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Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

How will my face look when I get older? Or, for a more challenging question: How will my brain look when I get older? To answer this question one must devise (and learn from data) a multivariate auto-regressive function which given an image…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Tian Xia , Agisilaos Chartsias , Chengjia Wang , Sotirios A. Tsaftaris

In this work, we present a novel approach for solving stochastic shape optimization problems. Our method is the extension of the classical stochastic gradient method to infinite-dimensional shape manifolds. We prove convergence of the…

Optimization and Control · Mathematics 2020-11-03 Caroline Geiersbach , Estefania Loayza-Romero , Kathrin Welker

Statistical shape modeling (SSM) characterizes anatomical variations in a population of shapes generated from medical images. SSM requires consistent shape representation across samples in shape cohort. Establishing this representation…

Computer Vision and Pattern Recognition · Computer Science 2022-03-17 Riddhish Bhalodia , Shireen Elhabian , Jadie Adams , Wenzheng Tao , Ladislav Kavan , Ross Whitaker

We propose a novel machine learning strategy for studying neuroanatomical shape variation. Our model works with volumetric binary segmentation images, and requires no pre-processing such as the extraction of surface points or a mesh. The…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Evan M. Yu , Mert R. Sabuncu

This article presents a new mathematical framework to perform statistical analysis on time-indexed sequences of 2D or 3D shapes. At the core of this statistical analysis is the task of time interpolation of such data. Current models in use…

Optimization and Control · Mathematics 2010-03-23 Alain Trouvé , François-Xavier Vialard

Shape completion, i.e., predicting the complete geometry of an object from a partial observation, is highly relevant for several downstream tasks, most notably robotic manipulation. When basing planning or prediction of real grasps on…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Matthias Humt , Dominik Winkelbauer , Ulrich Hillenbrand

Statistical shape models (SSMs) are an established way to represent the anatomy of a population with various clinically relevant applications. However, they typically require domain expertise, and labor-intensive landmark annotations to…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Lennart Bastian , Alexander Baumann , Emily Hoppe , Vincent Bürgin , Ha Young Kim , Mahdi Saleh , Benjamin Busam , Nassir Navab

In order to find effective treatments for Alzheimer's disease (AD), we need to identify subjects at risk of AD as early as possible. To this end, recently developed disease progression models can be used to perform early diagnosis, as well…

Quantitative Methods · Quantitative Biology 2020-03-11 Razvan V. Marinescu

We propose a novel framework for comparing 3D human shapes under the change of shape and pose. This problem is challenging since 3D human shapes vary significantly across subjects and body postures. We solve this problem by using a…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Emery Pierson , Mohamed Daoudi , Alice-Barbara Tumpach

Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder with substantial heterogeneity in progression and treatment response. Despite recent therapeutic advances, predictive models capable of accurately forecasting…

Machine Learning · Computer Science 2025-07-23 Jindong Wang , Yutong Mao , Xiao Liu , Wenrui Hao

This paper represents a groundbreaking advancement in Parkinson disease (PD) research by employing a novel machine learning framework to categorize PD into distinct subtypes and predict its progression. Utilizing a comprehensive dataset…

Machine Learning · Computer Science 2024-06-12 Ashwin Ram

Developing successful artificial intelligence systems in practice depends on both robust deep learning models and large, high-quality data. However, acquiring and labeling data can be prohibitively expensive and time-consuming in many…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Saba Dadsetan , Mohsen Hejrati , Shandong Wu , Somaye Hashemifar

Biomechanical modeling of tissue deformation can be used to simulate different scenarios of longitudinal brain evolution. In this work,we present a deep learning framework for hyper-elastic strain modelling of brain atrophy, during healthy…

Neurons and Cognition · Quantitative Biology 2021-08-19 Mariana Da Silva , Carole H. Sudre , Kara Garcia , Cher Bass , M. Jorge Cardoso , Emma C. Robinson

Pattern recognition methods using neuroimaging data for the diagnosis of Alzheimer's disease have been the subject of extensive research in recent years. In this paper, we use deep learning methods, and in particular sparse autoencoders and…

Computer Vision and Pattern Recognition · Computer Science 2015-02-10 Adrien Payan , Giovanni Montana

Statistical shape modeling aims at capturing shape variations of an anatomical structure that occur within a given population. Shape models are employed in many tasks, such as shape reconstruction and image segmentation, but also shape…

Computer Vision and Pattern Recognition · Computer Science 2022-09-16 David Lüdke , Tamaz Amiranashvili , Felix Ambellan , Ivan Ezhov , Bjoern Menze , Stefan Zachow

Alzheimer's disease is a debilitating disorder marked by a decline in cognitive function. Timely identification of the disease is essential for the development of personalized treatment strategies that aim to mitigate its progression. The…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Xin Hong , Kaifeng Huang

Left atrium shape has been shown to be an independent predictor of recurrence after atrial fibrillation (AF) ablation. Shape-based representation is imperative to such an estimation process, where correspondence-based representation offers…

Alzheimer's disease is a progressive form of dementia that results in problems with memory, thinking, and behavior. It often starts with abnormal aggregation and deposition of beta amyloid and tau, followed by neuronal damage such as…

Applications · Statistics 2022-06-03 Dengdeng Yu , Linbo Wang , Dehan Kong , Hongtu Zhu

Statistical shape modeling (SSM) enables population-based quantitative analysis of anatomical shapes, informing clinical diagnosis. Deep learning approaches predict correspondence-based SSM directly from unsegmented 3D images but require…

Computer Vision and Pattern Recognition · Computer Science 2023-07-21 Jadie Adams , Shireen Elhabian
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