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We report the development of a laboratory-based Rowland-circle monochromator that incorporates a low poer x-ray (bremsstrahlung) tube source, a spherically-bent crystal analyzer (SBCA), and an energy-resolving solid-state detector. This…

High-resolution x-ray tomography is a common technique for biomedical research using synchrotron sources. With advancements in laboratory x-ray sources, an increasing number of experiments can be performed in the lab. In this paper, the…

Instrumentation and Detectors · Physics 2024-08-23 Till Dreier , Robin Krüger , Gustaf Bernström , Karin Tran-Lundmark , Isabel Gonçalves , Martin Bech

We present a low-cost laboratory X-ray absorption spectrometer that uses a conventional X-ray tube source and bent Johann-type crystal monochromators. The instrument is designed for XAS studies in the 4-20 keV range which covers most K…

Instrumentation and Detectors · Physics 2019-05-01 Ari-Pekka Honkanen , Sami Ollikkala , Taru Ahopelto , Antti-Jussi Kallio , Merja Blomberg , Simo Huotari

X-ray ptychography has revolutionised nanoscale phase contrast imaging at large-scale synchrotron sources in recent years. We present here the first successful demonstration of the technique in a small-scale laboratory setting. We conducted…

X-ray fluorescence computed tomography based on sheet-beam can save a huge amount of time to obtain a whole set of projections using synchrotron. However, it is clearly unpractical for most biomedical research laboratories. In this paper,…

Medical Physics · Physics 2017-03-07 Shanghai Jiang , Peng He , Luzhen Deng , Mianyi Chen , Biao Wei

We present a multi-aperture analyser set-up for performing X-ray phase contrast imaging in planar and three-dimensional modalities. A multi-slice representation of the sample is used to establish a quantitative relation between projection…

Instrumentation and Detectors · Physics 2017-06-21 M. Endrizzi , F. A. Vittoria , L. Rigon , D. Dreossi , A. Olivo

Ghost tomography using single-pixel detection extends the emerging field of ghost imaging to three dimensions, with the use of penetrating radiation. In this work, a series of spatially random x-ray intensity patterns is used to illuminate…

Instrumentation and Detectors · Physics 2019-06-25 Andrew. M. Kingston , Daniele Pelliccia , Alexander Rack , Margie P. Olbinado , Yin Cheng , Glenn R. Myers , David M. Paganin

We demonstrate dark-field x-ray microtomography in a compact, laboratory-based system capable of resolving attenuation, phase, and anisotropic scattering signals with micrometer-scale resolution across centimetre-scale samples. The method…

X-ray absorption spectroscopy is a crucial experimental technique for elucidating the mechanisms of structural degradation in battery materials. However, extracting information from the measured spectrum is challenging without high-quality…

X-ray calorimeters routinely achieve very high spectral resolution, typically a few eV full width at half maximum (FWHM). Measurements of calorimeter line shapes are usually dominated by the natural linewidth of most laboratory calibration…

Instrumentation and Methods for Astrophysics · Physics 2020-08-17 M. A. Leutenegger , M. E. Eckart , S. J. Moseley , S. O. Rohrbach , J. K. Black , M. P. Chiao , R. L. Kelley , C. A. Kilbourne , F. S. Porter

Electron tomography is a technique used in both materials science and structural biology to image features well below optical resolution limit. In this work, we present a new algorithm for reconstructing the three-dimensional(3D)…

Signal Processing · Electrical Eng. & Systems 2018-07-12 David Ren , Michael Chen , Laura Waller , Colin Ophus

We demonstrate high-resolution non-iterative holographic coherent diffraction imaging with hard X-rays using a novel phase-shifting reference, fabricated by atomic layer deposition to produce nanosharp 3D structure. The method surpasses the…

Mesoscale and Nanoscale Physics · Physics 2016-10-17 Mirna Saliba , Jeroen Bosgra , Christoph Rau , Christian David , Aaron D. Parsons , Ulrich H. Wagner , Pierre Thibault

We report the first experimental test of an analytic image reconstruction algorithm for optical tomography with large data sets. Using a continuous-wave optical tomography system with 10^8 source-detector pairs, we demonstrate the…

Medical Physics · Physics 2007-05-23 Zheng-Min Wang , George Y. Panasyuk , Vadim A. Markel , John C. Schotland

We propose an imaging system and methodology for mapping soft-tissue samples in three dimensions, with micron-scale and isotropic spatial resolution, with low-concentrations as well as in the absence of heavy metal staining. We used hard…

Instrumentation and Detectors · Physics 2023-12-21 Michela Esposito , Nicole Schieber , Alessandro Olivo , Yannick Schwab , Marco Endrizzi

X-ray computed tomography is a powerful tool for volumetric imaging, where three-dimensional (3D) images are generated from a large number of individual X-ray projection images. Collecting the required number of low noise projection images…

Image and Video Processing · Electrical Eng. & Systems 2025-04-30 Zhenduo Shang , Thomas Blumensath

This work presents a high-resolution X-ray microtomography system that uses commercial off-the-shelf (COTS) CMOS image sensors as direct detectors, relying on the sensor s intrinsic resolution to achieve tomographic reconstructions without…

Image and Video Processing · Electrical Eng. & Systems 2026-05-29 Damian L. Corzi , Jose Lipovetzky , Fabricio Alcalde Bessia , German Mato , Andres Cicuttin , Maria L. Crespo , Martin Perez , Mariano Gomez Berisso

In X-ray imaging, photons are transmitted through and absorbed by the subject, but are also scattered in significant quantities. Previous attempts to use scattered photons for biological imaging used pencil or fan beam illumination. Here we…

In a comprehensive study on several samples we demonstrate for our laboratory-based computed tomography system resolutions down to 150nm. The achieved resolution is validated by imaging com-mon test structures in 2D and Fourier Shell…

Instrumentation and Detectors · Physics 2021-02-15 Dominik Müller , Jonas Graetz , Andreas Balles , Simon Stier , Randolf Hanke , Christian Fella

X-ray dark-field imaging creates a representation of the sample where contrast is generated by subresolution features within the volume under inspection. These are detected by a local measurement of the radiation field's angular…

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