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The problem of RNA secondary structure design (also called inverse folding) is the following: given a target secondary structure, one aims to create a sequence that folds into, or is compatible with, a given structure. In several practical…

Quantitative Methods · Quantitative Biology 2013-08-02 Yu Zhou , Yann Ponty , Stéphane Vialette , Jérôme Waldispühl , Yi Zhang , Alain Denise

It had been proposed that overstretching double stranded DNA from the 5-5 ends will produce a new fiber form of dsDNA that is narrower than the S form that has been suggested to result when the dsDNA is overstretched from the 3-3 ends. We…

Soft Condensed Matter · Physics 2008-06-04 C. Limouse , C. Danilowicz , V. W. Coljee , N. Kleckner , M. Prentiss

Motivated by DNA based data storage system, we investigate the errors that occur when synthesizing DNA strands in parallel, where each strand is appended one nucleotide at a time by the machine according to a template supersequence. If…

Information Theory · Computer Science 2024-05-06 Ziyang Lu , Han Mao Kiah , Yiwei Zhang , Robert N. Grass , Eitan Yaakobi

A two-dimensional string is simply a two-dimensional array. We continue the study of the combinatorial properties of repetitions in such strings over the binary alphabet, namely the number of distinct tandems, distinct quartics, and runs.…

Formal Languages and Automata Theory · Computer Science 2021-06-01 Paweł Gawrychowski , Samah Ghazawi , Gad M. Landau

We consider the problem of identifying tandem scattered subsequences within a string. Our algorithm identifies a longest subsequence which occurs twice without overlap in a string. This algorithm is based on the Hunt-Szymanski algorithm,…

Data Structures and Algorithms · Computer Science 2020-06-26 Luís M. S. Russo , Alexandre P. Francisco

While achieving a compression ratio of 2.0 bits/base, the new algorithm codes non-N bases in fixed length. It dramatically reduces the time of coding and decoding than previous DNA compression algorithms and some universal compression…

Information Theory · Computer Science 2007-07-16 Jie Liu , Sheng Bao , Zhiqiang Jing , Shi Chen

MDS self-dual codes have good algebraic structure, and their parameters are completely determined by the code length. In recent years, the construction of MDS Euclidean self-dual codes with new lengths has become an important issue in…

Information Theory · Computer Science 2025-04-03 Weirong Meng , Weijun Fang , Fang-Wei Fu , Haiyan Zhou , Ziyi Gu

We extend Ziv and Lempel's model of finite-state encoders to the realm of lossy compression of individual sequences. In particular, the model of the encoder includes a finite-state reconstruction codebook followed by an information lossless…

Information Theory · Computer Science 2024-01-04 Neri Merhav

A new method to identify all sufficiently long repeating substrings in one or several symbol sequences is proposed. The method is based on a specific gauge applied to symbol sequences that guarantees identification of the repeating…

Genomics · Quantitative Biology 2016-04-07 Sergey Tsarev , Michael Sadovsky

We investigate the fundamental limits of the recently proposed random access coverage depth problem for DNA data storage. Under this paradigm, it is assumed that the user information consists of $k$ information strands, which are encoded…

Information Theory · Computer Science 2025-09-25 Anina Gruica , Daniella Bar-Lev , Alberto Ravagnani , Eitan Yaakobi

Reconstructing the tree of life from molecular sequences is a fundamental problem in computational biology. Modern data sets often contain a large number of genes, which can complicate the reconstruction problem due to the fact that…

Probability · Mathematics 2017-07-21 Constantinos Daskalakis , Sebastien Roch

Random linear network coding (RLNC) in theory achieves the max-flow capacity of multicast networks, at the cost of high decoding complexity. To improve the performance-complexity tradeoff, we consider the design of sparse network codes. A…

Information Theory · Computer Science 2016-04-20 Ye Li , Wai-Yip Chan , Steven D. Blostein

We introduce the graph parameter readability and study it as a function of the number of vertices in a graph. Given a digraph D, an injective overlap labeling assigns a unique string to each vertex such that there is an arc from x to y if…

Discrete Mathematics · Computer Science 2015-04-22 Rayan Chikhi , Paul Medvedev , Martin Milanic , Sofya Raskhodnikova

This paper introduces Redescription Model Mining, a novel approach to identify interpretable patterns across two datasets that share only a subset of attributes and have no common instances. In particular, Redescription Model Mining aims to…

Databases · Computer Science 2021-07-12 Felix I. Stamm , Martin Becker , Markus Strohmaier , Florian Lemmerich

We present TreeClone, a latent feature allocation model to reconstruct tumor subclones subject to phylogenetic evolution that mimics tumor evolution. Similar to most current methods, we consider data from next-generation sequencing of tumor…

Applications · Statistics 2017-10-26 Tianjian Zhou , Subhajit Sengupta , Peter Mueller , Yuan Ji

List-decoding and list-recovery are important generalizations of unique decoding that received considerable attention over the years. However, the optimal trade-off among list-decoding (resp. list-recovery) radius, list size, and the code…

Information Theory · Computer Science 2021-12-13 Eitan Goldberg , Chong Shangguan , Itzhak Tamo

In this paper, we develop the theory for constructing DNA cyclic codes of odd length over $R=\Z_4[u]/\langle u^2-1 \rangle$ based on the deletion distance. Firstly, we relate DNA pairs with a special 16 elements of ring $R$. Cyclic codes of…

Information Theory · Computer Science 2016-03-15 Sukhamoy Pattanayak , Abhay Kumar Singh

Biological sequence analysis relies on the ability to denoise the imprecise output of sequencing platforms. We consider a common setting where a short sequence is read out repeatedly using a high-throughput long-read platform to generate…

Genomics · Quantitative Biology 2023-09-06 Nathan Ng , Ji Won Park , Jae Hyeon Lee , Ryan Lewis Kelly , Stephen Ra , Kyunghyun Cho

In this paper, we study error exponents for a concatataned coding based class of DNA storage codes in which the number of reads performed can be variable. That is, the decoder can sequentially perform reads and choose whether to output the…

Information Theory · Computer Science 2025-04-25 Yan Hao Ling , Nir Weinberger , Jonathan Scarlett

This work introduces a novel approach to constructing DNA codes from linear codes over a non-chain extension of $\mathbb{Z}_4$. We study $(\text{\textbaro},\mathfrak{d}, \gamma)$-constacyclic codes over the ring…

Information Theory · Computer Science 2025-02-25 Priyanka Sharma , Ashutosh Singh , Om Prakash