework for optimal stabilizing vaccine allocation, where our goal is to send the infections to zero as…

Optimization and Control · Mathematics 2021-09-13 Qianqian Ma , Yang-Yu Liu , Alex Olshevsky

In a world being hit by waves of COVID-19, vaccination is a light on the horizon. However, the roll-out of vaccination strategies and their influence on the pandemic are still open problems. In order to compare the effect of various…

Physics and Society · Physics 2021-04-23 N. L. Barreiro , C. I. Ventura , T. Govezensky , M. Núñez , P. G. Bolcatto , R. A. Barrio

The limited availability of COVID-19 vaccines has prompted extensive research on optimal vaccination strategies. Previous studies have considered various non-pharmaceutical interventions, vaccine efficacy, and distribution strategies. In…

Populations and Evolution · Quantitative Biology 2025-02-27 Iker Atienza-Diez , Gabriel Rodriguez-Maroto , Saúl Ares , Susanna Manrubia

We evaluate the efficiency of various heuristic strategies for allocating vaccines against COVID-19 and compare them to strategies found using optimal control theory. Our approach is based on a mathematical model which tracks the spread of…

Populations and Evolution · Quantitative Biology 2022-05-04 Jeta Molla , Alejandro Ponce de León Chávez , Takayuki Hiraoka , Tapio Ala-Nissila , Mikko Kivelä , Lasse Leskelä

Massive vaccination against pandemics such as Coronavirus SARS-CoV-2 presents several complexities. The criteria to assess public health policies are fundamental to distribute vaccines in an effective way in order to avoid as many…

Optimization and Control · Mathematics 2023-12-01 José Luis Sainz-Pardo , José Valero

The optimal allocation of vaccines to population subgroups over time is a challenging health care management problem. In the context of a pandemic, the interaction between vaccination policies adopted by multiple agents and the cooperation…

Optimization and Control · Mathematics 2021-09-22 David Rey , Ahmed W Hammad , Meead Saberi

One long-standing question in epidemiological research is how best to allocate limited amounts of vaccine or similar preventative measures in order to minimize the severity of an epidemic. Much of the literature on the problem of vaccine…

Social and Information Networks · Computer Science 2014-12-02 Krzysztof Drewniak , Joseph Helsing , Armin R. Mikler

During the Covid-19 pandemic a key role is played by vaccination to combat the virus. There are many possible policies for prioritizing vaccines, and different criteria for optimization: minimize death, time to herd immunity, functioning of…

Populations and Evolution · Quantitative Biology 2022-03-18 Qi Luo , Ryan Weightman , Sean T. McQuade , Mateo Diaz , Emmanuel Trélat , William Barbour , Dan Work , Samitha Samaranayake , Benedetto Piccoli

The aftermath of the Covid-19 pandemic saw more severe outcomes for racial minority groups and economically-deprived communities. Such disparities can be explained by several factors, including unequal access to healthcare, as well as the…

Computers and Society · Computer Science 2024-03-12 Nicola Neophytou , Afaf Taïk , Golnoosh Farnadi

To mitigate the pandemic stemming from COVID-19, numerous nations have initiated extensive vaccination campaigns for their citizens since late 2020. While affluent countries have predominantly received vaccine allocations, fewer doses have…

Physics and Society · Physics 2024-04-01 Hsin-Ju Chou , Jing-Yuan Ko , Sung-Po Chao

As observed during the COVID-19 pandemic, high-income countries, such as the U.S., may exhibit vaccine nationalism during a pandemic: stockpiling doses of vaccine for their own citizens and being reluctant to distribute doses of the vaccine…

Populations and Evolution · Quantitative Biology 2024-08-21 Abraham Holleran , Susan E. Martonosi , Michael Veatch

We study an optimal control problem where the objective is to find the best vaccine allocation during an epidemic outbreak. The epidemic dynamics is described by an age-structured SIR model with nonlocal interactions. Both the infection and…

Optimization and Control · Mathematics 2026-05-19 Luís Almeida , Romain Ducasse , Elisa Paparelli

Motivated by COVID-19 vaccine allocation, where vulnerable subpopulations are simultaneously more impacted in terms of health and more disadvantaged in terms of access to the vaccine, we formalize and study the problem of resource…

Artificial Intelligence · Computer Science 2024-02-02 Kenya Andrews , Mesrob Ohannessian , Tanya Berger-Wolf

In more than two years since the COVID-19 virus was first detected in China, hundreds of millions of individuals have been infected, and millions have died. Aside from the immediate need for medical solutions (such as vaccines and…

Populations and Evolution · Quantitative Biology 2022-05-17 Hilla De-Leon , Francesco Pederiva

The COVID-19 pandemic highlighted significant challenges in the allocation of vital healthcare resources. Existing epidemiological models, specifically compartmental models, aimed to predict the spread of the COVID-19 virus and its impact…

Physics and Society · Physics 2024-03-14 Hieu Bui , Sandra Eksioglu , Ruben Proano

Optimization of vaccine allocations among different segments of a heterogeneous population is important for enhancing the effectiveness of vaccination campaigns in reducing the burden of epidemics. Intuitively, it would seem that…

Quantitative Methods · Quantitative Biology 2022-12-01 Nir Gavish , Guy Katriel

The threat of avian influenza and the 2004-2005 influenza vaccine supply shortage in the United States has sparked a debate about optimal vaccination strategies to reduce the burden of morbidity and mortality caused by the influenza virus.…

Populations and Evolution · Quantitative Biology 2010-02-10 Shweta Bansal , Babak Pourbohloul , Lauren Ancel Meyers

Balancing social utility and equity in distributing limited vaccines represents a critical policy concern for protecting against the prolonged COVID-19 pandemic. What is the nature of the trade-off between maximizing collective welfare and…

Computers and Society · Computer Science 2021-11-15 Lin Chen , Fengli Xu , Zhenyu Han , Kun Tang , Pan Hui , James Evans , Yong Li
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