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Numerous cellular functions rely on protein$\unicode{x2013}$protein interactions. Efforts to comprehensively characterize them remain challenged however by the diversity of molecular recognition mechanisms employed within the proteome. Deep…

Biomolecules · Quantitative Biology 2023-12-08 Julia R. Rogers , Gergő Nikolényi , Mohammed AlQuraishi

In this and the associated article 'BioBlender: A Software for Intuitive Representation of Surface Properties of Biomolecules', (Andrei et al) we present BioBlender as a complete instrument for the elaboration of motion (here) and the…

Biomolecules · Quantitative Biology 2010-09-27 Maria Francesca Zini , Yuri Porozov , Raluca Mihaela Andrei , Tiziana Loni , Claudia Caudai , Monica Zoppè

In the course of evolution, proteins undergo important changes in their amino acid sequences, while their three-dimensional folded structure and their biological function remain remarkably conserved. Thanks to modern sequencing techniques,…

Biomolecules · Quantitative Biology 2019-10-07 Simona Cocco , Christoph Feinauer , Matteo Figliuzzi , Remi Monasson , Martin Weigt

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Biomolecules · Quantitative Biology 2025-01-06 Weihang Dai

Artificial Intelligence & Nanotechnology are promising areas for the future of humanity. While Deep Learning based Computer Vision has found applications in many fields from medicine to automotive, its application in nanotechnology can open…

Computer Vision and Pattern Recognition · Computer Science 2022-01-05 Rajagopal A , Nirmala V , Andrew J , Arun Muthuraj Vedamanickam.

Protein sequence analysis underpins research in biophysics, computational biology, and bioinformatics. We introduce BEER, a crossplatform graphical interface that accepts FASTA or Protein Data Bank (PDB) files, or manual sequence entry, and…

Biomolecules · Quantitative Biology 2025-04-30 Saumyak Mukherjee

Understanding how monomeric proteins fold under in vitro conditions is crucial to describing their functions in the cellular context. Significant advances both in theory and experiments have resulted in a conceptual framework for describing…

Soft Condensed Matter · Physics 2010-07-20 D. Thirumalai , Edward P. O'Brien , Greg Morrison , Changbong Hyeon

In recent years, many mammographic image analysis methods have been introduced for improving cancer classification tasks. Two major issues of mammogram classification tasks are leveraging multi-view mammographic information and…

Computer Vision and Pattern Recognition · Computer Science 2023-09-08 Thanh-Huy Nguyen , Quang Hien Kha , Thai Ngoc Toan Truong , Ba Thinh Lam , Ba Hung Ngo , Quang Vinh Dinh , Nguyen Quoc Khanh Le

Proteins have evolved through mutations, amino acid substitutions, since life appeared on Earth, some 109 years ago. The study of these phenomena has been of particular significance because of their impact on protein stability, function,…

Biomolecules · Quantitative Biology 2023-10-25 Jorge A. Vila

Molecular representation learning aims to learn vector embeddings that capture molecular structure and geometry, thereby enabling property prediction and downstream scientific applications. In many AI for science tasks, labeled data are…

Biomolecules · Quantitative Biology 2026-01-28 Kun Li , Longtao Hu , Yida Xiong , Jiajun Yu , Hongzhi Zhang , Jiameng Chen , Xiantao Cai , Jia Wu , Wenbin Hu

Vision Transformers (ViTs) have emerged as the state-of-the-art architecture in representation learning, leveraging self-attention mechanisms to excel in various tasks. ViTs split images into fixed-size patches, constraining them to a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Aswathi Varma , Suprosanna Shit , Chinmay Prabhakar , Daniel Scholz , Hongwei Bran Li , Bjoern Menze , Daniel Rueckert , Benedikt Wiestler

Biomedical research increasingly relies on heterogeneous, high-dimensional datasets, yet effective visualization remains hindered by fragmented code resources, steep programming barriers, and limited domain-specific guidance. Bizard is an…

Self-supervised learning has emerged as a powerful paradigm for training deep neural networks, particularly in medical imaging where labeled data is scarce. While current approaches typically rely on synthetic augmentations of single…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Andre Dourson , Kylie Taylor , Xiaoli Qiao , Michael Fitzke

We present the results of a comprehensive analysis of visualization paper keywords supplied for 4366 papers submitted to five main visualization conferences. We describe main keywords, topic areas, and 10-year historic trends from two…

Digital Libraries · Computer Science 2024-04-25 Petra Isenberg , Tobias Isenberg , Michael Sedlmair , Jian Chen , Torsten Möller

Protein phosphorylation involves the reversible modification of a protein (substrate) residue by another protein (kinase). Liquid chromatography-mass spectrometry studies are rapidly generating massive protein phosphorylation datasets…

Protein-protein interactions are fundamental to many biological processes. Experimental screens have identified tens of thousands of interactions and structural biology has provided detailed functional insight for select 3D protein…

Accurate physical modeling with 3D-printing techniques could lead to new approaches to study structure and dynamics of biological systems complementing computational methods. Computational biology has become an important part of research…

Other Computer Science · Computer Science 2015-07-14 Promita Chakraborty

While stress visualization within 3-dimensional particles would greatly advance our understanding of the behaviors of complex particles, traditional photoelastic methods suffer from a lack of available technology for producing suitable…

Experimental approaches have been applied to address questions in understanding three-dimensional chromatin organisation and function. As datasets increase in size and complexity, it becomes a challenge to reach a mechanistic interpretation…

Biological Physics · Physics 2020-10-14 Chris A. Brackley , Davide Marenduzzo , Nick Gilbert

Accurate identification of protein nucleic-acid-binding residues poses a significant challenge with important implications for various biological processes and drug design. Many typical computational methods for protein analysis rely on a…

Biomolecules · Quantitative Biology 2023-12-21 Linglin Jing , Sheng Xu , Yifan Wang , Yuzhe Zhou , Tao Shen , Zhigang Ji , Hui Fang , Zhen Li , Siqi Sun
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