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In most natural sciences there is currently the insight that it is necessary to bridge gaps between different processes which can be observed on different scales. This is especially true in the field of chemical reactions where the…

Molecular Networks · Quantitative Biology 2008-03-03 L. Sbano , M. Kirkilionis

In this paper we propose two new subclasses of Petri nets with resets, for which the reachability and coverability problems become tractable. Namely, we add an acyclicity condition that only applies to the consumptions and productions, not…

Formal Languages and Automata Theory · Computer Science 2023-11-07 Dmitry Chistikov , Wojciech Czerwiński , Piotr Hofman , Filip Mazowiecki , Henry Sinclair-Banks

In this paper, a novel computational technique for finite discrete approximation of continuous dynamical systems suitable for a significant class of biochemical dynamical systems is introduced. The method is parameterized in order to affect…

Systems and Control · Computer Science 2011-09-09 L. Brim , J. Fabriková , S. Dražan , D. Šafránek

We present a data-driven method for computing approximate forward reachable sets using separating kernels in a reproducing kernel Hilbert space. We frame the problem as a support estimation problem, and learn a classifier of the support as…

Optimization and Control · Mathematics 2020-11-20 Adam J. Thorpe , Kendric R. Ortiz , Meeko M. K. Oishi

Gaining insights from realistic dynamical models of biochemical systems can be challenging given their large number of state variables. Model reduction techniques can mitigate this by decreasing complexity by mapping the model onto a…

Computational Engineering, Finance, and Science · Computer Science 2024-11-22 Alexander Leguizamon-Robayo , Antonio Jiménez-Pastor , Micro Tribastone , Max Tschaikowski , Andrea Vandin

This paper studies the problem of controlling complex networks, that is, the joint problem of selecting a set of control nodes and of designing a control input to steer a network to a target state. For this problem (i) we propose a metric…

Systems and Control · Computer Science 2014-03-04 Fabio Pasqualetti , Sandro Zampieri , Francesco Bullo

Restrictions to molecular motion by barriers (membranes) are ubiquitous in biological tissues, porous media and composite materials. A major challenge is to characterize the microstructure of a material or an organism nondestructively using…

Soft Condensed Matter · Physics 2011-03-11 Dmitry S. Novikov , Els Fieremans , Jens H. Jensen , Joseph A. Helpern

Verifying correctness of deep neural networks (DNNs) is challenging. We study a generic reachability problem for feed-forward DNNs which, for a given set of inputs to the network and a Lipschitz-continuous function over its outputs,…

Machine Learning · Computer Science 2018-05-08 Wenjie Ruan , Xiaowei Huang , Marta Kwiatkowska

In this paper, we investigate the problem of controlling probabilistic Boolean control networks (PBCNs) to achieve reachability with maximum probability in the finite time horizon. We address three questions: 1) finding control policies…

Systems and Control · Electrical Eng. & Systems 2023-12-13 Hongyue Fan , Jingjie Ni , Fangfei Li

We introduce a new threshold model of social networks, in which the nodes influenced by their neighbours can adopt one out of several alternatives. We characterize the graphs for which adoption of a product by the whole network is possible…

Social and Information Networks · Computer Science 2015-03-19 Krzysztof R. Apt , Evangelos Markakis

This paper presents an in-reachability based classification of invariant synchrony patterns in Coupled Cell Networks (CCNs). These patterns are encoded through partitions on the set of cells, whose subsets of synchronized cells are called…

Dynamical Systems · Mathematics 2023-10-24 Pedro M Sequeira , João P Hespanha , António P Aguiar

Motivated by applications requiring sparse or nonnegative controls, we investigate reachability properties of linear infinite-dimensional control problems under conic constraints. Relaxing the problem to convex constraints if the initial…

Optimization and Control · Mathematics 2024-05-14 Camille Pouchol , Emmanuel Trélat , Christophe Zhang

Chemical reaction networks are widely used to model stochastic dynamics in chemical kinetics, systems biology and epidemiology. Solving the chemical master equation that governs these systems poses a significant challenge due to the large…

Molecular Networks · Quantitative Biology 2025-12-16 Jiayu Weng , Xinyi Zhu , Jing Liu , Linyuan Lü , Pan Zhang , Ying Tang

Stochastic Processing Networks (SPNs) can be used to model communication networks, manufacturing systems, service systems, etc. We consider a real-time SPN where tasks generate jobs with strict deadlines according to their traffic patterns.…

Networking and Internet Architecture · Computer Science 2012-04-23 I-Hong Hou , Rahul Singh

With the advent of reliable positioning technologies and prevalence of location-based services, it is now feasible to accurately study the propagation of items such as infectious viruses, sensitive information pieces, and malwares through a…

Databases · Computer Science 2012-05-31 Houtan Shirani-Mehr , Farnoush Banaei Kashani , Cyrus Shahabi

Remote Direct Memory Access (RDMA) is a technology that allows direct memory access from the memory of one computer into that of another without involving either one's operating system. This enables high-throughput, low-latency networking,…

Logic in Computer Science · Computer Science 2026-05-12 Parosh Aziz Abdulla , Mohamed Faouzi Atig , Govind Rajanbabu , Stephan Spengler

Suitable reachability conditions can make two different fixed point semantics of a transition system coincide. For instance, the total and partial expected reward semantics on Markov chains (MCs) coincide whenever the MC at hand is almost…

Logic in Computer Science · Computer Science 2025-09-08 Mayuko Kori , Kazuki Watanabe , Jurriaan Rot

In the field of molecular computation based on chemical reaction networks (CRNs), leveraging parallelism to enable coupled mass-action systems (MASs) to retain predefined computational functionality has been a research focus. MASs…

Dynamical Systems · Mathematics 2025-10-16 Renlei Jiang , Chuanhou Gao , Denis Dochain

Petri nets provide accurate analogues to chemical reaction networks, with places representing individual molecules (the resources of the system) and transitions representing chemical reactions which convert educt molecules into product…

Discrete Mathematics · Computer Science 2025-09-03 Addie Jordon , Juri Kolčák , Daniel Merkle

The exploration of pathways and alternative pathways that have a specific function is of interest in numerous chemical contexts. A framework for specifying and searching for pathways has previously been developed, but a focus on which of…

Molecular Networks · Quantitative Biology 2024-12-23 Jakob L. Andersen , Sissel Banke , Rolf Fagerberg , Christoph Flamm , Daniel Merkle , Peter F. Stadler