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The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…
SVM with an RBF kernel is usually one of the best classification algorithms for most data sets, but it is important to tune the two hyperparameters $C$ and $\gamma$ to the data itself. In general, the selection of the hyperparameters is a…
Convolutional Neural Networks (CNN) have gained great success in many artificial intelligence tasks. However, finding a good set of hyperparameters for a CNN remains a challenging task. It usually takes an expert with deep knowledge, and…
Long non-coding RNAs (lncRNAs) are important regulators to modulate gene expression and cell proliferation in the developing human brain. Previous methods mainly use bulk lncRNA and mRNA expression data to study lncRNA regulation. However,…
Single-cell RNA sequencing (scRNA-seq) has the potential to provide powerful, high-resolution signatures to inform disease prognosis and precision medicine. This paper takes an important first step towards this goal by developing an…
This paper introduces a novel deep metric learning-based semi-supervised regression (DML-S2R) method for parameter estimation problems. The proposed DML-S2R method aims to mitigate the problems of insufficient amount of labeled samples…
Recently, several optimization methods have been successfully applied to the hyperparameter optimization of deep neural networks (DNNs). The methods work by modeling the joint distribution of hyperparameter values and corresponding error.…
Hyperparameter tuning is one of the essential steps to guarantee the convergence of machine learning models. We argue that intuition about the optimal choice of hyperparameters for stochastic gradient descent can be obtained by studying a…
Inferring spatially resolved gene expression from histology images offers a cost-effective complement to spatial transcriptomics (ST). However, existing methods reduce this task to a simple morphology-to-expression mapping, where visual…
Most models in machine learning contain at least one hyperparameter to control for model complexity. Choosing an appropriate set of hyperparameters is both crucial in terms of model accuracy and computationally challenging. In this work we…
We explore the idea of automatically crafting a tuning dataset for Statistical Machine Translation (SMT) that makes the hyper-parameters of the SMT system more robust with respect to some specific deficiencies of the parameter tuning…
Deep Convolutional Neural Networks (CNNs) are widely employed in modern computer vision algorithms, where the input image is convolved iteratively by many kernels to extract the knowledge behind it. However, with the depth of convolutional…
While machine learning has advanced in medicine, its widespread use in clinical applications, especially in predicting breast cancer metastasis, is still limited. We have been dedicated to constructing a DFNN model to predict breast cancer…
Hyperspectral pansharpening has received much attention in recent years due to technological and methodological advances that open the door to new application scenarios. However, research on this topic is only now gaining momentum. The most…
Detecting maximal square submatrices of ones in binary matrices is a fundamental problem with applications in computer vision and pattern recognition. While the standard dynamic programming (DP) solution achieves optimal asymptotic…
In dynamic spectrum access (DSA) networks, secondary users (SUs) need to opportunistically access primary users' (PUs) radio spectrum without causing significant interference. Since the interaction between the SU and the PU systems are…
Cell recognition is a fundamental task in digital histopathology image analysis. Point-based cell recognition (PCR) methods normally require a vast number of annotations, which is extremely costly, time-consuming and labor-intensive.…
HybridQC is an R package that streamlines quality control (QC) of single-cell RNA sequencing (scRNA-seq) data by combining traditional threshold-based filtering with machine learning-based outlier detection. It provides an efficient and…
In this paper, the existing Scheduling Dimension Reduction (SDR) methods for Linear Parameter-Varying (LPV) models are reviewed and a Deep Neural Network (DNN) approach is developed that achieves higher model accuracy under scheduling…
Hyperparameter tuning is the black art of automatically finding a good combination of control parameters for a data miner. While widely applied in empirical Software Engineering, there has not been much discussion on which hyperparameter…