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Recent advances in Language Models have enabled the protein modeling community with a powerful tool since protein sequences can be represented as text. Specifically, by taking advantage of Transformers, sequence-to-property prediction will…

Biomolecules · Quantitative Biology 2023-09-07 Chakradhar Guntuboina , Adrita Das , Parisa Mollaei , Seongwon Kim , Amir Barati Farimani

Machine learning has rapidly advanced the design and discovery of new materials with targeted applications in various systems. First-principles calculations and other computer experiments have been integrated into material design pipelines…

In drug-discovery-related tasks such as virtual screening, machine learning is emerging as a promising way to predict molecular properties. Conventionally, molecular fingerprints (numerical representations of molecules) are calculated…

Machine Learning · Computer Science 2019-11-13 Shion Honda , Shoi Shi , Hiroki R. Ueda

A novel framework has recently been proposed for designing the molecular structure of chemical compounds with a desired chemical property using both artificial neural networks and mixed integer linear programming. In this paper, we design a…

We present a novel multimodal language model approach for predicting molecular properties by combining chemical language representation with physicochemical features. Our approach, MULTIMODAL-MOLFORMER, utilizes a causal multistage feature…

Data-driven approaches are particularly useful for computational materials discovery and design as they can be used for rapidly screening over a very large number of materials, thus suggesting lead candidates for further in-depth…

Materials Science · Physics 2015-07-09 Tran Doan Huan , Arun Mannodi-Kanakkithodi , Rampi Ramprasad

SMILES is a linear representation of chemical structures which encodes the connection table, and the stereochemistry of a molecule as a line of text with a grammar structure denoting atoms, bonds, rings and chains, and this information can…

Machine Learning · Computer Science 2018-12-03 Arindam Paul , Dipendra Jha , Reda Al-Bahrani , Wei-keng Liao , Alok Choudhary , Ankit Agrawal

Building multi-modal language models has been a trend in the recent years, where additional modalities such as image, video, speech, etc. are jointly learned along with natural languages (i.e., textual information). Despite the success of…

Computation and Language · Computer Science 2023-10-30 Mohammad Akbari , Saeed Ranjbar Alvar , Behnam Kamranian , Amin Banitalebi-Dehkordi , Yong Zhang

An overwhelmingly large amount of knowledge in the materials domain is generated and stored as text published in peer-reviewed scientific literature. Recent developments in natural language processing, such as bidirectional encoder…

Computation and Language · Computer Science 2021-10-01 Tanishq Gupta , Mohd Zaki , N. M. Anoop Krishnan , Mausam

This paper presents UniBERT, a compact multilingual language model that uses an innovative training framework that integrates three components: masked language modeling, adversarial training, and knowledge distillation. Pre-trained on a…

Computation and Language · Computer Science 2025-09-03 Andrei-Marius Avram , Marian Lupaşcu , Dumitru-Clementin Cercel , Ionuţ Mironică , Ştefan Trăuşan-Matu

CHEMSMART (Chemistry Simulation and Modeling Automation Toolkit) is an open-source, Python-based framework designed to streamline quantum chemistry workflows for homogeneous catalysis and molecular modeling. By integrating job preparation,…

Chemical Physics · Physics 2025-08-28 Xinglong Zhang , Huiwen Tan , Jingyi Liu , Zihan Li , Lewen Wang , Benjamin W. J. Chen

Language modeling has seen impressive progress over the last years, mainly prompted by the invention of the Transformer architecture, sparking a revolution in many fields of machine learning, with breakthroughs in chemistry and biology. In…

Machine Learning · Computer Science 2023-10-11 Andres M Bran , Philippe Schwaller

Synthetic polymeric materials underpin fundamental technologies in the energy, electronics, consumer goods, and medical sectors, yet their development still suffers from prolonged design timelines. Although polymer informatics tools have…

Computational Engineering, Finance, and Science · Computer Science 2025-06-12 Ayush Jain , Rampi Ramprasad

Developing large-scale foundational datasets is a critical milestone in advancing artificial intelligence (AI)-driven scientific innovation. However, unlike AI-mature fields such as natural language processing, materials science,…

