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Stimulus-responsive DNA-hydrogels with swelling capabilities are a promising class of materials for biomedical applications such as drug delivery and biosensing. However, translation of these systems to microscale applications requires…

Some microalgae store large amounts of neutral lipids inside lipid droplets. Since these lipids can be used to produce biodiesel in a sustainable way, research is developing on fast non-destructive methods to quantify and monitor the amount…

Biological Physics · Physics 2024-03-14 Catherine Yourassowsky , Renaud Theunissen , JÉrÔme Dohet-Eraly , Frank Dubois

Colloidal lithography has emerged as a promising alternative to conventional nanofabrication techniques, offering the ability to create nanoscale patterns in a cost-effective and scalable manner. However, it has been so far limited by…

Introduced more than fifty years ago, dynamic light scattering is routinely used to determine the size distribution of colloidal suspensions, as well as of macromolecules in solution, such as proteins, nucleic acids, and their complexes.…

Gaining access to the cell interior is fundamental for many applications, such as electrical recording, drug and biomolecular delivery. A very promising technique consists of culturing cells on nano/micro pillars. The tight adhesion and…

Lipid nanoparticles (LNPs) are vital in modern biomedicine, enabling the effective delivery of mRNA for vaccines and therapies by protecting it from rapid degradation. Among the components of LNPs, ionizable lipids play a key role in RNA…

Machine Learning · Computer Science 2024-12-03 Yuxuan Ou , Jingyi Zhao , Austin Tripp , Morteza Rasoulianboroujeni , José Miguel Hernández-Lobato

Uncovering the heterogeneity of cell populations is a long-standing goal in fields ranging from antimicrobial resistance to cancer research. Emerging technology platforms such as droplet microfluidics hold the promise to decipher cellular…

Image and Video Processing · Electrical Eng. & Systems 2020-01-29 Vasileios Anagnostidis , Benjamin Sherlock , Jeremy Metz , Philip Mair , Florian Hollfelder , Fabrice Gielen

Biolasers made of biological materials have attracted a great of research attention due to their biocompatibility and biodegradability, which have the potential for biosensors and biointegration. However, the current fabrication method of…

Micropatterning techniques have become an important tool for the study of cell behavior in controlled microenvironments. As a consequence, several approaches for the creation of micropatterns have been developed in recent years. However,…

Biological Physics · Physics 2016-02-05 F. J. Segerer , P. J. F. Röttgermann , S. Schuster , A. Piera Alberola , S. Zahler , J. O. Rädler

Subwavelength grating micro-polarizer arrays, as a type of focal plane division simultaneous detection method, are significantly advancing the development and practical application of polarization imaging technology. Based on the…

Optics · Physics 2024-10-17 Tianshi Lu , Fuyuan Deng , Yufeng Wei , Zhipeng Zeng , Xinghui Li

The formation of biomolecular condensates inside cells often involve intrinsically disordered proteins (IDPs), and several of these IDPs are also capable of forming droplet-like dense assemblies on their own, through liquid-liquid phase…

Biological Physics · Physics 2020-02-26 Daniel Nilsson , Anders Irbäck

Lipid bilayers often form high-curvature configurations due to self-assembly conditions or certain biological processes. However, particle-based simulations of lipid membranes are predominantly of flat lipid membranes because planar…

Soft Condensed Matter · Physics 2025-01-31 James Tallman , Antonia Statt

Droplet microlasers, as promising tools for biophotonics and biomedical sciences, have witnessed rapid advances due to their flexible reconfigurability, high sensitivity to stimuli, and label-free biosensing ability. However, designing…

Scalable technologies for the production of bio-compatible complex microfibers with controllable size and composition at competitively high throughput are urgently needed in order to meet the growing demand for such microstructures in…

Applied Physics · Physics 2022-08-11 Marangon Francesco , Baumgartner David , Planchette Carole

DNA and protein microarrays are a high-throughput technology that allow the simultaneous quantification of tens of thousands of different biomolecular species. The mediocre sensitivity and dynamic range of traditional fluorescence…

Biomolecules · Quantitative Biology 2018-01-24 Derin Sevenler , George Daaboul , Fulya Ekiz-Kanik , M. Selim Unlu

Significant progress has been made to increase access to droplet microfluidics for labs with limited microfluidics expertise or fabrication equipment. In particular, using off-the-shelf systems has been a valuable approach. However, the…

Microfluidics is an established multidisciplinary research domain with widespread applications in the fields of medicine, biotechnology and engineering. Conventional production methods of microfluidic chips have been limited to planar…

Miniaturizing nonlinear optical components is essential for integrating advanced light manipulation into compact photonic devices, enabling scalable and cost-effective applications. While monocrystalline lithium niobate thin films advance…

Droplet-based microfluidics systems have become widely used in recent years thanks to their advantages, varying from the possibility of handling small fluid volumes to directly synthesizing and encapsulating various living forms for…

Effective mixing is essential for biochemical reactions. In droplet-based microfluidics, immediate mixing of substances upon contact in the droplet formation stage can greatly enhance the uniformity of chemical reactions. Furthermore, it…