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The RefleXion X1 is the first biology-guided radiotherapy (BgRT) system. Its dual 90-degree PET detector collects fewer pair production events compared to a full-ring diagnostic PET system. In the proposed BgRT workflow, a short scan is…
Dynamic total body positron emission tomography (TB-PET) makes it feasible to measure the kinetics of all organs in the body simultaneously which may lead to important applications in multi-organ disease and systems physiology. Since…
Background: A crucial initial processing step for quantitative PET/CT analysis is the segmentation of tumor lesions enabling accurate feature ex-traction, tumor characterization, oncologic staging, and image-based therapy response…
Single Photon Emission Computed Tomography (SPECT) is a non-invasive imaging modality, frequently used in myocardial perfusion imaging. The biggest challenges facing the majority of clinical SPECT systems are low sensitivity, poor…
Enhanced-accuracy ion-range verification in real time shall enable a significant step forward in the use of therapeutic ion beams. Positron-emission tomography (PET) and prompt-gamma imaging (PGI) are two of the most promising and…
One of the most challenges in medical imaging is the lack of data and annotated data. It is proven that classical segmentation methods such as U-NET are useful but still limited due to the lack of annotated data. Using a weakly supervised…
Purpose: Neural network image reconstruction directly from measurement data is a relatively new field of research, that until now has been limited to producing small single-slice images (e.g., 1x128x128). This paper proposes a novel and…
The design, construction, and preliminary testing of a second generation proton CT scanner is presented. All current treatment planning systems at proton therapy centers use X-ray CT as the primary imaging modality for treatment planning to…
The kernel reconstruction is a method that reduces noise in dynamic positron emission tomography (PET) by exploiting spatial correlations in the PET image. Although this method works well for large anatomical regions with relatively slow…
In positron emission tomography (PET), it is indispensable to perform attenuation correction in order to obtain the quantitatively accurate activity map (tracer distribution) in the body. Generally, this is carried out based on the…
Total Body Photography (TBP) is becoming a useful screening tool for patients at high risk for skin cancer. While much progress has been made, existing TBP systems can be further improved for automatic detection and analysis of suspicious…
Passive Gamma Emission Tomography (PGET) has been developed by the International Atomic Energy Agency as a way to directly image the spatial distribution of individual fuel pins in a spent nuclear fuel assembly and so determine potential…
The high cost and low image quality traditionally associated with proton computed tomography (pCT) have prevented it from seeing significant use in clinical settings. A cheap, compact, high-density scintillating glass detector capable of…
Carbon ion therapy have the ability to overcome the limitation of convertional radiotherapy due to its most energy deposition in selective depth, usually called Bragg peak, which results in increased biological effectiness. During carbon…
18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET) imaging usually needs a full-dose radioactive tracer to obtain satisfactory diagnostic results, which raises concerns about the potential health risks of radiation…
Multi-modality Fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) has been routinely used in the assessment of common cancers, such as lung cancer, lymphoma, and melanoma. This is mainly attributed to the…
Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) automatic 3-D registration is implemented and validated for small animal image volumes so that the high-resolution anatomical MRI information can be fused with the low…
We develop and evaluate MlPET, a fast localized machine learning approach for probabilistic PET image analysis addressing the noise-resolution trade-off in conventional reconstructions. MlPET replaces computationally demanding Markov chain…
Deep-learning-based MR-to-CT synthesis can estimate the electron density of tissues, thereby facilitating PET attenuation correction in whole-body PET/MR imaging. However, whole-body MR-to-CT synthesis faces several challenges including the…
Positron Emission Tomography (PET) is an imaging method that can assess physiological function rather than structural disturbances by measuring cerebral perfusion or glucose consumption. However, this imaging technique relies on injection…