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Alzheimer's disease (AD) is a common form of dementia that severely impacts patient health. As AD impairs the patient's language understanding and expression ability, the speech of AD patients can serve as an indicator of this disease. This…

Audio and Speech Processing · Electrical Eng. & Systems 2023-07-07 Hongmin Cai , Xiaoke Huang , Zhengliang Liu , Wenxiong Liao , Haixing Dai , Zihao Wu , Dajiang Zhu , Hui Ren , Quanzheng Li , Tianming Liu , Xiang Li

Major Depressive Disorder is one of the leading causes of disability worldwide, yet its diagnosis still depends largely on subjective clinical assessments. Integrating Artificial Intelligence (AI) holds promise for developing objective,…

Artificial Intelligence · Computer Science 2026-05-01 Dorsa Macky Aleagha , Payam Zohari , Mostafa Haghir Chehreghani

A wide variety of methods have been developed for identifying depression, but they focus primarily on measuring the degree to which individuals are suffering from depression currently. In this work we explore the possibility of predicting…

Machine Learning · Computer Science 2022-03-22 Guansong Pang , Ngoc Thien Anh Pham , Emma Baker , Rebecca Bentley , Anton van den Hengel

In recent years there has been a burgeoning interest in the use of computational methods to distinguish between elicited speech samples produced by patients with dementia, and those from healthy controls. The difference between perplexity…

Computation and Language · Computer Science 2020-06-30 Trevor Cohen , Serguei Pakhomov

Mental distress like depression and anxiety contribute to the largest proportion of the global burden of diseases. Automated diagnosis systems of such disorders, empowered by recent innovations in Artificial Intelligence, can pave the way…

Audio and Speech Processing · Electrical Eng. & Systems 2023-06-23 Mashrura Tasnim , Malikeh Ehghaghi , Brian Diep , Jekaterina Novikova

Cognitive decline often surfaces in language years before diagnosis. It is frequently non-experts, such as those closest to the patient, who first sense a change and raise concern. As LLMs become integrated into daily communication and used…

Computation and Language · Computer Science 2025-05-20 Lotem Peled-Cohen , Maya Zadok , Nitay Calderon , Hila Gonen , Roi Reichart

Depression is a growing concern gaining attention in both public discourse and AI research. While deep neural networks (DNNs) have been used for recognition, they still lack real-world effectiveness. Large language models (LLMs) show strong…

Human-Computer Interaction · Computer Science 2025-08-27 Yupei Li , Shuaijie Shao , Manuel Milling , Björn W. Schuller

Early detection of dementia is critical for timely medical intervention and improved patient outcomes. Neuropsychological tests are widely used for cognitive assessment but have traditionally relied on manual scoring. Automatic dementia…

Machine Learning · Computer Science 2025-07-15 Liming Wang , Saurabhchand Bhati , Cody Karjadi , Rhoda Au , James Glass

Depression and anxiety are psychiatric disorders that are observed in many areas of everyday life. For example, these disorders manifest themselves somewhat frequently in texts written by nondiagnosed users in social media. However,…

Computation and Language · Computer Science 2020-11-11 David Owen , Jose Camacho Collados , Luis Espinosa-Anke

With the acceleration of the pace of work and life, people have to face more and more pressure, which increases the possibility of suffering from depression. However, many patients may fail to get a timely diagnosis due to the serious…

Signal Processing · Electrical Eng. & Systems 2021-06-02 Lang He , Mingyue Niu , Prayag Tiwari , Pekka Marttinen , Rui Su , Jiewei Jiang , Chenguang Guo , Hongyu Wang , Songtao Ding , Zhongmin Wang , Wei Dang , Xiaoying Pan

The ADReSS Challenge at INTERSPEECH 2020 defines a shared task through which different approaches to the automated recognition of Alzheimer's dementia based on spontaneous speech can be compared. ADReSS provides researchers with a benchmark…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-07 Saturnino Luz , Fasih Haider , Sofia de la Fuente , Davida Fromm , Brian MacWhinney

We propose a novel explainable machine learning (ML) model that identifies depression from speech, by modeling the temporal dependencies across utterances and utilizing the spectrotemporal information at the vowel level. Our method first…

Sound · Computer Science 2022-10-28 Kexin Feng , Theodora Chaspari

Depression is increasingly impacting individuals both physically and psychologically worldwide. It has become a global major public health problem and attracts attention from various research fields. Traditionally, the diagnosis of…

Human-Computer Interaction · Computer Science 2022-02-28 Kaining Mao , Wei Zhang , Deborah Baofeng Wang , Ang Li , Rongqi Jiao , Yanhui Zhu , Bin Wu , Tiansheng Zheng , Lei Qian , Wei Lyu , Minjie Ye , Jie Chen

The diversity of cognitive deficits and neuropathological processes associated with dementias has encouraged divergence in pathophysiological explanations of disease. Here, we review an alternative framework that emphasises convergent…

Neurons and Cognition · Quantitative Biology 2020-06-12 Ece Kocagoncu , Anastasia Klimovich-Gray , Laura E Hughes , James B Rowe

Alzheimers disease is a fatal progressive brain disorder that worsens with time. It is high time we have inexpensive and quick clinical diagnostic techniques for early detection and care. In previous studies, various Machine Learning…

Computation and Language · Computer Science 2021-09-27 Akshay Valsaraj , Ithihas Madala , Nikhil Garg , Veeky Baths

Alzheimer's Disease (AD) is nowadays the most common form of dementia, and its automatic detection can help to identify symptoms at early stages, so that preventive actions can be carried out. Moreover, non-intrusive techniques based on…

Computation and Language · Computer Science 2020-11-21 Mireia Farrús , Joan Codina-Filbà

Dementia is a complex syndrome impacting cognitive and emotional functions, with Alzheimer's disease being the most common form. This study focuses on enhancing dementia prediction using machine learning (ML) techniques on patient health…

Artificial Intelligence · Computer Science 2026-01-13 Shafiul Ajam Opee , Nafiz Fahad , Anik Sen , Rasel Ahmed , Fariha Jahan , Md. Kishor Morol , Md Rashedul Islam

Early diagnosis of Alzheimer's Disease (AD) faces multiple data-related challenges, including high variability in patient data, limited access to specialized diagnostic tests, and overreliance on single-type indicators. These challenges are…

Quantitative Methods · Quantitative Biology 2025-03-05 Yizong Xing , Dhita Putri Pratama , Yuke Wang , Yufan Zhang , Brian E. Chapman

Early detection and treatment of depression is essential in promoting remission, preventing relapse, and reducing the emotional burden of the disease. Current diagnoses are primarily subjective, inconsistent across professionals, and…

Machine Learning · Computer Science 2020-02-03 Karol Chlasta , Krzysztof Wołk , Izabela Krejtz

Data harmonization is the process by which an equivalence is developed between two variables measuring a common trait. Our problem is motivated by dementia research in which multiple tests are used in practice to measure the same underlying…

Methodology · Statistics 2021-10-13 Steven Wilkins-Reeves , Yen-Chi Chen , Kwun Chuen Gary Chan