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In recent years, several machine learning approaches have been proposed to predict gene expression and epigenetic signals from the DNA sequence alone. These models are often used to deduce, and, to some extent, assess putative new…

Genomics · Quantitative Biology 2023-04-26 Laurent Bréhélin

Deep Neural Network (DNN) has gained unprecedented performance due to its automated feature extraction capability. This high order performance leads to significant incorporation of DNN models in different Internet of Things (IoT)…

Machine Learning · Computer Science 2020-10-09 Rahul Mishra , Hari Prabhat Gupta , Tanima Dutta

A new set of DNA base-nucleic acid codes and their hypercomplex number representation have been introduced for taking the probability of each nucleotide into full account. A new scoring system has been proposed to suit the hypercomplex…

Other Quantitative Biology · Quantitative Biology 2014-03-12 Jian-Jun Shu , Li Shan Ouw

DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

Genomics · Quantitative Biology 2021-01-14 Hasindu Gamaarachchi

Computational complexity is a key limitation of genomic analyses. Thus, over the last 30 years, researchers have proposed numerous fast heuristic methods that provide computational relief. Comparing genomic sequences is one of the most…

In this paper, we study methods for improving the efficiency and privacy of compressed DNA sequence comparison computations, under various querying scenarios. For instance, one scenario involves a querier, Bob, who wants to test if his DNA…

Cryptography and Security · Computer Science 2011-07-20 David Eppstein , Michael T. Goodrich , Pierre Baldi

We consider the problem of storing and retrieving information from synthetic DNA media. The mathematical basis of the problem is the construction and design of sequences that may be discriminated based on their collection of substrings…

Information Theory · Computer Science 2015-02-03 Han Mao Kiah , Gregory J. Puleo , Olgica Milenkovic

With the rapid increase of available digital data, DNA storage is identified as a storage media with high density and capability of long-term preservation, especially for archival storage systems. However, the encoding density (i.e., how…

Emerging Technologies · Computer Science 2021-08-26 Bingzhe Li , Li Ou , David Du

Neural compression is the application of neural networks and other machine learning methods to data compression. Recent advances in statistical machine learning have opened up new possibilities for data compression, allowing compression…

Machine Learning · Computer Science 2023-08-22 Yibo Yang , Stephan Mandt , Lucas Theis

Genomic sequence analysis plays a crucial role in various scientific and medical domains. Traditional machine-learning approaches often struggle to capture the complex relationships and hierarchical structures of sequence data when working…

Machine Learning · Computer Science 2025-10-02 Sarwan Ali , Haris Mansoor , Murray Patterson

This paper studies two problems that are motivated by the novel recent approach of composite DNA that takes advantage of the DNA synthesis property which generates a huge number of copies for every synthesized strand. Under this paradigm,…

Information Theory · Computer Science 2025-05-15 Tomer Cohen , Eitan Yaakobi

In the field of biological research, it is essential to comprehend the characteristics and functions of molecular sequences. The classification of molecular sequences has seen widespread use of neural network-based techniques. Despite their…

Machine Learning · Computer Science 2024-02-14 Sarwan Ali , Tamkanat E Ali , Prakash Chourasia , Murray Patterson

In this review paper, we delve into the nascent field of molecular data storage, focusing on system implementations and code constructions. We start by providing an overview of basic concepts in synthetic and computational biology.…

Emerging Technologies · Computer Science 2023-10-10 Olgica Milenkovic , Chao Pan

DNA storage technology offers new possibilities for addressing massive data storage due to its high storage density, long-term preservation, low maintenance cost, and compact size. To improve the reliability of stored information, base…

Machine Learning · Computer Science 2024-09-24 Bowen Liu , Jiankun Li

This paper investigates the influence of genotype size on evolutionary algorithms' performance. We consider genotype compression (where genotype is smaller than phenotype) and expansion (genotype is larger than phenotype) and define…

Neural and Evolutionary Computing · Computer Science 2021-05-26 Lucija Planinic , Marko Djurasevic , Luca Mariot , Domagoj Jakobovic , Stjepan Picek , Carlos Coello Coello

The recent advances in deep neural networks (DNNs) make them attractive for embedded systems. However, it can take a long time for DNNs to make an inference on resource-constrained computing devices. Model compression techniques can address…

Machine Learning · Computer Science 2018-10-23 Qing Qin , Jie Ren , Jialong Yu , Ling Gao , Hai Wang , Jie Zheng , Yansong Feng , Jianbin Fang , Zheng Wang

Recent advances in deep learning have made available large, powerful convolutional neural networks (CNN) with state-of-the-art performance in several real-world applications. Unfortunately, these large-sized models have millions of…

Machine Learning · Computer Science 2020-07-17 Giosuè Cataldo Marinò , Gregorio Ghidoli , Marco Frasca , Dario Malchiodi

Despite rapid advancements, machine learning, particularly deep learning, is hindered by the need for large amounts of labeled data to learn meaningful patterns without overfitting and immense demands for computation and storage, which…

Machine Learning · Computer Science 2025-06-30 Xiaobo Zhao , Aaron Hurst , Panagiotis Karras , Daniel E. Lucani

Overparameterized models have proven to be powerful tools for solving various machine learning tasks. However, overparameterization often leads to a substantial increase in computational and memory costs, which in turn requires extensive…

Machine Learning · Computer Science 2024-03-13 Soo Min Kwon , Zekai Zhang , Dogyoon Song , Laura Balzano , Qing Qu

Current techniques in sequencing a genome allow a service provider (e.g. a sequencing company) to have full access to the genome information, and thus the privacy of individuals regarding their lifetime secret is violated. In this paper, we…

Genomics · Quantitative Biology 2018-11-28 Ali Gholami , Mohammad Ali Maddah-Ali , Seyed Abolfazl Motahari
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