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Recent efforts in neuroscience research seek to obtain detailed anatomical neuronal wiring maps as well as information on how neurons in these networks engage in dynamic activities. Although the entire connectivity map of the nervous system…

Neurons and Cognition · Quantitative Biology 2014-06-09 Tina Schrödel , Robert Prevedel , Karin Aumayr , Manuel Zimmer , Alipasha Vaziri

Understanding the dynamical behavior of complex systems from their underlying network architectures is a long-standing question in complexity theory. Therefore, many metrics have been devised to extract network features like motifs,…

Neurons and Cognition · Quantitative Biology 2024-09-05 Bryant Avila , Pedro Augusto , David Phillips , Tommaso Gili , Manuel Zimmer , Hernán A. Makse

The detection of cell shape changes in 3D time-lapse images of complex tissues is an important task. However, it is a challenging and tedious task to establish a comprehensive dataset to improve the performance of deep learning models. In…

Image and Video Processing · Electrical Eng. & Systems 2019-06-04 Dali Wang , Zheng Lu , Zhirong Bao

Networks are a fundamental tool for understanding and modeling complex systems in physics, biology, neuroscience, engineering, and social science. Many networks are known to exhibit rich, lower-order connectivity patterns that can be…

Social and Information Networks · Computer Science 2018-01-08 Austin R. Benson , David F. Gleich , Jure Leskovec

{\it Caenorhabditis elegans} nematode worms are the only animals with the known detailed neural connectivity diagram, well characterized genomics, and relatively simple quantifiable behavioral output. With this in mind, many researchers…

Neurons and Cognition · Quantitative Biology 2019-10-17 Jan Karbowski

Higher order networks are able to characterize data as different as functional brain networks, protein interaction networks and social networks beyond the framework of pairwise interactions. Most notably higher order networks include…

Disordered Systems and Neural Networks · Physics 2018-11-26 Daan Mulder , Ginestra Bianconi

Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve…

Neurons and Cognition · Quantitative Biology 2016-12-21 Ann Sizemore , Chad Giusti , Ari Kahn , Richard F. Betzel , Danielle S. Bassett

Given the inner complexity of the human nervous system, insight into the dynamics of brain activity can be gained from understanding smaller and simpler organisms, such as the nematode C. Elegans. The behavioural and structural biology of…

Neurons and Cognition · Quantitative Biology 2021-07-15 Gonçalo Mestre , Ruxandra Barbulescu , Arlindo L. Oliveira , L. Miguel Silveira

We develop an artificial neural circuit for contour tracking and navigation inspired by the chemotaxis of the nematode Caenorhabditis elegans. In order to harness the computational advantages spiking neural networks promise over their…

Neural and Evolutionary Computing · Computer Science 2014-10-30 Shibani Santurkar , Bipin Rajendran

Matrices are two-dimensional data structures allowing one to conceptually organize information. For example, adjacency matrices are useful to store the links of a network; correlation matrices are simple ways to arrange gene co-expression…

Disordered Systems and Neural Networks · Physics 2022-09-29 Flaviano Morone

Advanced volumetric imaging methods and genetically encoded activity indicators have permitted a comprehensive characterization of whole brain activity at single neuron resolution in \textit{Caenorhabditis elegans}. The constant motion and…

Quantitative Methods · Quantitative Biology 2022-10-12 Yuxiang Wu , Shang Wu , Xin Wang , Chengtian Lang , Quanshi Zhang , Quan Wen , Tianqi Xu

Molecular networks act as the backbone of cellular activities, providing an {excellent} opportunity to understand the developmental changes in an organism. While network data usually constitute only stationary network graphs, constructing…

Molecular Networks · Quantitative Biology 2016-02-29 Pramod Shinde , Sarika Jalan

A central problem of neuroscience involves uncovering the principles governing the organization of nervous systems which ensure robustness in brain development. The nematode Caenorhabditis elegans provides us with a model organism for…

Neurons and Cognition · Quantitative Biology 2020-07-01 Anand Pathak , Nivedita Chatterjee , Sitabhra Sinha

The neural connectome of the nematode Caenorhabditis elegans has been completely mapped, yet in spite of being one of the smallest connectomes (302 neurons), the design principles that explain how the connectome structure determines its…

Disordered Systems and Neural Networks · Physics 2020-01-08 Flaviano Morone , Hernan A. Makse

In large neuronal networks, it is believed that functions emerge through the collective behavior of many interconnected neurons. Recently, the development of experimental techniques that allow simultaneous recording of calcium concentration…

Biological Physics · Physics 2019-06-05 Xiaowen Chen , Francesco Randi , Andrew M. Leifer , William Bialek

We investigate the adaptation and performance of modularity-based algorithms, designed in the scope of complex networks, to analyze the mesoscopic structure of correlation matrices. Using a multi-resolution analysis we are able to describe…

Data Analysis, Statistics and Probability · Physics 2011-03-31 Clara Granell , Sergio Gomez , Alex Arenas

We exploit flow propagation on the directed neuronal network of the nematode Caenorhabditis elegans to reveal dynamically relevant features of its connectome. We find flow-based groupings of neurons at different levels of granularity, which…

Neurons and Cognition · Quantitative Biology 2016-08-09 Karol A. Bacik , Michael T. Schaub , Mariano Beguerisse-Díaz , Yazan N. Billeh , Mauricio Barahona

We investigate joint graph inference for the chemical and electrical connectomes of the \textit{Caenorhabditis elegans} roundworm. The \textit{C.elegans} connectomes consist of $253$ non-isolated neurons with known functional attributes,…

Applications · Statistics 2015-08-06 Li Chen , Joshua T. Vogelstein , Vince Lyzinski , Carey E. Priebe

Capturing how the Caenorhabditis elegans connectome structure gives rise to its neuron functionality remains unclear. It is through fiber symmetries found in its neuronal connectivity that synchronization of a group of neurons can be…

Neurons and Cognition · Quantitative Biology 2024-05-07 Bryant Avila , Pedro Augusto , Manuel Zimmer , Matteo Serafino , Hernán A. Makse

Complex networks can often be decomposed into less complex sub-networks whose structures can give hints about the functional organization of the network as a whole. However, these structural motifs can only tell one part of the functional…

Molecular Networks · Quantitative Biology 2015-05-20 Jifeng Qian , Arend Hintze , Christoph Adami