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Scientific modeling and engineering applications rely heavily on parameter estimation methods to fit physical models and calibrate numerical simulations using real-world measurements. In the absence of analytic statistical models with…

Machine Learning · Computer Science 2024-09-30 Ruoxi Jiang , Peter Y. Lu , Rebecca Willett

Single-molecule experiments are a unique tool to characterize the structural dynamics of biomolecules. However, reconstructing molecular details from noisy single-molecule data is challenging. Simulation-based inference (SBI) integrates…

Chemical Physics · Physics 2024-10-22 Lars Dingeldein , Pilar Cossio , Roberto Covino

Current ground-based cosmological surveys, such as the Dark Energy Survey (DES), are predicted to discover thousands of galaxy-scale strong lenses, while future surveys, such as the Vera Rubin Observatory Legacy Survey of Space and Time…

Instrumentation and Methods for Astrophysics · Physics 2022-11-14 Jason Poh , Ashwin Samudre , Aleksandra Ćiprijanović , Brian Nord , Gourav Khullar , Dimitrios Tanoglidis , Joshua A. Frieman

Strong gravitational lenses are a singular probe of the universe's small-scale structure $\unicode{x2013}$ they are sensitive to the gravitational effects of low-mass $(<10^{10} M_\odot)$ halos even without a luminous counterpart. Recent…

Cosmology and Nongalactic Astrophysics · Physics 2024-04-24 Sebastian Wagner-Carena , Jaehoon Lee , Jeffrey Pennington , Jelle Aalbers , Simon Birrer , Risa H. Wechsler

Bayesian inference represents a principled way to incorporate Earth structure uncertainty in full-waveform moment tensor inversions, but traditional approaches generally require significant approximations that risk biasing the resulting…

Geophysics · Physics 2026-03-20 A. A. Saoulis , T. -S. Pham , A. M. G. Ferreira

Simulation-based Bayesian inference (SBI) methods are widely used for parameter estimation in complex models where evaluating the likelihood is challenging but generating simulations is relatively straightforward. However, these methods…

Building on the recent trend of new deep generative models known as Normalizing Flows (NF), simulation-based inference (SBI) algorithms can now efficiently accommodate arbitrary complex and high-dimensional data distributions. The…

Machine Learning · Statistics 2022-11-28 Julia Linhart , Alexandre Gramfort , Pedro L. C. Rodrigues

We present $\texttt{SBi3PCF}$, a simulation-based inference (SBI) framework for analysing a higher-order weak lensing statistic, the integrated 3-point correlation function (i3PCF). Our approach forward-models the cosmic shear field using…

Cosmology and Nongalactic Astrophysics · Physics 2025-10-27 David Gebauer , Anik Halder , Stella Seitz , Dhayaa Anbajagane

We present GalSBI, a phenomenological model of the galaxy population for cosmological applications using simulation-based inference. The model is based on analytical parametrizations of galaxy luminosity functions, morphologies and spectral…

Cosmology and Nongalactic Astrophysics · Physics 2025-06-09 Silvan Fischbacher , Tomasz Kacprzak , Luca Tortorelli , Beatrice Moser , Alexandre Refregier , Patrick Gebhardt , Daniel Gruen

Simulation-Based Inference (SBI) deals with statistical inference in problems where the data are generated from a system that is described by a complex stochastic simulator. The challenge for inference in these problems is that the…

Computation · Statistics 2025-04-17 David Refaeli , Mira Marcus-Kalish , David M. Steinberg

In many cosmological inference problems, the likelihood (the probability of the observed data as a function of the unknown parameters) is unknown or intractable. This necessitates approximations and assumptions, which can lead to incorrect…

Cosmology and Nongalactic Astrophysics · Physics 2020-12-02 Niall Jeffrey , Justin Alsing , François Lanusse

Identifying the parameters of a non-linear model that best explain observed data is a core task across scientific fields. When such models rely on complex simulators, evaluating the likelihood is typically intractable, making traditional…

Comparison of appropriate models to describe observational data is a fundamental task of science. The Bayesian model evidence, or marginal likelihood, is a computationally challenging, yet crucial, quantity to estimate to perform Bayesian…

Cosmology and Nongalactic Astrophysics · Physics 2023-11-10 A. Spurio Mancini , M. M. Docherty , M. A. Price , J. D. McEwen

Simulation-based inference (SBI) provides a powerful framework for inferring posterior distributions of stochastic simulators in a wide range of domains. In many settings, however, the posterior distribution is not the end goal itself --…

Machine Learning · Computer Science 2023-12-19 Mila Gorecki , Jakob H. Macke , Michael Deistler

We present cosmological constraints from weak lensing with the Subaru Hyper Suprime-Cam (HSC) first-year (Y1) data, using a simulation-based inference (SBI) method. % We explore the performance of a set of higher-order statistics (HOS)…

This paper performs the first cosmological parameter analysis of the KiDS-1000 data with second- and third-order shear statistics. This work builds on a series of papers that describe the roadmap to third-order shear statistics. We derive…

Cosmological probes pose an inverse problem where the measurement result is obtained through observations, and the objective is to infer values of model parameters which characterize the underlying physical system -- our Universe. Modern…

Instrumentation and Methods for Astrophysics · Physics 2019-05-21 Timur Takhtaganov , Zarija Lukic , Juliane Mueller , Dmitriy Morozov

We present Sequential Neural Variational Inference (SNVI), an approach to perform Bayesian inference in models with intractable likelihoods. SNVI combines likelihood-estimation (or likelihood-ratio-estimation) with variational inference to…

Machine Learning · Statistics 2022-10-20 Manuel Glöckler , Michael Deistler , Jakob H. Macke

Bayesian optimal experimental design (BOED) seeks to maximize the expected information gain (EIG) of experiments. This requires a likelihood estimate, which in many settings is intractable. Simulation-based inference (SBI) provides powerful…

Machine Learning · Computer Science 2026-02-09 Samuel Klein , Willie Neiswanger , Daniel Ratner , Michael Kagan , Sean Gasiorowski

Because many of our X-ray telescopes are optimized towards observing faint sources, observations of bright sources like X-ray binaries in outburst are often affected by instrumental biases. These effects include dead time and photon…

Instrumentation and Methods for Astrophysics · Physics 2021-12-22 D. Huppenkothen , M. Bachetti
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