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The directed migration of cells toward stiffer substrate regions or durotaxis is relevant to tissue development and tumor progression. Here, we introduce a phenomenological model for single cell durotaxis that incorporates both elastic…

Soft Condensed Matter · Physics 2024-12-24 Subhaya Bose , Haiqin Wang , Xinpeng Xu , Arvind Gopinath , Kinjal Dasbiswas

A theoretical model for stratified epithelium is presented. The viscoelastic properties of the tissue is assumed to be dependent on the spatial distribution of proliferative and differentiated cells. Based on this assumption, a hydrodynamic…

Biological Physics · Physics 2016-06-08 Wei-Ting Yeh , Hsuan-Yi Chen

The onset of frictional sliding between contacting bodies under shear load is nucleated by the quasi-static growth of localized slip patches. After reaching a certain critical size, these patches become unstable and continue growing…

Soft Condensed Matter · Physics 2023-02-01 Miguel Castellano , Flavio Lorez , David Kammer

We study, by means of extensive direct numerical simulations, the turbulent flow produced by a two-dimensional cellular forcing in a cubic box with periodic boundary conditions. In spite of the strong anisotropy of the forcing, we find that…

Fluid Dynamics · Physics 2022-11-22 S. Berti , G. Boffetta , S. Musacchio

We study the surface fluctuations of a tissue with a dynamics dictated by cell-rearrangement, cell-division, and cell-death processes. Surface fluctuations are calculated in the homeostatic state, where cell division and cell death…

Biological Physics · Physics 2015-12-22 Thomas Risler , Aurélien Peilloux , Jacques Prost

We use computer simulations to analyse the yielding transition during large-amplitude oscillatory shear of a simple model for soft jammed solids. Simultaneous analysis of global mechanical response and particle-scale motion demonstrates…

Soft Condensed Matter · Physics 2016-09-07 Takeshi Kawasaki , Ludovic Berthier

Brittle materials exhibit sharp dynamical fractures when meeting Griffith's criterion, whereas ductile materials blunt a sharp crack by plastic responses. Upon continuous pulling ductile materials exhibit a necking instability which is…

Statistical Mechanics · Physics 2012-07-12 Olivier Dauchot , Smarajit Karmakar , Itamar Procaccia , Jacques Zylberg

Biological tissues transform between solid-like and liquid-like states in many fundamental physiological events. Recent experimental observations further suggest that in two-dimensional epithelial tissues these solid-liquid transformations…

Soft Condensed Matter · Physics 2024-05-06 Yiwen Tang , Siyuan Chen , Mark J. Bowick , Dapeng Bi

The balance between stretching and bending deformations characterizes shape transitions of thin elastic sheets. While stretching dominates the mechanical response in tension, bending dominates in compression after an abrupt buckling…

Biological Physics · Physics 2020-07-15 Pierre Recho , Jonathan Fouchard , Tom Wyatt , N. Khalilgharibi , Guillaume Charras , Alexandre Kabla

We study a mean field elastoplastic model, embedded within a disordered landscape of local yield barriers, to shed light on the behaviour of athermal amorphous solids subject to oscillatory shear. We show that the model presents a genuine…

Soft Condensed Matter · Physics 2022-05-25 Jack T. Parley , Srikanth Sastry , Peter Sollich

Predicting the flow of non-Newtonian fluids in porous structure is still a challenging issue due to the interplay betwen the microscopic disorder and the non-linear rheology. In this letter, we study the case of an yield stress fluid in a…

Soft Condensed Matter · Physics 2019-06-26 Chen Liu , Andrea De Luca , Alberto Rosso , Laurent Talon

The size and shape of a large variety of polymeric particles, including biological cells, star polymers, dendrimes, and microgels, depend on the applied stresses as the particles are extremely soft. In high-density suspensions these…

Statistical Mechanics · Physics 2018-04-11 Yan-Wei Li , Massimo Pica Ciamarra

During animal development and homeostasis, the structure of tissues, including muscles, blood vessels and connective tissues adapts to mechanical strains in the extracellular matrix (ECM). These strains originate from the differential…

Cell Behavior · Quantitative Biology 2017-03-06 Elisabeth G. Rens , Roeland M. H. Merks

The depletion interaction mediated by non-adsorbing polymers promotes condensation and assembly of repulsive colloidal particles into diverse higher-order structures and materials. One example, with particularly rich emergent behaviors, is…

Soft Condensed Matter · Physics 2016-02-23 Louis Kang , Thomas Gibaud , Zvonimir Dogic , T. C. Lubensky

We consider a randomly forced particle moving in a finite region, which rebounds inelastically with coefficient of restitution r on collision with the boundaries. We show that there is a transition at a critical value of r, r_c\equiv…

Statistical Mechanics · Physics 2009-10-31 Stephen J. Cornell , Michael R. Swift , Alan J. Bray

In the last decade many research efforts have been focused on understanding the rheology of disordered materials, and several theoretical predictions have been put forward regarding their yielding behavior. Nevertheless, not many…

Soft Condensed Matter · Physics 2021-06-29 Carlos Villarroel , Gustavo Düring

When a rod is vertically withdrawn from a granular layer, oblique force chains can be developed by effective shearing. In this study, the force-chain structure in a rod-withdrawn granular layer was experimentally investigated using a…

Soft Condensed Matter · Physics 2021-06-30 F. Okubo , H. Katsuragi

Tissue surface tension influences cell sorting and tissue fusion. Earlier mechanical studies suggest that multicellular spheroids actively reinforce their surface tension with applied force. Here we study this open question through…

Recent research has shown that motile cells can adapt their mode of propulsion to the mechanical properties of the environment in which they find themselves--crawling in some environments while swimming in others. The latter can involve…

Biological Physics · Physics 2018-05-24 Hao Wu , Marco Avila Ponce de Leon , Hans G. Othmer

Cell spreading requires a major reorganisation of the actin cytoskeleton, from a cortical structure to a lamellipodium where filaments are mostly parallel to the substrate. We propose a model inspired by the physics of nematic liquid…

Biological Physics · Physics 2019-06-07 Mathieu Dedenon , Pierre Sens