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Related papers: H&E Stain Normalization using U-Net

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Histopathological evaluation of tissue samples is a key practice in patient diagnosis and drug development, especially in oncology. Historically, Hematoxylin and Eosin (H&E) has been used by pathologists as a gold standard staining.…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Amal Lahiani , Jacob Gildenblat , Irina Klaman , Shadi Albarqouni , Nassir Navab , Eldad Klaiman

Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin and eosin stain (H&E) is one of the principal stains in histology but…

Computer Vision and Pattern Recognition · Computer Science 2019-02-21 Aman Rana , Gregory Yauney , Alarice Lowe , Pratik Shah

Conventional hematoxylin-eosin (H&E) staining is limited to revealing cell morphology and distribution, whereas immunohistochemical (IHC) staining provides precise and specific visualization of protein activation at the molecular level.…

Image and Video Processing · Electrical Eng. & Systems 2024-07-30 Fuqiang Chen , Ranran Zhang , Boyun Zheng , Yiwen Sun , Jiahui He , Wenjian Qin

Chemical staining methods are dependable but require extensive time, expensive chemicals, and raise environmental concerns. These challenges highlight the need for alternative solutions like virtual staining, which accelerates the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-02 Mehdi Ounissi , Ilias Sarbout , Jean-Pierre Hugot , Christine Martinez-Vinson , Dominique Berrebi , Daniel Racoceanu

Hematoxylin and Eosin (H&E) staining is widely regarded as the standard in pathology for diagnosing diseases and tracking tumor recurrence. While H&E staining shows tissue structures, it lacks the ability to reveal specific proteins that…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

Tumor spatial heterogeneity analysis requires precise correlation between Hematoxylin and Eosin H&E morphology and immunohistochemical (IHC) biomarker expression, yet current methods suffer from spatial misalignment in consecutive sections,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Yizhe Yuan , Bingsen Xue , Bangzheng Pu , Chengxiang Wang , Cheng Jin

Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance. Due to this color shift between laboratories, convolutional neural networks (CNNs)…

Computer Vision and Pattern Recognition · Computer Science 2020-04-16 David Tellez , Geert Litjens , Peter Bandi , Wouter Bulten , John-Melle Bokhorst , Francesco Ciompi , Jeroen van der Laak

Network embedding is an effective way to solve the network analytics problems such as node classification, link prediction, etc. It represents network elements using low dimensional vectors such that the graph structural information and…

Social and Information Networks · Computer Science 2019-09-04 Yucheng Lin , Xiaoqing Yang , Zang Li , Jieping Ye

Stains are essential in histopathology to visualize specific tissue characteristics, with Haematoxylin and Eosin (H&E) serving as the clinical standard. However, pathologists frequently utilize a variety of special stains for the diagnosis…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Oskar Thaeter , Christian Grashei , Anette Haas , Elisa Schmoeckel , Han Li , Peter J. Schüffler

Virtual stain transfer leverages computer-assisted technology to transform the histochemical staining patterns of tissue samples into other staining types. However, existing methods often lose detailed pathological information due to the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Haiyan Wei , Hangrui Xu , Bingxu Zhu , Yulian Geng , Aolei Liu , Wenfei Yin , Jian Liu

In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. One…

Image and Video Processing · Electrical Eng. & Systems 2024-09-16 Siyu , Lin , Haowen Zhou , Richard J. Cote , Mark Watson , Ramaswamy Govindan , Changhuei Yang

In addition to evaluating tumor morphology using H&E staining, immunohistochemistry is used to assess the presence of specific proteins within the tissue. However, this is a costly and labor-intensive technique, for which virtual staining,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 José Teixeira , Pascal Klöckner , Diana Montezuma , Melis Erdal Cesur , João Fraga , Hugo M. Horlings , Jaime S. Cardoso , Sara P. Oliveira

Unsupervised and unpaired domain translation using generative adversarial neural networks, and more precisely CycleGAN, is state of the art for the stain translation of histopathology images. It often, however, suffers from the presence of…

Computer Vision and Pattern Recognition · Computer Science 2022-07-04 Nicolas Brieu , Felix J. Segerer , Ansh Kapil , Philipp Wortmann , Guenter Schmidt

Lightweight deep learning models offer substantial reductions in computational cost and environmental impact, making them crucial for scientific applications. We present a lightweight CycleGAN for modality transfer in fluorescence…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Mohammad Soltaninezhad , Yashar Rouzbahani , Jhonatan Contreras , Rohan Chippalkatti , Daniel Kwaku Abankwa , Christian Eggeling , Thomas Bocklitz

Hazy images reduce the visibility of the image content, and haze will lead to failure in handling subsequent computer vision tasks. In this paper, we address the problem of image dehazing by proposing a dehazing network named T-Net, which…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Lirong Zheng , Yanshan Li , Kaihao Zhang , Wenhan Luo

Graph neural networks (GNNs) have been widely used in deep learning on graphs. They can learn effective node representations that achieve superior performances in graph analysis tasks such as node classification and node clustering.…

Machine Learning · Computer Science 2021-04-19 Jianxin Li , Hao Peng , Yuwei Cao , Yingtong Dou , Hekai Zhang , Philip S. Yu , Lifang He

The application of supervised deep learning methods in digital pathology is limited due to their sensitivity to domain shift. Digital Pathology is an area prone to high variability due to many sources, including the common practice of…

Image and Video Processing · Electrical Eng. & Systems 2020-12-24 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert

In real-world underwater environment, exploration of seabed resources, underwater archaeology, and underwater fishing rely on a variety of sensors, vision sensor is the most important one due to its high information content, non-intrusive,…

Image and Video Processing · Electrical Eng. & Systems 2021-03-29 Nan Wang , Yabin Zhou , Fenglei Han , Haitao Zhu , Jingzheng Yao

Generative models are widely employed to enhance the photorealism of visual synthetic data for training computer vision algorithms. However, they often introduce visual artifacts that degrade the accuracy of these algorithms and require…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Stefanos Pasios , Nikos Nikolaidis

Recent advancements in Low-Light Image Enhancement (LLIE) have focused heavily on Diffusion Probabilistic Models, which achieve high perceptual quality but suffer from significant computational latency (often exceeding 2-4 seconds per…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Yash Thesia , Meera Suthar