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Restricted Boltzmann Machines (RBMs) are probabilistic generative models that can be trained by maximum likelihood in principle, but are usually trained by an approximate algorithm called Contrastive Divergence (CD) in practice. In general,…

Upon the discovery of adversarial attacks, robust models have become obligatory for deep learning-based systems. Adversarial training with first-order attacks has been one of the most effective defenses against adversarial perturbations to…

Machine Learning has been applied in a wide range of tasks throughout the last years, ranging from image classification to autonomous driving and natural language processing. Restricted Boltzmann Machine (RBM) has received recent attention…

Intrinsically disordered proteins (IDPs) and multidomain proteins with flexible linkers show a high level of structural heterogeneity and are best described by ensembles consisting of multiple conformations with associated thermodynamic…

In this work, we introduce a new procedure for applying Restricted Boltzmann Machines (RBMs) to missing data inference tasks, based on linearization of the effective energy function governing the distribution of observations. We compare the…

Graph generation generally aims to create new graphs that closely align with a specific graph distribution. Existing works often implicitly capture this distribution through the optimization of generators, potentially overlooking the…

The restricted Boltzmann machine (RBM) is a representative generative model based on the concept of statistical mechanics. In spite of the strong merit of interpretability, unavailability of backpropagation makes it less competitive than…

We consider a special type of Restricted Boltzmann machine (RBM), namely a Gaussian-spherical RBM where the visible units have Gaussian priors while the vector of hidden variables is constrained to stay on an ${\mathbbm L}_2$ sphere. The…

Molecular conformer generation is a fundamental task in computational chemistry. Several machine learning approaches have been developed, but none have outperformed state-of-the-art cheminformatics methods. We propose torsional diffusion, a…

Stochastic neural networks such as Restricted Boltzmann Machines (RBMs) have been successfully used in applications ranging from speech recognition to image classification. Inference and learning in these algorithms use a Markov Chain Monte…

A machine learning model, under the influence of observed or unobserved confounders in the training data, can learn spurious correlations and fail to generalize when deployed. For image classifiers, augmenting a training dataset using…

A goal of unsupervised machine learning is to build representations of complex high-dimensional data, with simple relations to their properties. Such disentangled representations make easier to interpret the significant latent factors of…

Building a good generative model for image has long been an important topic in computer vision and machine learning. Restricted Boltzmann machine (RBM) is one of such models that is simple but powerful. However, its restricted form also has…

Many pairwise additive force fields are in active use for intrinsically disordered proteins (IDPs) and regions (IDRs), some of which modify energetic terms to improve description of IDPs/IDRs, but are largely in disagreement with solution…

Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and many diverging properties. IDPs-and intrinsically disordered regions (IDRs) interspersed between folded domains-are generally characterized as…

The family of f-divergences is ubiquitously applied to generative modeling in order to adapt the distribution of the model to that of the data. Well-definedness of f-divergences, however, requires the distributions of the data and model to…

Boltzmann machines are energy-based models that have been shown to provide an accurate statistical description of domains of evolutionary-related protein and RNA families. They are parametrized in terms of local biases accounting for…

Recent work argues that robust training requires substantially larger datasets than those required for standard classification. On CIFAR-10 and CIFAR-100, this translates into a sizable robust-accuracy gap between models trained solely on…

Many computer vision applications involve modeling complex spatio-temporal patterns in high-dimensional motion data. Recently, restricted Boltzmann machines (RBMs) have been widely used to capture and represent spatial patterns in a single…

This is a tutorial and survey paper on Boltzmann Machine (BM), Restricted Boltzmann Machine (RBM), and Deep Belief Network (DBN). We start with the required background on probabilistic graphical models, Markov random field, Gibbs sampling,…