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The generation of accurate 3D molecular conformations is a pivotal challenge in computational chemistry and drug discovery. Recently, diffusion and flow matching models have achieved remarkable success. However, there is a critical…

Machine Learning · Computer Science 2026-05-26 Yunqing Liu , Yi Zhou , Wenqi Fan

Multi-objective optimization (MOO) aims to optimize multiple, possibly conflicting objectives with widespread applications. We introduce a novel interacting particle method for MOO inspired by molecular dynamics simulations. Our approach…

Machine Learning · Computer Science 2024-11-22 Yinuo Ren , Tesi Xiao , Tanmay Gangwani , Anshuka Rangi , Holakou Rahmanian , Lexing Ying , Subhajit Sanyal

We combine integer linear programming and recent advances in Monadic Second-Order model checking to obtain two new algorithmic meta-theorems for graphs of bounded vertex-cover. The first shows that cardMSO1, an extension of the well-known…

Data Structures and Algorithms · Computer Science 2013-06-25 Robert Ganian , Jan Obdržálek

Bayesian Optimization (BO) is a popular approach to optimizing expensive-to-evaluate black-box functions. Despite the success of BO, its performance may decrease exponentially as the dimensionality increases. A common framework to tackle…

Machine Learning · Computer Science 2024-12-24 Quoc-Anh Hoang Nguyen , The Hung Tran

Many complex systems obey to optimality conditions that are usually not simple. Conflicting traits often interact making a Multi Objective Optimization (MOO) approach necessary. Recent MOO research on complex systems report about the Pareto…

Physics and Society · Physics 2015-09-16 Luís F. Seoane , Ricard Solé

Although Bayesian Optimization (BO) has been employed for accelerating materials design in computational materials engineering, existing works are restricted to problems with quantitative variables. However, real designs of materials…

Machine Learning · Statistics 2019-10-07 Yichi Zhang , Daniel Apley , Wei Chen

Multilook coherent imaging is a widely used technique in applications such as digital holography, ultrasound imaging, and synthetic aperture radar. A central challenge in these systems is the presence of multiplicative noise, commonly known…

Machine Learning · Statistics 2025-05-30 Xi Chen , Soham Jana , Christopher A. Metzler , Arian Maleki , Shirin Jalali

The imaging depth of deep-tissue optical microscopy is governed by the performance of the gating operation that suppresses the multiply scattered waves obscuring the ballistic waves. Although various gating operations based on confocal,…

This paper presents a multi-staged approach to nonmyopic adaptive Gaussian process optimization (GPO) for Bayesian optimization (BO) of unknown, highly complex objective functions that, in contrast to existing nonmyopic adaptive BO…

Machine Learning · Computer Science 2020-02-25 Dmitrii Kharkovskii , Chun Kai Ling , Kian Hsiang Low

Accurate and efficient modeling of large-scale urban scenes is critical for applications such as AR navigation, UAV based inspection, and smart city digital twins. While aerial imagery offers broad coverage and complements limitations of…

Graphics · Computer Science 2025-06-10 Weihang Liu , Yuhui Zhong , Yuke Li , Xi Chen , Jiadi Cui , Honglong Zhang , Lan Xu , Xin Lou , Yujiao Shi , Jingyi Yu , Yingliang Zhang

Standard Bayesian Optimization (BO) assumes uniform smoothness across the search space an assumption violated in multi-regime problems such as molecular conformation search through distinct energy basins or drug discovery across…

Machine Learning · Computer Science 2026-01-29 Yan Zhang , Xuefeng Liu , Sipeng Chen , Sascha Ranftl , Chong Liu , Shibo Li

We consider feasibility and constrained optimization problems defined over smooth and/or strongly convex sets. These notions mirror their popular function counterparts but are much less explored in the first-order optimization literature.…

Optimization and Control · Mathematics 2025-10-02 Ning Liu , Benjamin Grimmer

Data-driven materials design often encounters challenges where systems require or possess qualitative (categorical) information. Metal-organic frameworks (MOFs) are an example of such material systems. The representation of MOFs through…

Materials Science · Physics 2023-11-16 Yigitcan Comlek , Thang Duc Pham , Randall Snurr , Wei Chen

Combinatorial Optimization (CO) addresses many important problems, including the challenging Maximum Independent Set (MIS) problem. Alongside exact and heuristic solvers, differentiable approaches have emerged, often using continuous…

Discrete Mathematics · Computer Science 2025-06-10 Ismail Alkhouri , Cedric Le Denmat , Yingjie Li , Cunxi Yu , Jia Liu , Rongrong Wang , Alvaro Velasquez

Optical metasurfaces (subwavelength-patterned surfaces typically described by variable effective surface impedances) are typically modeled by an approximation akin to ray optics: the reflection or transmission of an incident wave at each…

Recently, 3D Gaussian Splatting (3DGS) has demonstrated impressive novel view synthesis results, while allowing the rendering of high-resolution images in real-time. However, leveraging 3D Gaussians for surface reconstruction poses…

Computer Vision and Pattern Recognition · Computer Science 2024-09-12 Zehao Yu , Torsten Sattler , Andreas Geiger

Gaussian Splatting (GS) is a recent and pivotal technique in 3D computer graphics. GS-based algorithms almost always bypass classical methods such as ray tracing, which offer numerous inherent advantages for rendering. For example, ray…

In high-dimensional settings, Bayesian optimization (BO) can be expensive and infeasible. The random embedding Bayesian optimization algorithm is commonly used to address high-dimensional BO challenges. However, this method relies on the…

Machine Learning · Computer Science 2024-08-12 Jiaming Lu , Rong J. B. Zhu

A mirrored transformation optics (MTO) approach is presented to overcome the material mismatch in transformation optics. It makes good use of the reflection behavior and introduce a mirrored medium to offset the phase discontinuities. Using…

Optics · Physics 2023-11-23 Junke Liao , Pengfei Zhao , Zhinbing Zhang , Wen Xiao , Huanyang Chen

Gradient-based trajectory optimization (GTO) has gained wide popularity for quadrotor trajectory replanning. However, it suffers from local minima, which is not only fatal to safety but also unfavorable for smooth navigation. In this paper,…

Robotics · Computer Science 2020-04-17 Boyu Zhou , Fei Gao , Jie Pan , Shaojie Shen
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