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Self-supervised learning has proven to be an effective way to learn representations in domains where annotated labels are scarce, such as medical imaging. A widely adopted framework for this purpose is contrastive learning and it has been…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Hugo Figueiras , Helena Aidos , Nuno Cruz Garcia

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

The scarcity of labeled action data poses a considerable challenge for developing machine learning algorithms for robotic object manipulation. It is expensive and often infeasible for a robot to interact with many objects. Conversely,…

Robotics · Computer Science 2024-12-03 Emily Liu , Michael Noseworthy , Nicholas Roy

Deep learning models are widely used for solving challenging code processing tasks, such as code generation or code summarization. Traditionally, a specific model architecture was carefully built to solve a particular code processing task.…

Software Engineering · Computer Science 2022-11-18 Sergey Troshin , Nadezhda Chirkova

With the widespread deployment of deep learning models, they influence their environment in various ways. The induced distribution shifts can lead to unexpected performance degradation in deployed models. Existing methods to anticipate…

Developing machine learning-based interatomic potentials from ab-initio electronic structure methods remains a challenging task for computational chemistry and materials science. This work studies the capability of transfer learning, in…

Computational Physics · Physics 2023-03-22 Viktor Zaverkin , David Holzmüller , Luca Bonfirraro , Johannes Kästner

Molecular property prediction (e.g., energy) is an essential problem in chemistry and biology. Unfortunately, many supervised learning methods usually suffer from the problem of scarce labeled molecules in the chemical space, where such…

Machine Learning · Computer Science 2020-07-08 Zhongkai Hao , Chengqiang Lu , Zheyuan Hu , Hao Wang , Zhenya Huang , Qi Liu , Enhong Chen , Cheekong Lee

Molecular property prediction, crucial for early drug candidate screening and optimization, has seen advancements with deep learning-based methods. While deep learning-based methods have advanced considerably, they often fall short in fully…

Biomolecules · Quantitative Biology 2024-07-01 Taojie Kuang , Yiming Ren , Zhixiang Ren

We propose that small pretrained foundational generative language models with millions of parameters can be utilized as a general learning framework for sequence-based tasks. Our proposal overcomes the computational resource, skill set, and…

Computation and Language · Computer Science 2024-02-09 Ben Fauber

Predicting molecular properties with data-driven methods has drawn much attention in recent years. Particularly, Graph Neural Networks (GNNs) have demonstrated remarkable success in various molecular generation and prediction tasks. In…

Quantitative Methods · Quantitative Biology 2021-10-19 Zaixi Zhang , Qi Liu , Hao Wang , Chengqiang Lu , Chee-Kong Lee

Finetuning a pretrained model has become a standard approach for training neural networks on novel tasks, resulting in fast convergence and improved performance. In this work, we study an alternative finetuning method, where instead of…

Machine Learning · Computer Science 2023-07-04 Gal Kaplun , Andrey Gurevich , Tal Swisa , Mazor David , Shai Shalev-Shwartz , Eran Malach

Pretrained Graph Neural Networks have been widely adopted for various molecular property prediction tasks. Despite their ability to encode structural and relational features of molecules, traditional fine-tuning of such pretrained GNNs on…

Machine Learning · Computer Science 2024-01-30 Vishal Dey , Xia Ning

Models based on machine learning can enable accurate and fast molecular property predictions, which is of interest in drug discovery and material design. Various supervised machine learning models have demonstrated promising performance,…

Machine Learning · Computer Science 2022-12-15 Jerret Ross , Brian Belgodere , Vijil Chenthamarakshan , Inkit Padhi , Youssef Mroueh , Payel Das

Machine learning (ML) based interatomic potentials have transformed the field of atomistic materials modelling. However, ML potentials depend critically on the quality and quantity of quantum-mechanical reference data with which they are…

Computational Physics · Physics 2023-08-01 John L. A. Gardner , Kathryn T. Baker , Volker L. Deringer

Accurate prediction of energy and forces for 3D molecular systems is one of fundamental challenges at the core of AI for Science applications. Many powerful and data-efficient neural networks predict molecular energies and forces from…

Chemical Physics · Physics 2026-04-23 Ali Mollahosseini , Mohammed Haroon Dupty , Wee Sun Lee

Learning to generalise from limited data is a fundamental challenge for both artificial and biological systems. A common strategy is to extract reusable structure from abundant unlabelled data, enabling efficient adaptation to new tasks…

Machine Learning · Computer Science 2026-05-20 Valentina Njaradi , Clémentine Dominé , Rachel Swanson , Marco Mondelli , Andrew Saxe

This paper challenges the recent paradigm in atomic property prediction that links progress to growing dataset sizes and computational resources. We show that pretraining on a carefully selected task-aligned dataset can match or even…

Machine Learning · Computer Science 2026-02-03 Yasir Ghunaim , Hasan Abed Al Kader Hammoud , Bernard Ghanem

In recent years, pretraining models have made significant advancements in the fields of natural language processing (NLP), computer vision (CV), and life sciences. The significant advancements in NLP and CV are predominantly driven by the…

Machine Learning · Computer Science 2024-07-02 Xiaohong Ji , Zhen Wang , Zhifeng Gao , Hang Zheng , Linfeng Zhang , Guolin Ke , Weinan E

Supervised deep convolutional neural networks (DCNNs) are currently one of the best computational models that can explain how the primate ventral visual stream solves object recognition. However, embodied cognition has not been considered…

Machine Learning · Computer Science 2021-06-21 Maytus Piriyajitakonkij , Sirawaj Itthipuripat , Theerawit Wilaiprasitporn , Nat Dilokthanakul

Neural network models and deep models are one of the leading and state of the art models in machine learning. Most successful deep neural models are the ones with many layers which highly increases their number of parameters. Training such…

Machine Learning · Computer Science 2018-07-17 Soufiane Belharbi