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2D display is a fast and economical way of visualizing polymorphism and comparing genomes, which is based on the separation of DNA fragments in two steps, according first to their size and then to their sequence composition. In this paper,…

Biomolecules · Quantitative Biology 2009-10-29 Ana-Maria Florescu , Marc Joyeux , Benedicte Lafay

Recent developments in deep learning-based methods demonstrated its potential to predict the 3D protein structures using inputs such as protein sequences, Cryo-Electron microscopy (Cryo-EM) images of proteins, etc. However, these methods…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Jaydeep Rade , Soumik Sarkar , Anwesha Sarkar , Adarsh Krishnamurthy

Artificial Intelligence (AI) has the potential to revolutionize diagnosis and segmentation in medical imaging. However, development and clinical implementation face multiple challenges including limited data availability, lack of…

Image and Video Processing · Electrical Eng. & Systems 2025-01-22 Zelong Liu , Andrew Tieu , Nikhil Patel , Georgios Soultanidis , Louisa Deyer , Ying Wang , Sean Huver , Alexander Zhou , Yunhao Mei , Zahi A. Fayad , Timothy Deyer , Xueyan Mei

In this work we present a system based on a Deep Learning approach, by using a Convolutional Neural Network, capable of classifying protein chains of amino acids based on the protein description contained in the Protein Data Bank. Each…

Machine Learning · Computer Science 2021-11-04 Damiano Perri , Marco Simonetti , Andrea Lombardi , Noelia Faginas-Lago , Osvaldo Gervasi

Visual recognition models are not invariant to viewpoint changes in the 3D world, as different viewing directions can dramatically affect the predictions given the same object. Although many efforts have been devoted to making neural…

Computer Vision and Pattern Recognition · Computer Science 2023-07-21 Shouwei Ruan , Yinpeng Dong , Hang Su , Jianteng Peng , Ning Chen , Xingxing Wei

We explicitly show the connection between the protein folding problem and spin glass transition. This is then used to identify appropriate quantities that are required to describe the transition. A possible way of observing the spin glass…

Condensed Matter · Physics 2015-06-25 S. Suresh Rao , Somendra M. Bhattacharjee

Changes in the extent of local concavity along with changes in surface roughness of binding sites of proteins have long been considered as useful markers to identify functional sites of proteins. However, an algorithm that describes the…

Biomolecules · Quantitative Biology 2011-11-29 Anirban Banerji

We present a new perspective on bridging the generalization gap between biological and computer vision -- mimicking the human visual diet. While computer vision models rely on internet-scraped datasets, humans learn from limited 3D scenes…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Spandan Madan , You Li , Mengmi Zhang , Hanspeter Pfister , Gabriel Kreiman

Recent medical vision-language models (VLMs) have shown promise in 2D medical image interpretation. However extending them to 3D medical imaging has been challenging due to computational complexities and data scarcity. Although a few recent…

Image and Video Processing · Electrical Eng. & Systems 2024-12-19 Changsun Lee , Sangjoon Park , Cheong-Il Shin , Woo Hee Choi , Hyun Jeong Park , Jeong Eun Lee , Jong Chul Ye

While electron microscopy offers crucial atomic-resolution insights into structure-property relationships, radiation damage severely limits its use on beam-sensitive materials like proteins and 2D materials. To overcome this challenge, we…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Zifei Wang , Zian Mao , Xiaoya He , Xi Huang , Haoran Zhang , Chun Cheng , Shufen Chu , Tingzheng Hou , Xiaoqin Zeng , Yujun Xie

View-based indexing schemes for 3D object retrieval are gaining popularity since they provide good retrieval results. These schemes are coherent with the theory that humans recognize objects based on their 2D appearances. The viewbased…

Computer Vision and Pattern Recognition · Computer Science 2011-05-16 Helin Dutagaci , Afzal Godil , Bulent Sankur , Yücel Yemez

For personalized medicines, very crucial intrinsic information is present in high dimensional omics data which is difficult to capture due to the large number of molecular features and small number of available samples. Different types of…

Machine Learning · Computer Science 2022-02-04 Sayed Hashim , Muhammad Ali , Karthik Nandakumar , Mohammad Yaqub

Virtual reality (VR) enables data visualization in an immersive and engaging manner, and it can be used for creating ways to explore scientific data. Here, we use VR for visualization of 3D histology data, creating a novel interface for…

Graphics · Computer Science 2022-01-31 Kaisa Liimatainen , Leena Latonen , Masi Valkonen , Kimmo Kartasalo , Pekka Ruusuvuori

3D reconstruction and view synthesis are foundational problems in computer vision, graphics, and immersive technologies such as augmented reality (AR), virtual reality (VR), and digital twins. Traditional methods rely on computationally…

Proteins are fundamental biological entities that play a key role in life activities. The amino acid sequences of proteins can be folded into stable 3D structures in the real physicochemical world, forming a special kind of…

Machine Learning · Computer Science 2023-01-04 Lirong Wu , Yufei Huang , Haitao Lin , Stan Z. Li

Rule-based modeling is a powerful way to model kinetic interactions in biochemical systems. Rules enable a precise encoding of biochemical interactions at the resolution of sites within molecules, but obtaining an integrated global view…

Quantitative Methods · Quantitative Biology 2015-09-04 John A. P. Sekar , Jose-Juan Tapia , James R. Faeder

Scientists studying deep ocean microbial ecosystems use limited numbers of sediment samples collected from the seafloor to characterize important life-sustaining biogeochemical cycles in the environment. Yet conducting fieldwork to sample…

While deep learning methods have achieved impressive success in many vision benchmarks, it remains difficult to understand and explain the representations and decisions of these models. Though vision models are typically trained on 2D…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Benjamin Beilharz , Thomas S. A. Wallis

Throughout our history, we, humans, have sought to better control and understand our environment. To this end, we have extended our natural senses with a host of sensors-tools that enable us to detect both the very large, such as the…

Biological Physics · Physics 2023-06-09 Kherim Willems

Bionic vision uses neuroprostheses to restore useful vision to people living with incurable blindness. However, a major outstanding challenge is predicting what people 'see' when they use their devices. The limited field of view of current…

Human-Computer Interaction · Computer Science 2022-03-14 Justin Kasowski , Michael Beyeler