Chemical Physics · Physics 2025-11-18 Ryo Yoshida , Yoshihiro Hayashi , Hidemine Furuya , Ryohei Hosoya , Kazuyoshi Kaneko , Hiroki Sugisawa , Yu Kaneko , Aiko Takahashi , Yoh Noguchi , Shun Nanjo , Keiko Shinoda , Tomu Hamakawa , Mitsuru Ohno , Takuya Kitamura , Misaki Yonekawa , Stephen Wu , Masato Ohnishi , Chang Liu , Teruki Tsurimoto , Arifin , Araki Wakiuchi , Kohei Noda , Junko Morikawa , Teruaki Hayakawa , Junichiro Shiomi , Masanobu Naito , Kazuya Shiratori , Tomoki Nagai , Norio Tomotsu , Hiroto Inoue , Ryuichi Sakashita , Masashi Ishii , Isao Kuwajima , Kenji Furuichi , Norihiko Hiroi , Yuki Takemoto , Takahiro Ohkuma , Keita Yamamoto , Naoya Kowatari , Masato Suzuki , Naoya Matsumoto , Seiryu Umetani , Hisaki Ikebata , Yasuyuki Shudo , Mayu Nagao , Shinya Kamada , Kazunori Kamio , Taichi Shomura , Kensaku Nakamura , Yudai Iwamizu , Atsutoshi Abe , Koki Yoshitomi , Yuki Horie , Katsuhiko Koike , Koichi Iwakabe , Shinya Gima , Kota Usui , Gikyo Usuki , Takuro Tsutsumi , Keitaro Matsuoka , Kazuki Sada , Masahiro Kitabata , Takuma Kikutsuji , Akitaka Kamauchi , Yusuke Iijima , Tsubasa Suzuki , Takenori Goda , Yuki Takabayashi , Kazuko Imai , Yuji Mochizuki , Hideo Doi , Koji Okuwaki , Hiroya Nitta , Taku Ozawa , Hitoshi Kamijima , Toshiaki Shintani , Takuma Mitamura , Massimiliano Zamengo , Yuitsu Sugami , Seiji Akiyama , Yoshinari Murakami , Atsushi Betto , Naoya Matsuo , Satoru Kagao , Tetsuya Kobayashi , Norie Matsubara , Shosei Kubo , Yuki Ishiyama , Yuri Ichioka , Mamoru Usami , Satoru Yoshizaki , Seigo Mizutani , Yosuke Hanawa , Shogo Kunieda , Mitsuru Yambe , Takeru Nakamura , Hiromori Murashima , Kenji Takahashi , Naoki Wada , Masahiro Kawano , Yosuke Harada , Takehiro Fujita , Erina Fujita , Ryoji Himeno , Hiori Kino , Kenji Fukumizu

High-throughput computational screening of polymers offers a powerful way to address the imbalance between the vast number of polymers synthesised for diverse applications and the relatively small subset that can be studied using atomistic…

Materials Science · Physics 2026-03-12 Lois Smith , Samuel Ericson , Vittoria Fantauzzo , Chin Yong , Paola Carbone , Alessandro Troisi

Exploring the predictive capabilities of language models in material science is an ongoing interest. This study investigates the application of language model embeddings to enhance material property prediction in materials science. By…

Computation and Language · Computer Science 2024-11-05 Yuwei Wan , Tong Xie , Nan Wu , Wenjie Zhang , Chunyu Kit , Bram Hoex

Understanding and predicting polymer solubility in various solvents is critical for applications ranging from recycling to pharmaceutical formulation. This work presents a deep learning framework that predicts polymer solubility, expressed…

Machine Learning · Computer Science 2025-12-11 Andrew Reinhard

With the emergence of Transformer architectures and their powerful understanding of textual data, a new horizon has opened up to predict the molecular properties based on text description. While SMILES are the most common form of…

Chemical Physics · Physics 2023-10-11 Suryanarayanan Balaji , Rishikesh Magar , Yayati Jadhav , Amir Barati Farimani

Machine learning has revolutionized many fields, including materials science. However, predicting properties of crystalline materials using machine learning faces challenges in input encoding, output versatility, and interpretability. We…

Materials Science · Physics 2025-05-22 Haosheng Xu , Dongheng Qian , Jing Wang

Therapeutic peptides have emerged as a pivotal modality in modern drug discovery, occupying a chemically and topologically rich space. While accurate prediction of their physicochemical properties is essential for accelerating peptide…

Machine Learning · Computer Science 2025-12-30 Seungeon Lee , Takuto Koyama , Itsuki Maeda , Shigeyuki Matsumoto , Yasushi Okuno